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M3K1_ARATH
ID   M3K1_ARATH              Reviewed;         608 AA.
AC   Q39008; O81470; Q39020; Q8W4N5;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   03-AUG-2022, entry version 152.
DE   RecName: Full=Mitogen-activated protein kinase kinase kinase 1;
DE            Short=ARAKIN;
DE            Short=AtMEKK1;
DE            Short=MAP kinase kinase kinase 1;
DE            EC=2.7.11.25 {ECO:0000269|PubMed:23857079};
GN   Name=MEKK1; OrderedLocusNames=At4g08500; ORFNames=T15F16.5;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC   STRAIN=cv. Columbia;
RX   PubMed=8570631; DOI=10.1073/pnas.93.2.765;
RA   Mizoguchi T., Irie K., Hirayama T., Hayashida N., Yamaguchi-Shinozaki K.,
RA   Matsumoto K., Shinozaki K.;
RT   "A gene encoding a mitogen-activated protein kinase kinase kinase is
RT   induced simultaneously with genes for a mitogen-activated protein kinase
RT   and an S6 ribosomal protein kinase by touch, cold, and water stress in
RT   Arabidopsis thaliana.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:765-769(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 115-608.
RX   PubMed=8597596; DOI=10.1016/0167-4781(95)00233-2;
RA   Covic L., Lew R.R.;
RT   "Arabidopsis thaliana cDNA isolated by functional complementation shows
RT   homology to serine/threonine protein kinases.";
RL   Biochim. Biophys. Acta 1305:125-129(1996).
RN   [6]
RP   INDUCTION.
RX   PubMed=10556579; DOI=10.1016/s0167-4889(99)00096-8;
RA   Covic L., Silva N.F., Lew R.R.;
RT   "Functional characterization of ARAKIN (ATMEKK1): a possible mediator in an
RT   osmotic stress response pathway in higher plants.";
RL   Biochim. Biophys. Acta 1451:242-254(1999).
RN   [7]
RP   SUBUNIT, AND INTERACTION WITH MKK1; MMK2 AND MPK4.
RX   PubMed=9878570; DOI=10.1006/bbrc.1998.9796;
RA   Ichimura K., Mizoguchi T., Irie K., Morris P.C., Giraudat J., Matsumoto K.,
RA   Shinozaki K.;
RT   "Isolation of ATMEKK1 (a MAP kinase kinase kinase)-interacting proteins and
RT   analysis of a MAP kinase cascade in Arabidopsis.";
RL   Biochem. Biophys. Res. Commun. 253:532-543(1998).
RN   [8]
RP   FUNCTION.
RX   PubMed=11875555; DOI=10.1038/415977a;
RA   Asai T., Tena G., Plotnikova J., Willmann M.R., Chiu W.-L., Gomez-Gomez L.,
RA   Boller T., Ausubel F.M., Sheen J.;
RT   "MAP kinase signalling cascade in Arabidopsis innate immunity.";
RL   Nature 415:977-983(2002).
RN   [9]
RP   NOMENCLATURE.
RX   PubMed=12119167; DOI=10.1016/s1360-1385(02)02302-6;
RG   MAPK group;
RT   "Mitogen-activated protein kinase cascades in plants: a new nomenclature.";
RL   Trends Plant Sci. 7:301-308(2002).
RN   [10]
RP   FUNCTION.
RX   PubMed=15225555; DOI=10.1016/j.molcel.2004.06.023;
RA   Teige M., Scheikl E., Eulgem T., Doczi R., Ichimura K., Shinozaki K.,
RA   Dangl J.L., Hirt H.;
RT   "The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis.";
RL   Mol. Cell 15:141-152(2004).
RN   [11]
RP   FUNCTION, AND INTERACTION WITH MKK1; MKK2 AND MPK4.
RX   PubMed=18982020; DOI=10.1038/cr.2008.300;
RA   Gao M., Liu J., Bi D., Zhang Z., Cheng F., Chen S., Zhang Y.;
RT   "MEKK1, MKK1/MKK2 and MPK4 function together in a mitogen-activated protein
RT   kinase cascade to regulate innate immunity in plants.";
RL   Cell Res. 18:1190-1198(2008).
RN   [12]
RP   INTERACTION WITH CRLK1, AND SUBCELLULAR LOCATION.
RX   PubMed=20724845; DOI=10.4161/psb.5.8.12225;
RA   Yang T., Shad Ali G., Yang L., Du L., Reddy A.S., Poovaiah B.W.;
RT   "Calcium/calmodulin-regulated receptor-like kinase CRLK1 interacts with
RT   MEKK1 in plants.";
RL   Plant Signal. Behav. 5:991-994(2010).
