M3KCL_HUMAN
ID M3KCL_HUMAN Reviewed; 142 AA.
AC P57077; D3DSE0; Q8TCL9;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 07-OCT-2020, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=MAP3K7 C-terminal-like protein;
DE AltName: Full=TAK1-like protein;
GN Name=MAP3K7CL; Synonyms=C21orf7, TAK1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2).
RA Solans A., Domenech A., Estivill X., de la Luna S.;
RT "Cloning and characterization of a new gene, C21orf7, similar to the TAB2-
RT binding region of TAK1.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1).
RX PubMed=11707072; DOI=10.1006/geno.2001.6640;
RA Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S.,
RA Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.;
RT "From PREDs and open reading frames to cDNA isolation: revisiting the human
RT chromosome 21 transcription map.";
RL Genomics 78:46-54(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=15168726; DOI=10.1023/b:bigi.0000020468.96238.54;
RA Li J., Ji C., Yang Q., Chen J., Gu S., Ying K., Xie Y., Mao Y.;
RT "Cloning and characterization of a novel human TGF-beta activated kinase-
RT like gene.";
RL Biochem. Genet. 42:129-137(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
RX PubMed=14759258; DOI=10.1186/gb-2004-5-2-r8;
RA Hillman R.T., Green R.E., Brenner S.E.;
RT "An unappreciated role for RNA surveillance.";
RL Genome Biol. 5:R8.1-R8.16(2004).
CC -!- INTERACTION:
CC P57077; Q13227: GPS2; NbExp=2; IntAct=EBI-748831, EBI-713355;
CC P57077-4; Q96MA6: AK8; NbExp=6; IntAct=EBI-10215880, EBI-8466265;
CC P57077-4; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-10215880, EBI-742054;
CC P57077-4; Q15323: KRT31; NbExp=3; IntAct=EBI-10215880, EBI-948001;
CC P57077-4; O76011: KRT34; NbExp=3; IntAct=EBI-10215880, EBI-1047093;
CC P57077-4; Q04864: REL; NbExp=3; IntAct=EBI-10215880, EBI-307352;
CC P57077-4; Q8N5C8: TAB3; NbExp=6; IntAct=EBI-10215880, EBI-359964;
CC P57077-4; P22415: USF1; NbExp=3; IntAct=EBI-10215880, EBI-1054489;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=D {ECO:0000303|Ref.1};
CC IsoId=P57077-4; Sequence=Displayed;
CC Name=2; Synonyms=A {ECO:0000303|Ref.1};
CC IsoId=P57077-1; Sequence=VSP_060759;
CC -!- TISSUE SPECIFICITY: Detected in lung and peripheral blood leukocytes.
CC Expressed predominantly in peripheral blood leukocytes and ubiquitously
CC in adult and fetal tissues. Also expressed strongly in breast carcinoma
CC GI-101, colon adenocarcinoma GI-112, and prostatic adenocarcinoma PC3.
CC {ECO:0000269|PubMed:15168726}.
CC -!- DOMAIN: Contains a C-terminal domain similar to that of the C-terminal
CC section of MAP3K7.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF81752.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=AAF81753.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=CAB90434.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF269161; AAF81751.1; -; mRNA.
DR EMBL; AF269162; AAF81752.1; ALT_SEQ; mRNA.
DR EMBL; AF269163; AAF81753.1; ALT_SEQ; mRNA.
DR EMBL; AF269164; AAF81754.1; -; mRNA.
DR EMBL; AY033900; AAK68718.1; -; mRNA.
DR EMBL; AY171599; AAO16519.1; -; mRNA.
DR EMBL; AL713701; CAD28500.1; -; mRNA.
DR EMBL; AL163249; CAB90434.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471079; EAX09921.1; -; Genomic_DNA.
DR EMBL; CH471079; EAX09923.1; -; Genomic_DNA.
DR EMBL; BC008567; AAH08567.1; -; mRNA.
DR CCDS; CCDS13584.1; -. [P57077-1]
DR CCDS; CCDS68182.1; -. [P57077-4]
DR RefSeq; NP_001273546.1; NM_001286617.1. [P57077-4]
DR RefSeq; NP_001273547.1; NM_001286618.1. [P57077-4]
DR RefSeq; NP_001273548.1; NM_001286619.1. [P57077-4]
DR RefSeq; NP_001273549.1; NM_001286620.1. [P57077-4]
DR RefSeq; NP_001273551.1; NM_001286622.1.
DR RefSeq; NP_001273553.1; NM_001286624.1.
DR RefSeq; NP_001273563.1; NM_001286634.1. [P57077-1]
DR RefSeq; NP_064537.1; NM_020152.3. [P57077-1]
DR AlphaFoldDB; P57077; -.
DR SMR; P57077; -.
DR BioGRID; 121239; 10.
DR IntAct; P57077; 9.
DR STRING; 9606.ENSP00000382828; -.
