M4A15_HUMAN
ID M4A15_HUMAN Reviewed; 240 AA.
AC Q8N5U1; A9UJY6; A9UJY7; F2Z2J5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Membrane-spanning 4-domains subfamily A member 15;
GN Name=MS4A15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), AND VARIANT ARG-47.
RA Liang Y., Tedder T.F.;
RT "MS4A genes.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in signal transduction as a component of a
CC multimeric receptor complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8N5U1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N5U1-2; Sequence=VSP_031669;
CC Name=3;
CC IsoId=Q8N5U1-3; Sequence=VSP_053907;
CC -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR EMBL; AY584608; AAV91957.1; -; mRNA.
DR EMBL; AY584609; AAV91958.1; -; mRNA.
DR EMBL; AP004243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471076; EAW73898.1; -; Genomic_DNA.
DR EMBL; BC031610; AAH31610.1; -; mRNA.
DR CCDS; CCDS44617.1; -. [Q8N5U1-1]
DR CCDS; CCDS60802.1; -. [Q8N5U1-3]
DR CCDS; CCDS7991.1; -. [Q8N5U1-2]
DR RefSeq; NP_001092305.1; NM_001098835.1. [Q8N5U1-1]
DR RefSeq; NP_001265171.1; NM_001278242.1. [Q8N5U1-3]
DR RefSeq; NP_689930.1; NM_152717.2. [Q8N5U1-2]
DR RefSeq; XP_006718522.1; XM_006718459.3. [Q8N5U1-2]
DR RefSeq; XP_011543114.1; XM_011544812.2. [Q8N5U1-1]
DR RefSeq; XP_011543116.1; XM_011544814.1. [Q8N5U1-2]
DR AlphaFoldDB; Q8N5U1; -.
DR SMR; Q8N5U1; -.
DR BioGRID; 128615; 38.
DR STRING; 9606.ENSP00000386022; -.
DR iPTMnet; Q8N5U1; -.
DR PhosphoSitePlus; Q8N5U1; -.
DR BioMuta; MS4A15; -.
DR DMDM; 182705272; -.
DR PaxDb; Q8N5U1; -.
DR PeptideAtlas; Q8N5U1; -.
DR PRIDE; Q8N5U1; -.
DR Antibodypedia; 27949; 58 antibodies from 10 providers.
DR DNASU; 219995; -.
DR Ensembl; ENST00000337911.8; ENSP00000338692.4; ENSG00000166961.15. [Q8N5U1-2]
DR Ensembl; ENST00000405633.4; ENSP00000386022.3; ENSG00000166961.15. [Q8N5U1-1]
DR Ensembl; ENST00000528170.5; ENSP00000434165.1; ENSG00000166961.15. [Q8N5U1-3]
DR GeneID; 219995; -.
DR KEGG; hsa:219995; -.
DR MANE-Select; ENST00000405633.4; ENSP00000386022.3; NM_001098835.2; NP_001092305.1.
DR UCSC; uc001npx.3; human. [Q8N5U1-1]
DR CTD; 219995; -.
DR GeneCards; MS4A15; -.
DR HGNC; HGNC:28573; MS4A15.
DR HPA; ENSG00000166961; Tissue enriched (lung).
DR neXtProt; NX_Q8N5U1; -.
DR OpenTargets; ENSG00000166961; -.
DR PharmGKB; PA134959869; -.
DR VEuPathDB; HostDB:ENSG00000166961; -.
DR eggNOG; ENOG502S2RH; Eukaryota.
DR GeneTree; ENSGT00940000162324; -.
DR HOGENOM; CLU_091032_1_1_1; -.
DR InParanoid; Q8N5U1; -.
DR OMA; ERSHTSC; -.
DR OrthoDB; 1463152at2759; -.
DR PhylomeDB; Q8N5U1; -.
DR TreeFam; TF335157; -.
DR PathwayCommons; Q8N5U1; -.
DR BioGRID-ORCS; 219995; 9 hits in 1062 CRISPR screens.
DR GenomeRNAi; 219995; -.
DR Pharos; Q8N5U1; Tdark.
DR PRO; PR:Q8N5U1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8N5U1; protein.
DR Bgee; ENSG00000166961; Expressed in right lung and 35 other tissues.
DR ExpressionAtlas; Q8N5U1; baseline and differential.
DR Genevisible; Q8N5U1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR030417; MS4A.
DR PANTHER; PTHR23320; PTHR23320; 1.
DR Pfam; PF04103; CD20; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Receptor; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..240
FT /note="Membrane-spanning 4-domains subfamily A member 15"
FT /id="PRO_0000320577"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..93
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031669"
FT VAR_SEQ 76..116
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_053907"
FT VARIANT 20
FT /note="S -> G (in dbSNP:rs12363342)"
FT /id="VAR_053524"
FT VARIANT 47
FT /note="L -> R (in dbSNP:rs1032939)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_053525"
FT CONFLICT 225
FT /note="S -> P (in Ref. 1; AAV91957)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 240 AA; 25050 MW; 1676819E39AEF4E7 CRC64;
MSAAPASNGV FVVIPPNNAS GLCPPPAILP TSMCQPPGIM QFEEPPLGAQ TPRATQPPDL
RPVETFLTGE PKVLGTVQIL IGLIHLGFGS VLLMVRRGHV GIFFIEGGVP FWGGACFIIS
GSLSVAAEKN HTSCLVRSSL GTNILSVMAA FAGTAILLMD FGVTNRDVDR GYLAVLTIFT
VLEFFTAVIA MHFGCQAIHA QASAPVIFLP NAFSADFNIP SPAASAPPAY DNVAYAQGVV
