M4A13_MOUSE
ID M4A13_MOUSE Reviewed; 203 AA.
AC Q5FWC3; Q717T1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Membrane-spanning 4-domains subfamily A member 13;
DE AltName: Full=Testis-expressed transmembrane protein 4.2;
DE Short=Tetm4.2;
GN Name=Ms4a13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RA Hulett M.D., Hornby J.R., Halliday D.C.T.;
RT "Isolation and characterisation of two novel mouse four-transmembrane genes
RT expressed specifically in the testis.";
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in signal transduction as a component of a
CC multimeric receptor complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5FWC3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5FWC3-2; Sequence=VSP_030478;
CC -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-22 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AF544402; AAQ11744.1; -; mRNA.
DR EMBL; BC089483; AAH89483.1; -; mRNA.
DR CCDS; CCDS29595.1; -. [Q5FWC3-1]
DR CCDS; CCDS84420.1; -. [Q5FWC3-2]
DR RefSeq; NP_001334364.1; NM_001347435.1. [Q5FWC3-2]
DR RefSeq; NP_937867.2; NM_198224.3. [Q5FWC3-1]
DR AlphaFoldDB; Q5FWC3; -.
DR SMR; Q5FWC3; -.
DR PaxDb; Q5FWC3; -.
DR PRIDE; Q5FWC3; -.
DR ProteomicsDB; 295753; -. [Q5FWC3-1]
DR ProteomicsDB; 295754; -. [Q5FWC3-2]
DR Antibodypedia; 50523; 58 antibodies from 13 providers.
DR DNASU; 73466; -.
DR Ensembl; ENSMUST00000073380; ENSMUSP00000073095; ENSMUSG00000057240. [Q5FWC3-1]
DR Ensembl; ENSMUST00000188464; ENSMUSP00000140293; ENSMUSG00000057240. [Q5FWC3-2]
DR GeneID; 73466; -.
DR KEGG; mmu:73466; -.
DR UCSC; uc008gru.1; mouse. [Q5FWC3-1]
DR UCSC; uc008grv.1; mouse. [Q5FWC3-2]
DR CTD; 503497; -.
DR MGI; MGI:1920716; Ms4a13.
DR VEuPathDB; HostDB:ENSMUSG00000057240; -.
DR eggNOG; ENOG502RTZG; Eukaryota.
DR GeneTree; ENSGT00390000015662; -.
DR HOGENOM; CLU_1348559_0_0_1; -.
DR InParanoid; Q5FWC3; -.
DR OrthoDB; 1515352at2759; -.
DR PhylomeDB; Q5FWC3; -.
DR TreeFam; TF353242; -.
DR BioGRID-ORCS; 73466; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Ms4a13; mouse.
DR PRO; PR:Q5FWC3; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q5FWC3; protein.
DR Bgee; ENSMUSG00000057240; Expressed in spermatid and 7 other tissues.
DR Genevisible; Q5FWC3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR030417; MS4A.
DR PANTHER; PTHR23320; PTHR23320; 1.
DR Pfam; PF04103; CD20; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Receptor; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..203
FT /note="Membrane-spanning 4-domains subfamily A member 13"
FT /id="PRO_0000315056"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 156..184
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_030478"
SQ SEQUENCE 203 AA; 22802 MW; F4596B6013EC4768 CRC64;
MECRNPKVSS ANITVLGVIQ IMIGIYHVLM WYFLLLLYMG QIKGVFGTYE PVTYKMGTSL
WGFAFVISGA FTVKAAKYQS RHMILCTMSL NILCIIITIV AASLTIVELS HFRSVSYRNY
GQAKLGREVS RVLLCSYPLE FAIALLYSIS SCAYLPLSSI VKSLVRKTWR LSSLAAWRQM
IWLEAGNQEE TLESVTEVVE GNS
