M4A10_MOUSE
ID M4A10_MOUSE Reviewed; 267 AA.
AC Q99N03; Q9D8H8; Q9EQY8;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Membrane-spanning 4-domains subfamily A member 10;
GN Name=Ms4a10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Fetus;
RX PubMed=11401424; DOI=10.1006/geno.2000.6472;
RA Liang Y., Tedder T.F.;
RT "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene
RT family: sixteen new MS4A family members expressed in human and mouse.";
RL Genomics 72:119-127(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=11245982; DOI=10.1016/s0378-1119(00)00598-9;
RA Ishibashi K., Suzuki M., Sasaki S., Imai M.;
RT "Identification of a new multigene four-transmembrane family (MS4A) related
RT to CD20, HTm4 and beta subunit of the high-affinity IgE receptor.";
RL Gene 264:87-93(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be involved in signal transduction as a component of a
CC multimeric receptor complex.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q99N03-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q99N03-2; Sequence=VSP_007387;
CC -!- TISSUE SPECIFICITY: Expressed in thymus, kidney, colon, brain and
CC testis. Expressed also by various hematopoietic and lymphoblastoid cell
CC lines.
CC -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB18758.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF237918; AAK37614.1; -; mRNA.
DR EMBL; AB026046; BAB18758.1; ALT_FRAME; mRNA.
DR EMBL; AK008019; BAB25413.1; -; mRNA.
DR CCDS; CCDS37919.1; -. [Q99N03-1]
DR RefSeq; NP_076018.2; NM_023529.2. [Q99N03-1]
DR RefSeq; XP_006527392.1; XM_006527329.2. [Q99N03-2]
DR AlphaFoldDB; Q99N03; -.
DR IntAct; Q99N03; 1.
DR MINT; Q99N03; -.
DR STRING; 10090.ENSMUSP00000072531; -.
DR PhosphoSitePlus; Q99N03; -.
DR PaxDb; Q99N03; -.
DR PRIDE; Q99N03; -.
DR ProteomicsDB; 292069; -. [Q99N03-1]
DR ProteomicsDB; 292070; -. [Q99N03-2]
DR Antibodypedia; 70877; 5 antibodies from 5 providers.
DR DNASU; 69826; -.
DR Ensembl; ENSMUST00000072748; ENSMUSP00000072531; ENSMUSG00000024731. [Q99N03-1]
DR Ensembl; ENSMUST00000191343; ENSMUSP00000140111; ENSMUSG00000024731. [Q99N03-2]
DR GeneID; 69826; -.
DR KEGG; mmu:69826; -.
DR UCSC; uc008grk.1; mouse. [Q99N03-1]
DR UCSC; uc012bir.1; mouse. [Q99N03-2]
DR CTD; 341116; -.
DR MGI; MGI:1917076; Ms4a10.
DR VEuPathDB; HostDB:ENSMUSG00000024731; -.
DR eggNOG; ENOG502SH2M; Eukaryota.
DR GeneTree; ENSGT00390000010921; -.
DR HOGENOM; CLU_1041911_0_0_1; -.
DR InParanoid; Q99N03; -.
DR OMA; PFESPIW; -.
DR PhylomeDB; Q99N03; -.
DR TreeFam; TF339722; -.
DR BioGRID-ORCS; 69826; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q99N03; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q99N03; protein.
DR Bgee; ENSMUSG00000024731; Expressed in small intestine Peyer's patch and 29 other tissues.
DR ExpressionAtlas; Q99N03; baseline and differential.
DR Genevisible; Q99N03; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR030417; MS4A.
DR PANTHER; PTHR23320; PTHR23320; 1.
DR Pfam; PF04103; CD20; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Receptor; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..267
FT /note="Membrane-spanning 4-domains subfamily A member 10"
FT /id="PRO_0000158647"
FT TOPO_DOM 1..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..83
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..118
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..267
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 59..98
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_007387"
FT CONFLICT 97
FT /note="V -> G (in Ref. 2; BAB18758)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 267 AA; 28972 MW; ACDBB12FD2053BC4 CRC64;
MAGQAPTAVP GSVTGEVSRW QNLGPAQPAQ KVAQPQNLVP DGHLEKALEG SDLLQKLGGF
HIAIAFAHLA FGGYLISTVK NLHLVVLKCW YPLWGTVSFL VAGMAAMTTV TFPKTSLKVL
CVIANVISLF CALAGFFVIA KDLFLEGPFP WPIWRPYPEP TTYIQRLELT LFCFTFLEIF
LSGSTAITAY RMKRLQAEDK DDTPFVPDTP MELKGLSLGP PPSYKDVAQG HSSSDTGRAL
ATSSGLLLAS DSFHQALLHT GPRTLRK
