M4A13_HUMAN
ID M4A13_HUMAN Reviewed; 152 AA.
AC Q5J8X5; B2RTS9; Q5J8X3; Q5J8X4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Membrane-spanning 4-domains subfamily A member 13;
DE AltName: Full=Testis-expressed transmembrane protein 4;
GN Name=MS4A13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
RA Hulett M.D., Hornby J.R., Halliday D.C.T.;
RT "Isolation and characterization of a novel human four-transmembrane gene of
RT the MS4A family expressed in the testis.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT VAL-7.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in signal transduction as a component of a
CC multimeric receptor complex. {ECO:0000250}.
CC -!- INTERACTION:
CC Q5J8X5; P41181: AQP2; NbExp=3; IntAct=EBI-12070086, EBI-12701138;
CC Q5J8X5; Q13520: AQP6; NbExp=3; IntAct=EBI-12070086, EBI-13059134;
CC Q5J8X5; P07307-3: ASGR2; NbExp=3; IntAct=EBI-12070086, EBI-12808270;
CC Q5J8X5; O15342: ATP6V0E1; NbExp=3; IntAct=EBI-12070086, EBI-12935759;
CC Q5J8X5; O76090-4: BEST1; NbExp=3; IntAct=EBI-12070086, EBI-18631885;
CC Q5J8X5; Q13323: BIK; NbExp=3; IntAct=EBI-12070086, EBI-700794;
CC Q5J8X5; Q8N350-4: CBARP; NbExp=3; IntAct=EBI-12070086, EBI-19051169;
CC Q5J8X5; P11912: CD79A; NbExp=3; IntAct=EBI-12070086, EBI-7797864;
CC Q5J8X5; O95471: CLDN7; NbExp=3; IntAct=EBI-12070086, EBI-740744;
CC Q5J8X5; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-12070086, EBI-6942903;
CC Q5J8X5; Q68CJ9: CREB3L3; NbExp=3; IntAct=EBI-12070086, EBI-852194;
CC Q5J8X5; Q9Y4D2: DAGLA; NbExp=3; IntAct=EBI-12070086, EBI-12808806;
CC Q5J8X5; Q15125: EBP; NbExp=3; IntAct=EBI-12070086, EBI-3915253;
CC Q5J8X5; Q92838: EDA; NbExp=3; IntAct=EBI-12070086, EBI-529425;
CC Q5J8X5; O14944: EREG; NbExp=3; IntAct=EBI-12070086, EBI-17272224;
CC Q5J8X5; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-12070086, EBI-781551;
CC Q5J8X5; Q9H8M9: EVA1A; NbExp=3; IntAct=EBI-12070086, EBI-715362;
CC Q5J8X5; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-12070086, EBI-18304435;
CC Q5J8X5; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-12070086, EBI-18938272;
CC Q5J8X5; O15552: FFAR2; NbExp=3; IntAct=EBI-12070086, EBI-2833872;
CC Q5J8X5; P35212: GJA4; NbExp=3; IntAct=EBI-12070086, EBI-6918707;
CC Q5J8X5; P36382: GJA5; NbExp=3; IntAct=EBI-12070086, EBI-750433;
CC Q5J8X5; P48165: GJA8; NbExp=3; IntAct=EBI-12070086, EBI-17458373;
CC Q5J8X5; P08034: GJB1; NbExp=3; IntAct=EBI-12070086, EBI-17565645;
CC Q5J8X5; O95377: GJB5; NbExp=3; IntAct=EBI-12070086, EBI-3909454;
CC Q5J8X5; O95452: GJB6; NbExp=3; IntAct=EBI-12070086, EBI-13345609;
CC Q5J8X5; Q8NFK1: GJC3; NbExp=3; IntAct=EBI-12070086, EBI-20110678;
CC Q5J8X5; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-12070086, EBI-13345167;
CC Q5J8X5; Q9BSE4: HERPUD2; NbExp=3; IntAct=EBI-12070086, EBI-2868124;
CC Q5J8X5; Q96MG2: JSRP1; NbExp=3; IntAct=EBI-12070086, EBI-11305455;
CC Q5J8X5; Q86W47: KCNMB4; NbExp=3; IntAct=EBI-12070086, EBI-19112227;
CC Q5J8X5; P26715: KLRC1; NbExp=3; IntAct=EBI-12070086, EBI-9018187;
