ID   M3L_DICDI               Reviewed;         511 AA.
AC   P18154; Q55AQ5; Q75JB1;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=cAMP-regulated M3L protein;
DE   AltName: Full=Proteasomal alpha-subunit M3;
GN   Name=prtA; Synonyms=M3L; ORFNames=DDB_G0271696;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-256.
RC   STRAIN=NC-4;
RX   PubMed=3031475; DOI=10.1128/mcb.7.1.458-469.1987;
RA   Mann S.K.O., Firtel R.A.;
RT   "Cyclic AMP regulation of early gene expression in Dictyostelium
RT   discoideum: mediation via the cell surface cyclic AMP receptor.";
RL   Mol. Cell. Biol. 7:458-469(1987).
CC   -!- INDUCTION: Stimulation by changing levels of cAMP via the cell surface
CC       cAMP receptor.
CC   -!- SIMILARITY: To D.discoideum protein M3R. {ECO:0000305}.
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DR   EMBL; AAFI02000006; EAL71538.1; -; Genomic_DNA.
DR   EMBL; M15967; AAA33220.1; -; Genomic_DNA.
DR   PIR; B26720; B26720.
DR   RefSeq; XP_645467.1; XM_640375.1.
DR   AlphaFoldDB; P18154; -.
DR   SMR; P18154; -.
DR   PaxDb; P18154; -.
DR   PRIDE; P18154; -.
DR   EnsemblProtists; EAL71538; EAL71538; DDB_G0271696.
DR   GeneID; 8618095; -.
DR   KEGG; ddi:DDB_G0271696; -.
DR   dictyBase; DDB_G0271696; prtA.
DR   HOGENOM; CLU_531497_0_0_1; -.
DR   PhylomeDB; P18154; -.
DR   PRO; PR:P18154; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0090729; F:toxin activity; IEA:InterPro.
DR   Gene3D; 1.20.190.10; -; 1.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   cAMP; Reference proteome.
FT   CHAIN           1..511
FT                   /note="cAMP-regulated M3L protein"
FT                   /id="PRO_0000084540"
FT   CONFLICT        88
FT                   /note="Y -> N (in Ref. 3; AAA33220)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        97
FT                   /note="G -> W (in Ref. 3; AAA33220)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        124
FT                   /note="A -> T (in Ref. 3; AAA33220)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        128
FT                   /note="K -> Q (in Ref. 3; AAA33220)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        138
FT                   /note="F -> Y (in Ref. 3; AAA33220)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        185
FT                   /note="T -> S (in Ref. 3; AAA33220)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   511 AA;  58410 MW;  9FA13320BC156945 CRC64;
     MESLKNNDER IENFLNELKN LQSNIDKDIK EFSNSPNTSN AEKDGKFLSK HDEELYNKQI
     IRLTQEDRIS NLSSLINSNI EDSFLLAYQT ILNNLPGVGP VFQMIFGIMG NGIDLEKFYK
     EIIAQVEKMI KKSLEDYFKN QCNIIFNNLG KACDQHKELT QKWYDNHGIR SMNHLGEEIP
     QSSSTIESDE TLTPMIHASY LDLKMKFNDA LTYFTDSKYR GHVAPLLTYT SVMYFAFLRD
     ILKYGKEMKF DNSIIDGTAN TPGIKKISND FVNKSLSEFL KSGVEYTKVV NSLQEGEWQT
     YPPPIGRVWV PPVPIEWVSP PATSLALKFF LANTDNYPKG GKVVKVTNGY YELSPIKMTY
     ALEVYYSSGH GYSVNYYPSY RFGGKPILPL IAPVVNTLFT MLNPNRFSRT FKIRITHKIV
     REAKWNLDFF DNEVGEAGSF NQKFVFTSTT SHINPICDKS ETAGVTEIPG PFTTDKKYIR
     LTCIRKFNLQ EPKNEGYAYG SSIFSVELID L