M4A8_HUMAN
ID M4A8_HUMAN Reviewed; 250 AA.
AC Q9BY19; Q8TCA5;
DT 04-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Membrane-spanning 4-domains subfamily A member 8;
DE AltName: Full=Four-span transmembrane protein 4;
DE AltName: Full=Membrane-spanning 4-domains subfamily A member 8B;
GN Name=MS4A8; Synonyms=4SPAN4, MS4A8B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=11401424; DOI=10.1006/geno.2000.6472;
RA Liang Y., Tedder T.F.;
RT "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene
RT family: sixteen new MS4A family members expressed in human and mouse.";
RL Genomics 72:119-127(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RA Hulett M.D., Pagler E., Hogarth P.M., Eyre H.J., Baker E., Crawford J.,
RA Sutherland G.R., Parish C.R.;
RT "Isolation of a family of hematopoietic-expressed four-transmembrane genes
RT related to CD20 and Fc-epsilon-RI-beta.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in signal transduction as a component of a
CC multimeric receptor complex.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed by hematopoietic tissues and cells lines.
CC -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR EMBL; AF237905; AAK37414.1; -; mRNA.
DR EMBL; AF350504; AAL56224.1; -; mRNA.
DR EMBL; BC022895; AAH22895.1; -; mRNA.
DR CCDS; CCDS7990.1; -.
DR RefSeq; NP_113645.1; NM_031457.1.
DR AlphaFoldDB; Q9BY19; -.
DR SMR; Q9BY19; -.
DR IntAct; Q9BY19; 1.
DR STRING; 9606.ENSP00000300226; -.
DR iPTMnet; Q9BY19; -.
DR PhosphoSitePlus; Q9BY19; -.
DR BioMuta; MS4A8; -.
DR DMDM; 29611827; -.
DR MassIVE; Q9BY19; -.
DR PaxDb; Q9BY19; -.
DR PeptideAtlas; Q9BY19; -.
DR PRIDE; Q9BY19; -.
DR Antibodypedia; 1542; 144 antibodies from 17 providers.
DR DNASU; 83661; -.
DR Ensembl; ENST00000300226.7; ENSP00000300226.2; ENSG00000166959.8.
DR GeneID; 83661; -.
DR KEGG; hsa:83661; -.
DR MANE-Select; ENST00000300226.7; ENSP00000300226.2; NM_031457.2; NP_113645.1.
DR UCSC; uc001npv.4; human.
DR CTD; 83661; -.
DR DisGeNET; 83661; -.
DR GeneCards; MS4A8; -.
DR HGNC; HGNC:13380; MS4A8.
DR HPA; ENSG00000166959; Tissue enhanced (fallopian tube, intestine).
DR MIM; 606549; gene.
DR neXtProt; NX_Q9BY19; -.
DR OpenTargets; ENSG00000166959; -.
DR PharmGKB; PA31126; -.
DR VEuPathDB; HostDB:ENSG00000166959; -.
DR eggNOG; ENOG502SR7E; Eukaryota.
DR GeneTree; ENSGT00940000162329; -.
DR InParanoid; Q9BY19; -.
DR OMA; QLVCCQH; -.
DR OrthoDB; 1256119at2759; -.
DR PhylomeDB; Q9BY19; -.
DR TreeFam; TF335157; -.
DR PathwayCommons; Q9BY19; -.
DR BioGRID-ORCS; 83661; 14 hits in 1057 CRISPR screens.
DR ChiTaRS; MS4A8; human.
DR GenomeRNAi; 83661; -.
DR Pharos; Q9BY19; Tdark.
DR PRO; PR:Q9BY19; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9BY19; protein.
DR Bgee; ENSG00000166959; Expressed in right uterine tube and 108 other tissues.
DR ExpressionAtlas; Q9BY19; baseline and differential.
DR Genevisible; Q9BY19; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR030417; MS4A.
DR InterPro; IPR030424; MS4A8.
DR PANTHER; PTHR23320; PTHR23320; 1.
DR PANTHER; PTHR23320:SF128; PTHR23320:SF128; 1.
DR Pfam; PF04103; CD20; 1.
PE 2: Evidence at transcript level;
KW Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..250
FT /note="Membrane-spanning 4-domains subfamily A member 8"
FT /id="PRO_0000158645"
FT TOPO_DOM 1..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..180
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 95
FT /note="V -> L (in dbSNP:rs35956659)"
FT /id="VAR_053523"
FT CONFLICT 83
FT /note="H -> R (in Ref. 3; AAH22895)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 250 AA; 26290 MW; C1176E1FFDBD99B1 CRC64;
MNSMTSAVPV ANSVLVVAPH NGYPVTPGIM SHVPLYPNSQ PQVHLVPGNP PSLVSNVNGQ
PVQKALKEGK TLGAIQIIIG LAHIGLGSIM ATVLVGEYLS ISFYGGFPFW GGLWFIISGS
LSVAAENQPY SYCLLSGSLG LNIVSAICSA VGVILFITDL SIPHPYAYPD YYPYAWGVNP
GMAISGVLLV FCLLEFGIAC ASSHFGCQLV CCQSSNVSVI YPNIYAANPV ITPEPVTSPP
SYSSEIQANK
