M4A6B_MOUSE
ID M4A6B_MOUSE Reviewed; 244 AA.
AC Q99N09; Q8BK83; Q9D8W9;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Membrane-spanning 4-domains subfamily A member 6B;
GN Name=Ms4a6b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetus;
RX PubMed=11401424; DOI=10.1006/geno.2000.6472;
RA Liang Y., Tedder T.F.;
RT "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene
RT family: sixteen new MS4A family members expressed in human and mouse.";
RL Genomics 72:119-127(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in signal transduction as a component of a
CC multimeric receptor complex.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in thymus, spleen, and
CC peripheral lymph nodes, with less abundant levels in non-lymphoid
CC tissues.
CC -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR EMBL; AF237909; AAK37418.1; -; mRNA.
DR EMBL; AK007613; BAB25136.1; -; mRNA.
DR EMBL; AK075671; BAC35886.1; -; mRNA.
DR EMBL; BC027425; AAH27425.1; -; mRNA.
DR CCDS; CCDS29601.1; -.
DR RefSeq; NP_081485.2; NM_027209.3.
DR AlphaFoldDB; Q99N09; -.
DR STRING; 10090.ENSMUSP00000124685; -.
DR EPD; Q99N09; -.
DR MaxQB; Q99N09; -.
DR PaxDb; Q99N09; -.
DR PRIDE; Q99N09; -.
DR ProteomicsDB; 287283; -.
DR DNASU; 69774; -.
DR Ensembl; ENSMUST00000025580; ENSMUSP00000025580; ENSMUSG00000024677.
DR Ensembl; ENSMUST00000163078; ENSMUSP00000124685; ENSMUSG00000024677.
DR GeneID; 69774; -.
DR KEGG; mmu:69774; -.
DR UCSC; uc008gsk.1; mouse.
DR CTD; 69774; -.
DR MGI; MGI:1917024; Ms4a6b.
DR VEuPathDB; HostDB:ENSMUSG00000024677; -.
DR eggNOG; ENOG502SUQB; Eukaryota.
DR GeneTree; ENSGT00940000162688; -.
DR HOGENOM; CLU_089673_1_0_1; -.
DR InParanoid; Q99N09; -.
DR OMA; FHKSTIT; -.
DR OrthoDB; 1275704at2759; -.
DR PhylomeDB; Q99N09; -.
DR TreeFam; TF335157; -.
DR BioGRID-ORCS; 69774; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Ms4a6b; mouse.
DR PRO; PR:Q99N09; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q99N09; protein.
DR Bgee; ENSMUSG00000024677; Expressed in stroma of bone marrow and 169 other tissues.
DR ExpressionAtlas; Q99N09; baseline and differential.
DR Genevisible; Q99N09; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; ISO:MGI.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR030417; MS4A.
DR InterPro; IPR030427; MS4A6A-E.
DR PANTHER; PTHR23320; PTHR23320; 1.
DR PANTHER; PTHR23320:SF120; PTHR23320:SF120; 1.
DR Pfam; PF04103; CD20; 1.
PE 2: Evidence at transcript level;
KW Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..244
FT /note="Membrane-spanning 4-domains subfamily A member 6B"
FT /id="PRO_0000158639"
FT TOPO_DOM 1..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..84
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..176
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 65
FT /note="I -> L (in Ref. 2; BAB25136)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="A -> S (in Ref. 2; BAC35886)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 244 AA; 26860 MW; 4F822BB7D0DB88CE CRC64;
MIPQVVTSET VAMISPNGMS LPQTDKPQPF HQWQDSLKKH LKAEIKVMAA IQIMCAVMVL
SLGIILASVP SNLHFTSVFS VLLKSGYPFI GALFFIVSGI LSIVTETKST KILVDSSLTL
NILSVSFAFM GIIIISVSLA GLHPASEQCL QSKELRPTEY HYYQFLDRNE CFAAKSVLAG
VFSLMLISTM LELGLAVLTA MLWWKQSHSN IPGNVMFLPH SSNNDSNMES KVLCNPSYEE
QLVC
