M4A6C_MOUSE
ID M4A6C_MOUSE Reviewed; 217 AA.
AC Q99N08; Q3U8E1; Q8BVZ4; Q9D7Z9;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Membrane-spanning 4-domains subfamily A member 6C;
GN Name=Ms4a6c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Fetus;
RX PubMed=11401424; DOI=10.1006/geno.2000.6472;
RA Liang Y., Tedder T.F.;
RT "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene
RT family: sixteen new MS4A family members expressed in human and mouse.";
RL Genomics 72:119-127(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be involved in signal transduction as a component of a
CC multimeric receptor complex.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q99N08-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q99N08-2; Sequence=VSP_007385, VSP_007386;
CC -!- TISSUE SPECIFICITY: Expressed only by thymus, spleen, peripheral lymph
CC node and bone marrow.
CC -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR EMBL; AF237910; AAK37419.1; -; mRNA.
DR EMBL; AK008652; BAB25808.1; -; mRNA.
DR EMBL; AK075852; BAC36004.1; -; mRNA.
DR EMBL; AK150397; BAE29524.1; -; mRNA.
DR EMBL; AK152258; BAE31077.1; -; mRNA.
DR CCDS; CCDS50395.1; -. [Q99N08-1]
DR RefSeq; NP_001159848.1; NM_001166376.1.
DR RefSeq; NP_082871.2; NM_028595.4. [Q99N08-1]
DR AlphaFoldDB; Q99N08; -.
DR SMR; Q99N08; -.
DR STRING; 10090.ENSMUSP00000132425; -.
DR MaxQB; Q99N08; -.
DR PaxDb; Q99N08; -.
DR PRIDE; Q99N08; -.
DR ProteomicsDB; 295756; -. [Q99N08-1]
DR ProteomicsDB; 295757; -. [Q99N08-2]
DR DNASU; 73656; -.
DR Ensembl; ENSMUST00000165310; ENSMUSP00000132425; ENSMUSG00000079419. [Q99N08-1]
DR GeneID; 73656; -.
DR KEGG; mmu:73656; -.
DR UCSC; uc008gsh.2; mouse. [Q99N08-1]
DR CTD; 73656; -.
DR MGI; MGI:2385644; Ms4a6c.
DR VEuPathDB; HostDB:ENSMUSG00000079419; -.
DR eggNOG; ENOG502SUQB; Eukaryota.
DR GeneTree; ENSGT00940000162688; -.
DR HOGENOM; CLU_089673_1_0_1; -.
DR InParanoid; Q99N08; -.
DR OMA; HHYYHIS; -.
DR OrthoDB; 1275704at2759; -.
DR PhylomeDB; Q99N08; -.
DR TreeFam; TF335157; -.
DR BioGRID-ORCS; 73656; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Ms4a6c; mouse.
DR PRO; PR:Q99N08; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q99N08; protein.
DR Bgee; ENSMUSG00000079419; Expressed in stroma of bone marrow and 122 other tissues.
DR Genevisible; Q99N08; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; ISO:MGI.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR030417; MS4A.
DR InterPro; IPR030427; MS4A6A-E.
DR PANTHER; PTHR23320; PTHR23320; 1.
DR PANTHER; PTHR23320:SF120; PTHR23320:SF120; 1.
DR Pfam; PF04103; CD20; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Receptor; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..217
FT /note="Membrane-spanning 4-domains subfamily A member 6C"
FT /id="PRO_0000158640"
FT TOPO_DOM 1..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..84
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..186
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..217
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 95..119
FT /note="FIASGILSIITERKSTKPLVDASLT -> VSRLLGGIKWGKTEKGVFTQLHF
FT CI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_007385"
FT VAR_SEQ 120..217
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_007386"
FT CONFLICT 13
FT /note="T -> K (in Ref. 2; BAB25808)"
FT /evidence="ECO:0000305"
FT CONFLICT 36
FT /note="S -> C (in Ref. 2; BAB25808)"
FT /evidence="ECO:0000305"
FT CONFLICT 40
FT /note="H -> L (in Ref. 2; BAB25808)"
FT /evidence="ECO:0000305"
FT CONFLICT 69
FT /note="V -> G (in Ref. 2; BAB25808)"
FT /evidence="ECO:0000305"
FT CONFLICT 112
FT /note="P -> L (in Ref. 2; BAB25808)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="A -> V (in Ref. 2; BAB25808)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 217 AA; 23622 MW; 8BF521AF22DBB7BD CRC64;
MIPQVVTNET ITTISPNGIN FPQKDESQPT QQRQDSLKKH LKAEIKVIVA IQIMCAVTVL
ALGIILASVP PVPYFNSVFS VLLKSGYPFI GALFFIASGI LSIITERKST KPLVDASLTL
NILSVSFAFV GIIIISVSLA GLHPASEQCK QSKELSLIEH DYYQPFYNSD RSECAVTKSI
LTGALSVMLI ISVLELGLAL LSAMLWLREG VLTSLRM