CC Q5J8X5; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-12070086, EBI-2820517;
CC Q5J8X5; Q96PB8: LRRC3B; NbExp=3; IntAct=EBI-12070086, EBI-17775622;
CC Q5J8X5; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-12070086, EBI-6163737;
CC Q5J8X5; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-12070086, EBI-12806656;
CC Q5J8X5; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-12070086, EBI-748927;
CC Q5J8X5; Q2M2E3: ODF4; NbExp=3; IntAct=EBI-12070086, EBI-12382569;
CC Q5J8X5; Q9H5K3: POMK; NbExp=3; IntAct=EBI-12070086, EBI-11337900;
CC Q5J8X5; O60894: RAMP1; NbExp=3; IntAct=EBI-12070086, EBI-962893;
CC Q5J8X5; Q9UBD6: RHCG; NbExp=3; IntAct=EBI-12070086, EBI-15853497;
CC Q5J8X5; Q96GF1: RNF185; NbExp=3; IntAct=EBI-12070086, EBI-2340249;
CC Q5J8X5; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-12070086, EBI-17247926;
CC Q5J8X5; Q9Y666-2: SLC12A7; NbExp=3; IntAct=EBI-12070086, EBI-12854384;
CC Q5J8X5; Q9UKG4: SLC13A4; NbExp=3; IntAct=EBI-12070086, EBI-12808018;
CC Q5J8X5; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-12070086, EBI-17595455;
CC Q5J8X5; Q9BRI3: SLC30A2; NbExp=6; IntAct=EBI-12070086, EBI-8644112;
CC Q5J8X5; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-12070086, EBI-12898013;
CC Q5J8X5; P30825: SLC7A1; NbExp=3; IntAct=EBI-12070086, EBI-4289564;
CC Q5J8X5; Q9NPE6: SPAG4; NbExp=3; IntAct=EBI-12070086, EBI-10819434;
CC Q5J8X5; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-12070086, EBI-17280858;
CC Q5J8X5; Q0VAB0: TBXA2R; NbExp=3; IntAct=EBI-12070086, EBI-18271435;
CC Q5J8X5; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-12070086, EBI-12947623;
CC Q5J8X5; Q96CE8: TM4SF18; NbExp=3; IntAct=EBI-12070086, EBI-13351685;
CC Q5J8X5; Q7Z404-3: TMC4; NbExp=3; IntAct=EBI-12070086, EBI-23725088;
CC Q5J8X5; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12070086, EBI-8638294;
CC Q5J8X5; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-12070086, EBI-10982110;
CC Q5J8X5; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-12070086, EBI-18178701;
CC Q5J8X5; Q96NL1: TMEM74; NbExp=3; IntAct=EBI-12070086, EBI-10292091;
CC Q5J8X5; Q9H7M9: VSIR; NbExp=3; IntAct=EBI-12070086, EBI-744988;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5J8X5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5J8X5-2; Sequence=VSP_030476;
CC Name=3;
CC IsoId=Q5J8X5-3; Sequence=VSP_030477;
CC -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR EMBL; AY324188; AAQ94112.1; -; mRNA.
DR EMBL; AY324189; AAQ94113.1; -; mRNA.
DR EMBL; AY324190; AAQ94114.1; -; mRNA.
DR EMBL; AP001034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC140799; AAI40800.1; -; mRNA.
DR CCDS; CCDS31571.1; -. [Q5J8X5-1]
DR CCDS; CCDS41653.1; -. [Q5J8X5-2]
DR CCDS; CCDS60801.1; -. [Q5J8X5-3]
DR RefSeq; NP_001012417.2; NM_001012417.2. [Q5J8X5-1]
DR RefSeq; NP_001094379.1; NM_001100909.1. [Q5J8X5-2]
DR RefSeq; NP_001265249.1; NM_001278320.1. [Q5J8X5-3]
DR AlphaFoldDB; Q5J8X5; -.
