ID   M4A18_HUMAN             Reviewed;         400 AA.
AC   Q3C1V0; H0YCH9;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 3.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Membrane-spanning 4-domains subfamily A member 18;
GN   Name=MS4A18;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 184-230.
RA   Totoki Y., Yada T., Sakaki Y., Takeda T.;
RT   "Identification of novel human genes predicted by combining multiple gene-
RT   finders.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR   EMBL; AP004243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB231761; BAE46897.1; -; mRNA.
DR   AlphaFoldDB; Q3C1V0; -.
DR   SMR; Q3C1V0; -.
DR   STRING; 9606.ENSP00000431607; -.
DR   iPTMnet; Q3C1V0; -.
DR   PhosphoSitePlus; Q3C1V0; -.
DR   BioMuta; ENSG00000214782; -.
DR   BioMuta; HGNC:37636; -.
DR   DMDM; 300681243; -.
DR   PaxDb; Q3C1V0; -.
DR   PeptideAtlas; Q3C1V0; -.
DR   PRIDE; Q3C1V0; -.
DR   ProteomicsDB; 61681; -.
DR   Antibodypedia; 50555; 10 antibodies from 6 providers.
DR   Ensembl; ENST00000529108.5; ENSP00000431607.2; ENSG00000214782.7.
DR   UCSC; uc058bvj.1; human.
DR   GeneCards; MS4A18; -.
DR   HGNC; HGNC:37636; MS4A18.
DR   HPA; ENSG00000214782; Group enriched (breast, intestine).
DR   neXtProt; NX_Q3C1V0; -.
DR   OpenTargets; ENSG00000214782; -.
DR   VEuPathDB; HostDB:ENSG00000214782; -.
DR   eggNOG; ENOG502RZ20; Eukaryota.
DR   GeneTree; ENSGT00940000163489; -.
DR   HOGENOM; CLU_071067_0_0_1; -.
DR   InParanoid; Q3C1V0; -.
DR   OMA; KVIQCDT; -.
DR   PhylomeDB; Q3C1V0; -.
DR   TreeFam; TF335157; -.
DR   Pharos; Q3C1V0; Tdark.
DR   PRO; PR:Q3C1V0; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q3C1V0; protein.
DR   Bgee; ENSG00000214782; Expressed in duodenum and 11 other tissues.
DR   ExpressionAtlas; Q3C1V0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR007237; CD20-like.
DR   InterPro; IPR030417; MS4A.
DR   PANTHER; PTHR23320; PTHR23320; 1.
DR   Pfam; PF04103; CD20; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..400
FT                   /note="Membrane-spanning 4-domains subfamily A member 18"
FT                   /id="PRO_0000395340"
FT   TRANSMEM        156..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          318..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   400 AA;  42176 MW;  9AEC6C8483BBD26A CRC64;
     MTEQVIGANS VPGIIAPDNV HVIQPSNPVA SGNHLQPSEV TTYPISPKVI HCDTGRANLQ
     NLLVVNQNSA AGVQSQPIGY QRQYPVGTAS LQTVPGVIQY TQGTTNLQTW PGDLQNPLNA
     NPGLTHTSNS SQWNTSFASF TSFNPKKFIN EEVRTLGVSA IQILIGLTHI FSAINPVLYY
     YPFVTWLSGY PLWGGLSYIV SGSLSVWAAK DPSPCVVNSS ISFNIISALF AFAGIFIIIT
     DLSLYYVTTY SKAVSGGLLP FALLEFILTC VVSHFGCQAT CCRQFENVAV IPTVFSFNPA
     NTTTSPVNAT TGPVNAATGP VSATNGPVNT TIHPVNTTTS PVNTTTSPVN VTTGPVNANI
     GPVNVTTGPV NTTTAPAKAT TSCVNAIHTS NVPPNPRTKK