ID   M4A18_BOVIN             Reviewed;         337 AA.
AC   A6QPF4;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Membrane-spanning 4-domains subfamily A member 18;
GN   Name=MS4A18;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR   EMBL; BC149291; AAI49292.1; -; mRNA.
DR   RefSeq; NP_001095462.1; NM_001101992.2.
DR   RefSeq; XP_005226906.1; XM_005226849.3.
DR   RefSeq; XP_010819270.1; XM_010820968.2.
DR   AlphaFoldDB; A6QPF4; -.
DR   SMR; A6QPF4; -.
DR   STRING; 9913.ENSBTAP00000044342; -.
DR   PaxDb; A6QPF4; -.
DR   Ensembl; ENSBTAT00000047112; ENSBTAP00000044342; ENSBTAG00000038312.
DR   GeneID; 514287; -.
DR   KEGG; bta:514287; -.
DR   CTD; 728588; -.
DR   VEuPathDB; HostDB:ENSBTAG00000038312; -.
DR   VGNC; VGNC:31684; MS4A18.
DR   eggNOG; ENOG502RZ20; Eukaryota.
DR   GeneTree; ENSGT00940000163489; -.
DR   HOGENOM; CLU_071067_0_0_1; -.
DR   InParanoid; A6QPF4; -.
DR   OMA; KVIQCDT; -.
DR   OrthoDB; 892598at2759; -.
DR   TreeFam; TF335157; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000038312; Expressed in jejunum and 27 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR007237; CD20-like.
DR   InterPro; IPR030417; MS4A.
DR   PANTHER; PTHR23320; PTHR23320; 1.
DR   Pfam; PF04103; CD20; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..337
FT                   /note="Membrane-spanning 4-domains subfamily A member 18"
FT                   /id="PRO_0000395339"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          101..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   337 AA;  35566 MW;  AC743FE9B5B2F440 CRC64;
     MMEQGVGANT VPGVTAPGNV YMIQARNPVA PGSKGQPVGM ATYLTSRVTE SDAGRANLQT
     PRVVIQNPAE VNATQGPPTA LQHPTAVASL QTPPGEIQYS LGTTDLQTQP GGPQNPPTCA
     PGPMYTSNQF QWNMPFGSSF TFDPKKFIKD EVRTLGAIQI LIGLTHIFTA INPSLYRQYS
     YSAISGYLVW GGIFFIISGS LSVEAEKDRS SCMVHGSVGM NVVSAIVSLA GVLLLLVDLI
     RNPVIDVKTV SGGLLPFVLL EFCLTCVVSH FGCQATCWNQ FVNRTEVPTI VIANPANTPT
     GPFNATYSTT GHVNVITSSA NPTSPTNAAA MVPPVPS