RN   [13]
RP   CATALYTIC ACTIVITY, ACTIVITY REGULATION, AND PHOSPHORYLATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=23857079; DOI=10.1007/s10265-013-0576-0;
RA   Furuya T., Matsuoka D., Nanmori T.;
RT   "Phosphorylation of Arabidopsis thaliana MEKK1 via Ca(2+) signaling as a
RT   part of the cold stress response.";
RL   J. Plant Res. 126:833-840(2013).
RN   [14]
RP   INTERACTION WITH RACK1A; RACK1B AND RACK1C.
RX   PubMed=25731164; DOI=10.1038/nature14243;
RA   Cheng Z., Li J.F., Niu Y., Zhang X.C., Woody O.Z., Xiong Y., Djonovic S.,
RA   Millet Y., Bush J., McConkey B.J., Sheen J., Ausubel F.M.;
RT   "Pathogen-secreted proteases activate a novel plant immune pathway.";
RL   Nature 521:213-216(2015).
CC   -!- FUNCTION: The MEKK1, MKK1/MKK2 and MPK4 function in a signaling pathway
CC       that modulates the expression of genes responding to biotic and abiotic
CC       stresses and also plays an important role in pathogen defense by
CC       negatively regulating innate immunity. Involved in the innate immune
CC       MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6)
CC       downstream of bacterial flagellin receptor FLS2. May be involved in the
CC       cold and salinity stress-mediated MAP kinase signaling cascade (MEKK1,
CC       MKK1/MKK2 and MPK4/MPK6). Activates by phosphorylation the downstream
CC       MKK2, MKK4 and MKK5 in a calcium-dependent manner.
CC       {ECO:0000269|PubMed:11875555, ECO:0000269|PubMed:15225555,
CC       ECO:0000269|PubMed:18982020, ECO:0000269|PubMed:23857079}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25;
CC         Evidence={ECO:0000269|PubMed:23857079};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.25; Evidence={ECO:0000269|PubMed:23857079};
CC   -!- ACTIVITY REGULATION: Activated by cold via CRLK1-mediated
CC       phosphorylation and leading to elevated kinase activity towards MKK2.
CC       {ECO:0000269|PubMed:23857079}.
CC   -!- SUBUNIT: Interacts with MKK1, MMK2 and MPK4. May form a ternary complex
CC       composed of MEKK1 and MKK1/MKK2 and MPK4 (PubMed:18982020,
CC       PubMed:9878570). Interacts with RACK1A, RACK1B and RACK1C
CC       (PubMed:25731164). Binds to CRLK1 (PubMed:20724845).
CC       {ECO:0000269|PubMed:18982020, ECO:0000269|PubMed:20724845,
CC       ECO:0000269|PubMed:25731164, ECO:0000269|PubMed:9878570}.
CC   -!- INTERACTION:
CC       Q39008; Q94A06: MKK1; NbExp=4; IntAct=EBI-994439, EBI-994464;
CC       Q39008; Q9SUP6: WRKY53; NbExp=5; IntAct=EBI-994439, EBI-1235980;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20724845}.
CC       Endosome {ECO:0000269|PubMed:20724845}.
CC   -!- INDUCTION: By touch, cold and salinity stress.
CC       {ECO:0000269|PubMed:10556579, ECO:0000269|PubMed:8570631}.
CC   -!- PTM: Phosphorylated by CRLK1 in response to cold.
CC       {ECO:0000269|PubMed:23857079}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase kinase subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA99196.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAA99196.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR   EMBL; D50468; BAA09057.1; -; mRNA.
DR   EMBL; AF076275; AAC28196.1; -; Genomic_DNA.
DR   EMBL; AL161511; CAB77975.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE82651.1; -; Genomic_DNA.
DR   EMBL; AY062459; AAL32537.1; -; mRNA.
DR   EMBL; BT000116; AAN15435.1; -; mRNA.
DR   EMBL; L43125; AAA99196.1; ALT_SEQ; Genomic_DNA.
DR   PIR; T01833; T01833.
DR   RefSeq; NP_192590.1; NM_116919.4.
DR   AlphaFoldDB; Q39008; -.
DR   SMR; Q39008; -.
DR   BioGRID; 11709; 9.
DR   IntAct; Q39008; 3.
DR   STRING; 3702.AT4G08500.1; -.
DR   iPTMnet; Q39008; -.
DR   PaxDb; Q39008; -.
DR   PRIDE; Q39008; -.