DR BioMuta; MAP3K7CL; -.
DR DMDM; 10719918; -.
DR MassIVE; P57077; -.
DR MaxQB; P57077; -.
DR PaxDb; P57077; -.
DR PeptideAtlas; P57077; -.
DR PRIDE; P57077; -.
DR Antibodypedia; 6479; 154 antibodies from 19 providers.
DR DNASU; 56911; -.
DR Ensembl; ENST00000286791.9; ENSP00000286791.6; ENSG00000156265.16. [P57077-1]
DR Ensembl; ENST00000339024.8; ENSP00000345777.4; ENSG00000156265.16. [P57077-4]
DR Ensembl; ENST00000341618.8; ENSP00000343212.4; ENSG00000156265.16. [P57077-1]
DR Ensembl; ENST00000399925.5; ENSP00000382809.1; ENSG00000156265.16. [P57077-4]
DR Ensembl; ENST00000399926.5; ENSP00000382810.1; ENSG00000156265.16. [P57077-4]
DR Ensembl; ENST00000399928.6; ENSP00000382812.1; ENSG00000156265.16. [P57077-4]
DR Ensembl; ENST00000399934.5; ENSP00000382816.1; ENSG00000156265.16. [P57077-4]
DR Ensembl; ENST00000399935.6; ENSP00000382817.2; ENSG00000156265.16. [P57077-4]
DR Ensembl; ENST00000399947.6; ENSP00000382828.2; ENSG00000156265.16. [P57077-1]
DR GeneID; 56911; -.
DR KEGG; hsa:56911; -.
DR MANE-Select; ENST00000399928.6; ENSP00000382812.1; NM_001286620.2; NP_001273549.1.
DR UCSC; uc002ynd.5; human. [P57077-4]
DR CTD; 56911; -.
DR DisGeNET; 56911; -.
DR GeneCards; MAP3K7CL; -.
DR HGNC; HGNC:16457; MAP3K7CL.
DR HPA; ENSG00000156265; Tissue enhanced (skeletal muscle, tongue).
DR MIM; 611110; gene.
DR neXtProt; NX_P57077; -.
DR OpenTargets; ENSG00000156265; -.
DR PharmGKB; PA25864; -.
DR VEuPathDB; HostDB:ENSG00000156265; -.
DR eggNOG; ENOG502S2UX; Eukaryota.
DR GeneTree; ENSGT00770000120675; -.
DR HOGENOM; CLU_100451_0_0_1; -.
DR InParanoid; P57077; -.
DR OMA; MAQSQCV; -.
DR PhylomeDB; P57077; -.
DR TreeFam; TF335499; -.
DR PathwayCommons; P57077; -.
DR SignaLink; P57077; -.
DR BioGRID-ORCS; 56911; 20 hits in 1064 CRISPR screens.
DR ChiTaRS; MAP3K7CL; human.
DR GeneWiki; C21orf7; -.
DR GenomeRNAi; 56911; -.
DR Pharos; P57077; Tdark.
DR PRO; PR:P57077; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P57077; protein.
DR Bgee; ENSG00000156265; Expressed in monocyte and 125 other tissues.
DR ExpressionAtlas; P57077; baseline and differential.
DR Genevisible; P57077; HS.
DR GO; GO:0005829; C:cytosol; HDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR InterPro; IPR042800; Map3k7cl.
DR PANTHER; PTHR47140; PTHR47140; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..142
FT /note="MAP3K7 C-terminal-like protein"
FT /id="PRO_0000072423"
FT VAR_SEQ 1..23
FT /note="MISTARVPADKPVRIAFSLNDAS -> MVQLIAPLEVMWNEAADLKPLALSR
FT RLECSGGIMAHYSPDLLGPEMESRYFAQVGLEHLASSSPPAFGFLKCLDYSISVLCSAT
FT SLAMLEDNPKVSKLATGDWMLTLKPKSITVPVEIPSSPL (in isoform 2)"
FT /id="VSP_060759"
FT CONFLICT 60
FT /note="K -> R (in Ref. 4; CAD28500)"
FT /evidence="ECO:0000305"
FT CONFLICT 70
FT /note="H -> L (in Ref. 4; CAD28500)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="K -> E (in Ref. 4; CAD28500)"
FT /evidence="ECO:0000305"
FT VARIANT P57077-1:112
FT /note="I -> V (in dbSNP:rs3746843)"
FT /id="VAR_083830"
SQ SEQUENCE 142 AA; 16372 MW; 7F9BCBAF69F25444 CRC64;
MISTARVPAD KPVRIAFSLN DASDDTPPED SIPLVFPELD QQLQPLPPCH DSEESMEVFK
QHCQIAEEYH EVKKEITLLE QRKKELIAKL DQAEKEKVDA AELVREFEAL TEENRTLRLA
QSQCVEQLEK LRIQYQKRQG SS
