ID   M4A4D_MOUSE             Reviewed;         225 AA.
AC   Q99N05;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Membrane-spanning 4-domains subfamily A member 4D;
GN   Name=Ms4a4d;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung;
RX   PubMed=11401424; DOI=10.1006/geno.2000.6472;
RA   Liang Y., Tedder T.F.;
RT   "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene
RT   family: sixteen new MS4A family members expressed in human and mouse.";
RL   Genomics 72:119-127(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in signal transduction as a component of a
CC       multimeric receptor complex.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in thymus, spleen, peripheral lymph node,
CC       liver, kidney, heart, colon, lung, and testes.
CC   -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR   EMBL; AF237915; AAK37598.1; -; mRNA.
DR   EMBL; BC069842; AAH69842.1; -; mRNA.
DR   CCDS; CCDS29602.1; -.
DR   RefSeq; NP_079934.2; NM_025658.4.
DR   AlphaFoldDB; Q99N05; -.
DR   SMR; Q99N05; -.
DR   STRING; 10090.ENSMUSP00000025581; -.
DR   MaxQB; Q99N05; -.
DR   PaxDb; Q99N05; -.
DR   PRIDE; Q99N05; -.
DR   ProteomicsDB; 295755; -.
DR   DNASU; 66607; -.
DR   Ensembl; ENSMUST00000025581; ENSMUSP00000025581; ENSMUSG00000024678.
DR   GeneID; 66607; -.
DR   KEGG; mmu:66607; -.
DR   UCSC; uc008gsl.1; mouse.
DR   CTD; 66607; -.
DR   MGI; MGI:1913857; Ms4a4d.
DR   VEuPathDB; HostDB:ENSMUSG00000024678; -.
DR   eggNOG; ENOG502S3XD; Eukaryota.
DR   GeneTree; ENSGT00940000155376; -.
DR   HOGENOM; CLU_091032_3_1_1; -.
DR   InParanoid; Q99N05; -.
DR   OMA; GITIFMP; -.
DR   OrthoDB; 1178983at2759; -.
DR   PhylomeDB; Q99N05; -.
DR   TreeFam; TF335157; -.
DR   BioGRID-ORCS; 66607; 4 hits in 72 CRISPR screens.
DR   ChiTaRS; Ms4a4d; mouse.
DR   PRO; PR:Q99N05; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; Q99N05; protein.
DR   Bgee; ENSMUSG00000024678; Expressed in paneth cell and 125 other tissues.
DR   Genevisible; Q99N05; MM.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0044853; C:plasma membrane raft; ISO:MGI.
DR   InterPro; IPR007237; CD20-like.
DR   InterPro; IPR030417; MS4A.
DR   PANTHER; PTHR23320; PTHR23320; 1.
DR   Pfam; PF04103; CD20; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..225
FT                   /note="Membrane-spanning 4-domains subfamily A member 4D"
FT                   /id="PRO_0000158635"
FT   TOPO_DOM        1..42
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..73
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        95..113
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        135..148
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        170..225
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   225 AA;  23859 MW;  9D3B2678787039B4 CRC64;
     MQGLAQTTMA VVPGGAPPSE NSVIKSQMWN KNKEKFLKGE PKVLGAIQVM IAFINFSLGI
     IIILNRVSER FMSVLLLAPF WGSIMFIFSG SLSIAAGVKP TKAMIISSLS VNTISSVLAV
     AASIIGVISV ISGVFRQFRS QPAIASLDVL MTILNMLEFC IAVSVSAFGC KASCCNSSEV
     LVVLPSNSAV TVTAPPMILQ PLPPSECQGK NVPENLYRNQ PGEIV