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M4H36_BOMMX
ID   M4H36_BOMMX             Reviewed;         139 AA.
AC   Q58T62;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Maximins 4/H3 type 6;
DE   Contains:
DE     RecName: Full=Maximin-4;
DE   Contains:
DE     RecName: Full=Maximin-H3;
DE   Flags: Precursor;
OS   Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Bombinatoridae; Bombina.
OX   NCBI_TaxID=161274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT ASN-70 AND ILE-138.
RC   TISSUE=Skin;
RX   PubMed=15770703; DOI=10.1002/eji.200425615;
RA   Lee W.-H., Li Y., Lai R., Li S., Zhang Y., Wang W.;
RT   "Variety of antimicrobial peptides in the Bombina maxima toad and evidence
RT   of their rapid diversification.";
RL   Eur. J. Immunol. 35:1220-1229(2005).
RN   [2]
RP   PROTEIN SEQUENCE OF 44-70, FUNCTION OF MAXIMIN-4, SUBCELLULAR LOCATION, AND
RP   TISSUE SPECIFICITY.
RC   TISSUE=Skin secretion;
RA   Chen T.B., McClean S., Orr D.F., Bjourson A.J., Rao P.F., Shaw C.;
RT   "Isolation and structural characterisation of antimicrobial peptides from
RT   the venom of the Chinese large-webbed bell toad (Bombina maxima).";
RL   Submitted (JUL-2001) to UniProtKB.
RN   [3]
RP   PROTEIN SEQUENCE OF 44-70 AND 119-138, AMIDATION AT ASN-70 AND ILE-138,
RP   FUNCTION OF MAXIMIN-4 AND MAXIMIN-H3, AND MASS SPECTROMETRY.
RC   TISSUE=Skin, and Skin secretion;
RX   PubMed=11835991; DOI=10.1016/s0196-9781(01)00641-6;
RA   Lai R., Zheng Y.-T., Shen J.-H., Liu G.-J., Liu H., Lee W.-H., Tang S.-Z.,
RA   Zhang Y.;
RT   "Antimicrobial peptides from skin secretions of Chinese red belly toad
RT   Bombina maxima.";
RL   Peptides 23:427-435(2002).
CC   -!- FUNCTION: Maximin-4 shows antibacterial activity against both Gram-
CC       positive and Gram-negative bacteria. It shows also antimicrobial
CC       activity against the fungus C.albicans, but not against A.flavus nor
CC       P.uticale. It has little hemolytic activity. It does not possess a
CC       significant cytotoxicity against tumor cell lines. It does not possess
CC       a significant anti-HIV activity.
CC   -!- FUNCTION: Maximin-H3 shows antibacterial activity against both Gram-
CC       positive and Gram-negative bacteria. It shows also antimicrobial
CC       activity against the fungus C.albicans. Shows strong hemolytic
CC       activity.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.2}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands. {ECO:0000269|Ref.2}.
CC   -!- MASS SPECTROMETRY: [Maximin-4]: Mass=2612; Method=FAB;
CC       Evidence={ECO:0000269|PubMed:11835991};
CC   -!- MASS SPECTROMETRY: [Maximin-H3]: Mass=1944; Method=FAB;
CC       Evidence={ECO:0000269|PubMed:11835991};
CC   -!- SIMILARITY: Belongs to the bombinin family. {ECO:0000305}.
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DR   EMBL; AY848998; AAX50219.1; -; mRNA.
DR   EMBL; AY848984; AAX50205.1; -; mRNA.
DR   AlphaFoldDB; Q58T62; -.
DR   SMR; Q58T62; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR007962; Bombinin.
DR   Pfam; PF05298; Bombinin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Cleavage on pair of basic residues; Cytolysis; Direct protein sequencing;
KW   Fungicide; Hemolysis; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..43
FT                   /id="PRO_0000003172"
FT   PEPTIDE         44..70
FT                   /note="Maximin-4"
FT                   /id="PRO_0000003173"
FT   PROPEP          74..118
FT                   /evidence="ECO:0000269|PubMed:11835991"
FT                   /id="PRO_0000003174"
FT   PEPTIDE         119..138
FT                   /note="Maximin-H3"
FT                   /id="PRO_0000003175"
FT   MOD_RES         70
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:11835991,
FT                   ECO:0000269|PubMed:15770703"
FT   MOD_RES         138
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:11835991,
FT                   ECO:0000269|PubMed:15770703"
SQ   SEQUENCE   139 AA;  15222 MW;  C9B13DED74C0C18C CRC64;
     MNFKYIVAVS FLIASAYARS VQNDEQSLSQ RDVLEEESLR EIRGIGGVLL SAGKAALKGL
     AKVLAEKYAN GKRTAEDHEV MKRLEAVMRD LDSLDHPEEA SERETRGFNQ DEIAKEKRIL
     GPVLGLVGNA LGGLIKKIG
 
 
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