DR SMR; Q5J8X5; -.
DR BioGRID; 139008; 67.
DR IntAct; Q5J8X5; 60.
DR BioMuta; MS4A13; -.
DR DMDM; 334302831; -.
DR PaxDb; Q5J8X5; -.
DR PeptideAtlas; Q5J8X5; -.
DR PRIDE; Q5J8X5; -.
DR Antibodypedia; 50523; 58 antibodies from 13 providers.
DR DNASU; 503497; -.
DR Ensembl; ENST00000378185.6; ENSP00000367427.2; ENSG00000204979.8. [Q5J8X5-2]
DR Ensembl; ENST00000378186.7; ENSP00000367428.2; ENSG00000204979.8. [Q5J8X5-1]
DR Ensembl; ENST00000437058.6; ENSP00000415535.2; ENSG00000204979.8. [Q5J8X5-3]
DR GeneID; 503497; -.
DR KEGG; hsa:503497; -.
DR MANE-Select; ENST00000378186.7; ENSP00000367428.2; NM_001012417.3; NP_001012417.2.
DR UCSC; uc001nps.4; human. [Q5J8X5-1]
DR CTD; 503497; -.
DR GeneCards; MS4A13; -.
DR HGNC; HGNC:16674; MS4A13.
DR HPA; ENSG00000204979; Tissue enriched (testis).
DR neXtProt; NX_Q5J8X5; -.
DR OpenTargets; ENSG00000204979; -.
DR PharmGKB; PA142671314; -.
DR VEuPathDB; HostDB:ENSG00000204979; -.
DR eggNOG; ENOG502RTZG; Eukaryota.
DR GeneTree; ENSGT00390000015662; -.
DR HOGENOM; CLU_144238_0_0_1; -.
DR InParanoid; Q5J8X5; -.
DR OMA; YKNYGQA; -.
DR OrthoDB; 1515352at2759; -.
DR PhylomeDB; Q5J8X5; -.
DR TreeFam; TF353242; -.
DR PathwayCommons; Q5J8X5; -.
DR SignaLink; Q5J8X5; -.
DR BioGRID-ORCS; 503497; 6 hits in 985 CRISPR screens.
DR ChiTaRS; MS4A13; human.
DR GenomeRNAi; 503497; -.
DR Pharos; Q5J8X5; Tdark.
DR PRO; PR:Q5J8X5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q5J8X5; protein.
DR Bgee; ENSG00000204979; Expressed in testis and 4 other tissues.
DR ExpressionAtlas; Q5J8X5; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR030417; MS4A.
DR PANTHER; PTHR23320; PTHR23320; 1.
DR Pfam; PF04103; CD20; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..152
FT /note="Membrane-spanning 4-domains subfamily A member 13"
FT /id="PRO_0000315055"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 44..102
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_030477"
FT VAR_SEQ 63..102
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_030476"
FT VARIANT 3
FT /note="G -> D (in dbSNP:rs55756397)"
FT /id="VAR_062124"
FT VARIANT 7
FT /note="I -> V (in dbSNP:rs10736706)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_062125"
FT VARIANT 58
FT /note="P -> L (in dbSNP:rs6591595)"
FT /id="VAR_057654"
FT CONFLICT 102
FT /note="A -> V (in Ref. 1; AAQ94112)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 152 AA; 17307 MW; 15E9C8DB4307E608 CRC64;
MIGIFHIFMW YFLLVLYMGQ IKGAFGTYEP VTYKTGCTLW GIFFIIAGVF LIRVTKYPTR
SGIISTLIIN IICIITTITA VTLTIIELSH FNSVSYRNYG QAKLGREVSR ILLFFYGLEF
SIALTHSIYS CSNLFRRQND LTSVTEEAES TP
