M4A10_HUMAN
ID M4A10_HUMAN Reviewed; 267 AA.
AC Q96PG2; B2RP45; Q96PG3;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Membrane-spanning 4-domains subfamily A member 10;
DE AltName: Full=CD20 antigen-like 7;
GN Name=MS4A10; Synonyms=CD20L7, MS4A9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-61 AND 202-241.
RX PubMed=11486273; DOI=10.1007/s002510100339;
RA Liang Y., Buckley T.R., Tu L., Langdon S.D., Tedder T.F.;
RT "Structural organization of the human MS4A gene cluster on chromosome
RT 11q12.";
RL Immunogenetics 53:357-368(2001).
CC -!- FUNCTION: May be involved in signal transduction as a component of a
CC multimeric receptor complex.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR EMBL; AK122633; BAC85498.1; -; mRNA.
DR EMBL; AP004243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137259; AAI37260.1; -; mRNA.
DR EMBL; BC137263; AAI37264.1; -; mRNA.
DR EMBL; AF354934; AAL07361.1; -; Genomic_DNA.
DR EMBL; AF354935; AAL07362.1; -; Genomic_DNA.
DR CCDS; CCDS7992.1; -.
DR RefSeq; NP_996776.2; NM_206893.3.
DR AlphaFoldDB; Q96PG2; -.
DR SMR; Q96PG2; -.
DR BioGRID; 131117; 8.
DR IntAct; Q96PG2; 2.
DR STRING; 9606.ENSP00000311862; -.
DR TCDB; 1.A.37.2.1; the cd20 ca(2+) channel (cd20) family.
DR iPTMnet; Q96PG2; -.
DR PhosphoSitePlus; Q96PG2; -.
DR BioMuta; MS4A10; -.
DR DMDM; 296439309; -.
DR MassIVE; Q96PG2; -.
DR PaxDb; Q96PG2; -.
DR PeptideAtlas; Q96PG2; -.
DR PRIDE; Q96PG2; -.
DR ProteomicsDB; 77691; -.
DR TopDownProteomics; Q96PG2; -.
DR Antibodypedia; 70877; 5 antibodies from 5 providers.
DR DNASU; 341116; -.
DR Ensembl; ENST00000308287.2; ENSP00000311862.1; ENSG00000172689.2.
DR GeneID; 341116; -.
DR KEGG; hsa:341116; -.
DR MANE-Select; ENST00000308287.2; ENSP00000311862.1; NM_206893.4; NP_996776.2.
DR UCSC; uc001npz.1; human.
DR CTD; 341116; -.
DR GeneCards; MS4A10; -.
DR HGNC; HGNC:13368; MS4A10.
DR HPA; ENSG00000172689; Tissue enriched (intestine).
DR MIM; 608403; gene.
DR neXtProt; NX_Q96PG2; -.
DR OpenTargets; ENSG00000172689; -.
DR PharmGKB; PA31110; -.
DR VEuPathDB; HostDB:ENSG00000172689; -.
DR eggNOG; ENOG502SH2M; Eukaryota.
DR GeneTree; ENSGT00390000010921; -.
DR HOGENOM; CLU_1041911_0_0_1; -.
DR InParanoid; Q96PG2; -.
DR OMA; PFESPIW; -.
DR OrthoDB; 1363106at2759; -.
DR PhylomeDB; Q96PG2; -.
DR TreeFam; TF339722; -.
DR PathwayCommons; Q96PG2; -.
DR BioGRID-ORCS; 341116; 11 hits in 1060 CRISPR screens.
DR GenomeRNAi; 341116; -.
DR Pharos; Q96PG2; Tdark.
DR PRO; PR:Q96PG2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96PG2; protein.
DR Bgee; ENSG00000172689; Expressed in duodenum and 13 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR030417; MS4A.
DR PANTHER; PTHR23320; PTHR23320; 1.
DR Pfam; PF04103; CD20; 1.
PE 2: Evidence at transcript level;
KW Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..267
FT /note="Membrane-spanning 4-domains subfamily A member 10"
FT /id="PRO_0000158646"
FT TOPO_DOM 1..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..91
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..171
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..267
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 219
FT /note="P -> L (in dbSNP:rs12419635)"
FT /id="VAR_057652"
FT CONFLICT 48
FT /note="E -> D (in Ref. 1; BAC85498)"
FT /evidence="ECO:0000305"
FT CONFLICT 263
FT /note="T -> A (in Ref. 1; BAC85498)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 267 AA; 29747 MW; 39FC0395825B2E78 CRC64;
MKAEATVIPS RCARGLPSWQ VLSPVQPWQT SAPQNTTQPK LLAPHQHEKS QKKSSLLKEL
GAFHITIALL HLVFGGYLAS IVKNLHLVVL KSWYPFWGAA SFLISGILAI TMKTFSKTYL
KMLCLMTNLI SLFCVLSGLF VISKDLFLES PFESPIWRMY PNSTVHIQRL ELALLCFTVL
ELFLPVPTAV TAWRGDCPSA KNDDACLVPN TPLHLKGLPV EPPPSYQSVI QGDAQHKQHQ
RLREVKQVAP DTWIVTDGAA IWTQTAN
