ID   M3R_DICDI               Reviewed;         513 AA.
AC   P11872; Q55AQ6; Q75JB2;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 4.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=cAMP-regulated M3R protein;
DE   AltName: Full=Proteasomal alpha-subunit 7-1;
GN   Name=prtB; Synonyms=M3R; ORFNames=DDB_G0271666;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-257.
RC   STRAIN=NC-4;
RX   PubMed=3031475; DOI=10.1128/mcb.7.1.458-469.1987;
RA   Mann S.K.O., Firtel R.A.;
RT   "Cyclic AMP regulation of early gene expression in Dictyostelium
RT   discoideum: mediation via the cell surface cyclic AMP receptor.";
RL   Mol. Cell. Biol. 7:458-469(1987).
CC   -!- INDUCTION: Stimulation by changing levels of cAMP via the cell surface
CC       cAMP receptor.
CC   -!- SIMILARITY: To D.discoideum protein M3L. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000006; EAL71523.2; -; Genomic_DNA.
DR   EMBL; M15968; AAA33221.1; -; Genomic_DNA.
DR   PIR; A26720; A26720.
DR   RefSeq; XP_645466.2; XM_640374.2.
DR   AlphaFoldDB; P11872; -.
DR   STRING; 44689.DDB0185115; -.
DR   PaxDb; P11872; -.
DR   EnsemblProtists; EAL71523; EAL71523; DDB_G0271666.
DR   GeneID; 8618094; -.
DR   KEGG; ddi:DDB_G0271666; -.
DR   dictyBase; DDB_G0271666; prtB.
DR   HOGENOM; CLU_531497_0_0_1; -.
DR   PhylomeDB; P11872; -.
DR   PRO; PR:P11872; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0090729; F:toxin activity; IEA:InterPro.
DR   Gene3D; 1.20.190.10; -; 1.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   cAMP; Reference proteome.
FT   CHAIN           1..513
FT                   /note="cAMP-regulated M3R protein"
FT                   /id="PRO_0000084541"
FT   CONFLICT        124
FT                   /note="T -> A (in Ref. 3; AAA33221)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        128
FT                   /note="Q -> K (in Ref. 3; AAA33221)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        138
FT                   /note="Y -> F (in Ref. 3; AAA33221)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        156
FT                   /note="H -> Q (in Ref. 3; AAA33221)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        177
FT                   /note="K -> E (in Ref. 3; AAA33221)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        184
FT                   /note="Missing (in Ref. 3; AAA33221)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        256
FT                   /note="L -> T (in Ref. 3; AAA33221)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   513 AA;  58133 MW;  9415BEF264EE8BC6 CRC64;
     MESLKNNGEK IENFLNQLKN LQSNVDKDFK EFSNSPNTLN AEKDGEFLDK HDEELYNKQI
     IRSRLEDKIS NLSSSMINDI GNDFQTGFQT ILYNLPGVGP VFQMIFNIMG NGINLEKFYQ
     EIITQVEQMI KKSLEDYYKN QCNTIFKNLG KACDQHKDLT QKWYDKNGIK SMNHLGKEIP
     QSTSSTIESD DTLTPMIHAS YLDLKIKFND AITSFTDAKY RGHVAPLLTY TSVMYVAFLR
     DILKYGKEMK FDDSVLNGSA NTPGIKKMLN DFVNVTLSEF LISGREYTNV VNSLQEGYWI
     TYPPPIYKVW VPPQQASWVS PPASELAHKF FLAHSDNYPQ GGDLIYIKKD GVYELSPNKI
     THALEVYYSS GGGYGVNDYP SFRYGGKPII PLLAPVGNAV FTMLNPNRYK RTFKIRIVHV
     IVREAKWNLD CYDNQVGEAG SFNQNFVFTS TNIVSDPICG NIGTVGITEI PGPFTTDKKY
     IRLTCIRKVN FPASKNEGYA VGSRILSVQL IDL