M4A4E_HUMAN
ID M4A4E_HUMAN Reviewed; 132 AA.
AC Q96PG1; Q3C1W1; Q3C1W3; Q3C1W4;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Putative membrane-spanning 4-domains subfamily A member 4E;
GN Name=MS4A4E;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11486273; DOI=10.1007/s002510100339;
RA Liang Y., Buckley T.R., Tu L., Langdon S.D., Tedder T.F.;
RT "Structural organization of the human MS4A gene cluster on chromosome
RT 11q12.";
RL Immunogenetics 53:357-368(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-132 (ISOFORMS 1; 2 AND 3).
RA Totoki Y., Yada T., Sakaki Y., Takeda T.;
RT "Identification of novel human genes predicted by combining multiple gene-
RT finders.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96PG1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96PG1-2; Sequence=VSP_033858;
CC Name=3;
CC IsoId=Q96PG1-3; Sequence=VSP_033859;
CC -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL07363.1; Type=Miscellaneous discrepancy; Note=Intron retention. The entire sequence corresponds to part of an intron.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DC379793; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF354936; AAL07363.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB231725; BAE46883.1; -; mRNA.
DR EMBL; AB231726; BAE46884.1; -; mRNA.
DR EMBL; AB231727; BAE46885.1; -; mRNA.
DR EMBL; AB231728; BAE46886.1; -; mRNA.
DR AlphaFoldDB; Q96PG1; -.
DR STRING; 9606.ENSP00000381956; -.
DR BioMuta; MS4A4E; -.
DR DMDM; 189047113; -.
DR PeptideAtlas; Q96PG1; -.
DR PRIDE; Q96PG1; -.
DR Antibodypedia; 50251; 11 antibodies from 6 providers.
DR Ensembl; ENST00000398984.6; ENSP00000381954.2; ENSG00000214787.11. [Q96PG1-1]
DR UCSC; uc001nox.3; human. [Q96PG1-1]
DR GeneCards; MS4A4E; -.
DR HGNC; HGNC:14284; MS4A4E.
DR HPA; ENSG00000214787; Low tissue specificity.
DR MIM; 608401; gene.
DR neXtProt; NX_Q96PG1; -.
DR OpenTargets; ENSG00000214787; -.
DR VEuPathDB; HostDB:ENSG00000214787; -.
DR eggNOG; ENOG502S3XD; Eukaryota.
DR GeneTree; ENSGT00940000155376; -.
DR HOGENOM; CLU_2454059_0_0_1; -.
DR InParanoid; Q96PG1; -.
DR OrthoDB; 1483992at2759; -.
DR PhylomeDB; Q96PG1; -.
DR ChiTaRS; MS4A4E; human.
DR Pharos; Q96PG1; Tdark.
DR PRO; PR:Q96PG1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96PG1; protein.
DR Bgee; ENSG00000214787; Expressed in monocyte and 101 other tissues.
DR ExpressionAtlas; Q96PG1; baseline and differential.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR030417; MS4A.
DR PANTHER; PTHR23320; PTHR23320; 1.
DR Pfam; PF04103; CD20; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Receptor; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..132
FT /note="Putative membrane-spanning 4-domains subfamily A
FT member 4E"
FT /id="PRO_0000158636"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 49..91
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_033858"
FT VAR_SEQ 50..132
FT /note="VRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMYPYQLQQELE
FT QQKVWNYLKNLSWRIMGSYLCFGERSELKPL -> LCGHKFSTHSVSLSVAAGIRTTKG
FT LELSEEFKLENNGIIFVFWREIRVETTIRRQVRRLLK (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_033859"
FT CONFLICT 10..11
FT /note="TT -> AM (in Ref. 3; BAE46883)"
FT /evidence="ECO:0000305"
FT CONFLICT 17
FT /note="D -> G (in Ref. 3; BAE46883)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 132 AA; 15209 MW; EA0A274F8F576A31 CRC64;
MTTMQGMEQT TPGAGPDVPQ LGNIDVIHSY LCKGLQEKFF KRKPKVLGVV RILIALMSLS
MGIIMMCVAF SSYEEHPIFV YVAYTIWGSV MYPYQLQQEL EQQKVWNYLK NLSWRIMGSY
LCFGERSELK PL
