M4A6D_MOUSE
ID M4A6D_MOUSE Reviewed; 247 AA.
AC Q99N07; Q9D0X1; Q9EQY7;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Membrane-spanning 4-domains subfamily A member 6D;
DE AltName: Full=CD20 antigen-like 8;
GN Name=Ms4a6d; Synonyms=Cd20l8, Ms4a11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mammary gland;
RX PubMed=11401424; DOI=10.1006/geno.2000.6472;
RA Liang Y., Tedder T.F.;
RT "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene
RT family: sixteen new MS4A family members expressed in human and mouse.";
RL Genomics 72:119-127(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-189.
RX PubMed=11245982; DOI=10.1016/s0378-1119(00)00598-9;
RA Ishibashi K., Suzuki M., Sasaki S., Imai M.;
RT "Identification of a new multigene four-transmembrane family (MS4A) related
RT to CD20, HTm4 and beta subunit of the high-affinity IgE receptor.";
RL Gene 264:87-93(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in signal transduction as a component of a
CC multimeric receptor complex.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in thymus, spleen, intestine, colon,
CC testis, heart, liver, brain, kidney, peripheral lymph node and bone
CC marrow.
CC -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB18759.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF237911; AAK37593.1; -; mRNA.
DR EMBL; AB026047; BAB18759.1; ALT_FRAME; mRNA.
DR EMBL; AK004295; BAB23253.1; -; mRNA.
DR EMBL; BC018331; AAH18331.1; -; mRNA.
DR EMBL; BC029738; AAH29738.1; -; mRNA.
DR CCDS; CCDS29603.1; -.
DR RefSeq; NP_081111.1; NM_026835.2.
DR AlphaFoldDB; Q99N07; -.
DR SMR; Q99N07; -.
DR BioGRID; 213043; 1.
DR STRING; 10090.ENSMUSP00000025582; -.
DR iPTMnet; Q99N07; -.
DR PhosphoSitePlus; Q99N07; -.
DR PaxDb; Q99N07; -.
DR PRIDE; Q99N07; -.
DR ProteomicsDB; 287284; -.
DR DNASU; 68774; -.
DR GeneID; 68774; -.
DR KEGG; mmu:68774; -.
DR CTD; 68774; -.
DR MGI; MGI:1916024; Ms4a6d.
DR eggNOG; ENOG502SUQB; Eukaryota.
DR InParanoid; Q99N07; -.
DR OrthoDB; 1275704at2759; -.
DR PhylomeDB; Q99N07; -.
DR BioGRID-ORCS; 68774; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q99N07; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q99N07; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; ISO:MGI.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR030417; MS4A.
DR InterPro; IPR030427; MS4A6A-E.
DR PANTHER; PTHR23320; PTHR23320; 1.
DR PANTHER; PTHR23320:SF120; PTHR23320:SF120; 1.
DR Pfam; PF04103; CD20; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..247
FT /note="Membrane-spanning 4-domains subfamily A member 6D"
FT /id="PRO_0000158641"
FT TOPO_DOM 1..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..180
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..247
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 235
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 61
FT /note="S -> A (in Ref. 3; BAB23253 and 4; AAH29738)"
FT /evidence="ECO:0000305"
FT CONFLICT 69
FT /note="V -> G (in Ref. 2; BAB18759)"
FT /evidence="ECO:0000305"
FT CONFLICT 79
FT /note="F -> V (in Ref. 2; BAB18759)"
FT /evidence="ECO:0000305"
FT CONFLICT 94
FT /note="F -> V (in Ref. 2; BAB18759)"
FT /evidence="ECO:0000305"
FT CONFLICT 102..104
FT /note="SIV -> AIG (in Ref. 2; BAB18759)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="V -> G (in Ref. 2; BAB18759)"
FT /evidence="ECO:0000305"
FT CONFLICT 124
FT /note="S -> R (in Ref. 2; BAB18759)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="S -> R (in Ref. 2; BAB18759)"
FT /evidence="ECO:0000305"
FT CONFLICT 149
FT /note="C -> W (in Ref. 2; BAB18759)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="H -> Q (in Ref. 2; BAB18759)"
FT /evidence="ECO:0000305"
FT CONFLICT 180
FT /note="Missing (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 247 AA; 26383 MW; 18D6E4BD62C7ADA5 CRC64;
MIPQVVTSET VTVISPNGIS FPQTDKPQPS HQSQDSLKKH LKAEIKVMAA IQIMCAVMVL
SLGIILASVP SNLHFTSVFS ILLESGYPFV GALFFAISGI LSIVTEKKMT KPLVHSSLAL
SILSVLSALT GIAILSVSLA ALEPALQQCK LAFTQLDTTQ DAYHFFSPEP LNSCFVAKAA
LTGVFSLMLI SSVLELGLAV LTATLWWKQS SSAFSGNVIF LSQNSKNKSS VSSESLCNPT
YENILTS