DR   ProteomicsDB; 238790; -.
DR   EnsemblPlants; AT4G08500.1; AT4G08500.1; AT4G08500.
DR   GeneID; 826409; -.
DR   Gramene; AT4G08500.1; AT4G08500.1; AT4G08500.
DR   KEGG; ath:AT4G08500; -.
DR   Araport; AT4G08500; -.
DR   TAIR; locus:2133559; AT4G08500.
DR   eggNOG; KOG0198; Eukaryota.
DR   HOGENOM; CLU_000288_2_6_1; -.
DR   InParanoid; Q39008; -.
DR   OMA; HIDYEAA; -.
DR   OrthoDB; 630495at2759; -.
DR   PhylomeDB; Q39008; -.
DR   BRENDA; 2.7.11.25; 399.
DR   PRO; PR:Q39008; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q39008; baseline and differential.
DR   Genevisible; Q39008; AT.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005768; C:endosome; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR   GO; GO:0019900; F:kinase binding; IPI:TAIR.
DR   GO; GO:0004709; F:MAP kinase kinase kinase activity; IDA:UniProtKB.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
DR   GO; GO:0009631; P:cold acclimation; IDA:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0000165; P:MAPK cascade; IMP:TAIR.
DR   GO; GO:0046777; P:protein autophosphorylation; HDA:TAIR.
DR   GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0009409; P:response to cold; IDA:UniProtKB.
DR   GO; GO:1902065; P:response to L-glutamate; IMP:TAIR.
DR   GO; GO:0006970; P:response to osmotic stress; IEP:TAIR.
DR   GO; GO:0009651; P:response to salt stress; IEP:TAIR.
DR   GO; GO:0009611; P:response to wounding; IDA:TAIR.
DR   GO; GO:0010449; P:root meristem growth; IGI:TAIR.
DR   GO; GO:0022622; P:root system development; IMP:TAIR.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cell membrane; Endosome; Immunity; Innate immunity; Kinase;
KW   Membrane; Nucleotide-binding; Phosphoprotein; Plant defense;
KW   Reference proteome; Serine/threonine-protein kinase; Stress response;
KW   Transferase.
FT   CHAIN           1..608
FT                   /note="Mitogen-activated protein kinase kinase kinase 1"
FT                   /id="PRO_0000245826"
FT   DOMAIN          333..587
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          1..325
FT                   /note="Regulatory region"
FT                   /evidence="ECO:0000269|PubMed:9878570"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          192..234
FT                   /note="Binding with MPK4"
FT                   /evidence="ECO:0000269|PubMed:9878570"
FT   REGION          228..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        456
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10027"
FT   BINDING         339..347
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         361
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   MOD_RES         62
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O81472"
FT   MOD_RES         603
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O81472"
FT   CONFLICT        39
FT                   /note="D -> A (in Ref. 1; AAC28196)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        341
FT                   /note="R -> L (in Ref. 4; AAL32537/AAN15435)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   608 AA;  66024 MW;  70C1A1C314E2DFDD CRC64;
     MDRILARMKK STGRRGGDKN ITPVRRLERR DAARNINYDA ASCSSSSAED LSVSTSSLMT
     RSLEFPEPTS FRIGGGVGEM DRIYRSLGVS GPDDLAISFD AWEACKKRSS SDVVNRFKSF
     DLDKVRDQDL SEEGPSGVVV GSDSMNHKVQ GQDLSEAGPS GGIVTELSEI GNLITPVDRL
     VADGVVENRR VMERTPTIVK SKGYLVPNNV VAVGVGVGGG IKGLRPPVLK PPPAMKRPPI
     DHRGSSWDFL THFAPSETVK RPSSSSSSSE DGCDEEEGKE EEAEAEEMGA RFIQLGDTAD
     ETCSFTTNEG DSSSTVSNTS PIYPDGGAII TSWQKGQLLG RGSFGSVYEG ISGDGDFFAV
     KEVSLLDQGS QAQECIQQLE GEIKLLSQLQ HQNIVRYRGT AKDGSNLYIF LELVTQGSLL
     KLYQRYQLRD SVVSLYTRQI LDGLKYLHDK GFIHRDIKCA NILVDANGAV KLADFGLAKV
     SKFNDIKSCK GTPFWMAPEV INRKDSDGYG SPADIWSLGC TVLEMCTGQI PYSDLEPVQA
     LFRIGRGTLP EVPDTLSLDA RLFILKCLKV NPEERPTAAE LLNHPFVRRP LPSVGSGGSG
     SASPLLRR
 
 
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