ID   M4A6E_HUMAN             Reviewed;         147 AA.
AC   Q96DS6; Q3MIL2; Q8NE56; Q96PG4; Q96PG5;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Membrane-spanning 4-domains subfamily A member 6E;
GN   Name=MS4A6E;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT PHE-47.
RX   PubMed=11486273; DOI=10.1007/s002510100339;
RA   Liang Y., Buckley T.R., Tu L., Langdon S.D., Tedder T.F.;
RT   "Structural organization of the human MS4A gene cluster on chromosome
RT   11q12.";
RL   Immunogenetics 53:357-368(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in signal transduction as a component of a
CC       multimeric receptor complex.
CC   -!- INTERACTION:
CC       Q96DS6; P29033: GJB2; NbExp=3; IntAct=EBI-17931225, EBI-3905204;
CC       Q96DS6; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-17931225, EBI-988826;
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed by malignant and fetal tissue at very low
CC       levels.
CC   -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR   EMBL; AF354931; AAL07358.1; -; mRNA.
DR   EMBL; AF354932; AAL07359.1; -; mRNA.
DR   EMBL; AF354933; AAL07360.1; -; mRNA.
DR   EMBL; AF333758; AAQ14868.1; -; mRNA.
DR   EMBL; BC034588; AAH34588.1; -; mRNA.
DR   EMBL; BC069322; AAH69322.1; -; mRNA.
DR   EMBL; BC101783; AAI01784.1; -; mRNA.
DR   CCDS; CCDS7984.1; -.
DR   RefSeq; NP_640342.1; NM_139249.2.
DR   AlphaFoldDB; Q96DS6; -.
DR   BioGRID; 128829; 8.
DR   IntAct; Q96DS6; 2.
DR   STRING; 9606.ENSP00000300182; -.
DR   BioMuta; MS4A6E; -.
DR   MassIVE; Q96DS6; -.
DR   PaxDb; Q96DS6; -.
DR   PeptideAtlas; Q96DS6; -.
DR   PRIDE; Q96DS6; -.
DR   Antibodypedia; 70842; 49 antibodies from 11 providers.
DR   DNASU; 245802; -.
DR   Ensembl; ENST00000300182.8; ENSP00000300182.4; ENSG00000166926.9.
DR   Ensembl; ENST00000684409.1; ENSP00000507799.1; ENSG00000166926.9.
DR   GeneID; 245802; -.
DR   KEGG; hsa:245802; -.
DR   MANE-Select; ENST00000684409.1; ENSP00000507799.1; NM_139249.4; NP_640342.1.
DR   UCSC; uc001npd.4; human.
DR   CTD; 245802; -.
DR   DisGeNET; 245802; -.
DR   GeneCards; MS4A6E; -.
DR   HGNC; HGNC:14285; MS4A6E.
DR   HPA; ENSG00000166926; Tissue enriched (testis).
DR   MIM; 608402; gene.
DR   neXtProt; NX_Q96DS6; -.
DR   OpenTargets; ENSG00000166926; -.
DR   PharmGKB; PA31123; -.
DR   VEuPathDB; HostDB:ENSG00000166926; -.
DR   eggNOG; ENOG502SUQB; Eukaryota.
DR   GeneTree; ENSGT00940000163439; -.
DR   InParanoid; Q96DS6; -.
DR   OMA; PMTHENI; -.
DR   OrthoDB; 1275704at2759; -.
DR   PhylomeDB; Q96DS6; -.
DR   PathwayCommons; Q96DS6; -.
DR   SignaLink; Q96DS6; -.
DR   BioGRID-ORCS; 245802; 7 hits in 1030 CRISPR screens.
DR   GenomeRNAi; 245802; -.
DR   Pharos; Q96DS6; Tdark.
DR   PRO; PR:Q96DS6; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q96DS6; protein.
DR   Bgee; ENSG00000166926; Expressed in left testis and 92 other tissues.
DR   ExpressionAtlas; Q96DS6; baseline and differential.
DR   Genevisible; Q96DS6; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR007237; CD20-like.
DR   InterPro; IPR030417; MS4A.
DR   InterPro; IPR030427; MS4A6A-E.
DR   PANTHER; PTHR23320; PTHR23320; 2.
DR   PANTHER; PTHR23320:SF135; PTHR23320:SF135; 2.
DR   Pfam; PF04103; CD20; 1.
PE   1: Evidence at protein level;
KW   Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..147
FT                   /note="Membrane-spanning 4-domains subfamily A member 6E"
FT                   /id="PRO_0000158642"
FT   TOPO_DOM        1..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..120
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..147
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   VARIANT         6
FT                   /note="I -> V (in dbSNP:rs2304935)"
FT                   /id="VAR_053518"
FT   VARIANT         10
FT                   /note="T -> A (in dbSNP:rs2304934)"
FT                   /id="VAR_053519"
FT   VARIANT         47
FT                   /note="V -> F (in dbSNP:rs2304933)"
FT                   /evidence="ECO:0000269|PubMed:11486273"
FT                   /id="VAR_015654"
SQ   SEQUENCE   147 AA;  15909 MW;  E273A9B19B4D6DDB CRC64;
     MTSQPISNET IIMLPSNVIN FSQAEKPEPT NQGQDSLKKR LQAKVKVIGV HSSLAGSILS
     ALSALVGFIL LSVNPAALNP ASLQCKLDEK DIPTRLLLSY DYHSPYTMDC HRAKASLAGT
     LSLMLVSTVL EFCLAVLTAV LQWKQTV