ID   M4GDA_DANRE             Reviewed;         216 AA.
AC   B0UXU6; Q7T324;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=MIF4G domain-containing protein A;
GN   Name=mif4gda; ORFNames=si:ch211-260p11.2, zgc:64152;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions in replication-dependent translation of histone
CC       mRNAs which differ from other eukaryotic mRNAs in that they do not end
CC       with a poly-A tail but a stem-loop. May participate in circularizing
CC       those mRNAs specifically enhancing their translation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with eif4g1, eif4g2 and slbp; probably tethered by
CC       SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also
CC       interacts with eif4g1 which is bound to their 5'-end. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MIF4GD family. {ECO:0000305}.
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DR   EMBL; CR387927; CAQ14247.1; -; Genomic_DNA.
DR   EMBL; BC053283; AAH53283.1; -; mRNA.
DR   RefSeq; NP_956678.1; NM_200384.1.
DR   AlphaFoldDB; B0UXU6; -.
DR   SMR; B0UXU6; -.
DR   STRING; 7955.ENSDARP00000015004; -.
DR   PaxDb; B0UXU6; -.
DR   PeptideAtlas; B0UXU6; -.
DR   DNASU; 393355; -.
DR   Ensembl; ENSDART00000167674; ENSDARP00000135400; ENSDARG00000102080.
DR   Ensembl; ENSDART00000168236; ENSDARP00000134032; ENSDARG00000102080.
DR   Ensembl; ENSDART00000181407; ENSDARP00000157298; ENSDARG00000102080.
DR   Ensembl; ENSDART00000182464; ENSDARP00000145562; ENSDARG00000117121.
DR   Ensembl; ENSDART00000187768; ENSDARP00000147145; ENSDARG00000115033.
DR   GeneID; 393355; -.
DR   KEGG; dre:393355; -.
DR   CTD; 393355; -.
DR   ZFIN; ZDB-GENE-040426-1382; mif4gda.
DR   eggNOG; KOG3942; Eukaryota.
DR   GeneTree; ENSGT00940000153432; -.
DR   HOGENOM; CLU_081010_1_0_1; -.
DR   InParanoid; B0UXU6; -.
DR   OMA; RDAGHIC; -.
DR   OrthoDB; 1168859at2759; -.
DR   PhylomeDB; B0UXU6; -.
DR   PRO; PR:B0UXU6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000102080; Expressed in mature ovarian follicle and 24 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008494; F:translation activator activity; IBA:GO_Central.
DR   GO; GO:0006446; P:regulation of translational initiation; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   Pfam; PF02854; MIF4G; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Translation regulation.
FT   CHAIN           1..216
FT                   /note="MIF4G domain-containing protein A"
FT                   /id="PRO_0000337093"
FT   DOMAIN          2..199
FT                   /note="MIF4G"
FT   CONFLICT        129
FT                   /note="G -> R (in Ref. 2; AAH53283)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   216 AA;  24857 MW;  A40DA13B16763C0C CRC64;
     MDSAWTALDM ETQTMLKTAI KDPKTVDLEK LSNAVVEHSL KDLSFCKDAG RMCYAVVQAE
     AQKTASSVFR RNLLNRLQQE FIAREETRKR SMQEWVCVVT FICSIFDYIK VNNSPIAALV
     DPVYDCLFGL AQPDSLMNEE EVDCLVVQLH RVGEQLEQTN SERMNQLFYL LRDGFLLQED
     LSSMTRLLLL EILEFRASGW TLSETAHKYY YSEVAD