ID   M4GDA_XENLA             Reviewed;         223 AA.
AC   A3KND5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=MIF4G domain-containing protein A;
GN   Name=mif4gd-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions in replication-dependent translation of histone
CC       mRNAs which differ from other eukaryotic mRNAs in that they do not end
CC       with a poly-A tail but a stem-loop. May participate in circularizing
CC       those mRNAs specifically enhancing their translation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with eif4g1, eif4g2 and slbp; probably tethered by
CC       SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also
CC       interacts with eif4g1 which is bound to their 5'-end. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MIF4GD family. {ECO:0000305}.
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DR   EMBL; BC133785; AAI33786.1; -; mRNA.
DR   RefSeq; NP_001091421.1; NM_001097952.2.
DR   RefSeq; XP_018089382.1; XM_018233893.1.
DR   RefSeq; XP_018089383.1; XM_018233894.1.
DR   RefSeq; XP_018089384.1; XM_018233895.1.
DR   RefSeq; XP_018089385.1; XM_018233896.1.
DR   AlphaFoldDB; A3KND5; -.
DR   SMR; A3KND5; -.
DR   GeneID; 100049112; -.
DR   KEGG; xla:100049112; -.
DR   CTD; 100049112; -.
DR   Xenbase; XB-GENE-5757663; mif4gd.L.
DR   OMA; TMANTAQ; -.
DR   OrthoDB; 1168859at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 100049112; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   Pfam; PF02854; MIF4G; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Translation regulation.
FT   CHAIN           1..223
FT                   /note="MIF4G domain-containing protein A"
FT                   /id="PRO_0000337094"
FT   DOMAIN          7..206
FT                   /note="MIF4G"
SQ   SEQUENCE   223 AA;  25950 MW;  F95314957DE0EB39 CRC64;
     MADSEEQEDY KMQAFDADIQ NLLKTALKEP GNVDLEKAAN VIADQSLRDT TFSREAGRMC
     YTIIQAESKQ TGRTMFRSSL LNRLQVEYKN RKETRARSLQ EWVCYVGFMC NVFDYLRVNN
     MPMLALVHPV YDCLFDLVQP ESLKREEEVD CLVLQLHRVG EQLEKMNCQR MDDLFSQLRD
     SFLLQGGLSS LTQLLLLEMI EYRAAGWRMT DAAQNYYYSE VSD