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M5_STRP5
ID   M5_STRP5                Reviewed;         492 AA.
AC   P02977;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=M protein, serotype 5;
DE   Flags: Precursor;
GN   Name=emm5; Synonyms=smp5;
OS   Streptococcus pyogenes serotype M5.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301449;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3281944; DOI=10.1016/s0021-9258(18)60617-9;
RA   Miller L., Gray L., Beachey E., Kehoe M.;
RT   "Antigenic variation among group A streptococcal M proteins. Nucleotide
RT   sequence of the serotype 5 M protein gene and its relationship with genes
RT   encoding types 6 and 24 M proteins.";
RL   J. Biol. Chem. 263:5668-5673(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-89.
RX   PubMed=7891551; DOI=10.1111/j.1365-2958.1994.tb01301.x;
RA   Whatmore A.M., Kapur V., Sullivan D.J., Musser J.M., Kehoe M.A.;
RT   "Non-congruent relationships between variation in emm gene sequences and
RT   the population genetic structure of group A streptococci.";
RL   Mol. Microbiol. 14:619-631(1994).
RN   [3]
RP   PROTEIN SEQUENCE OF 43-212 AND 238-250.
RX   PubMed=6368549; DOI=10.1016/s0021-9258(17)43150-4;
RA   Manjula B.N., Acharya A.S., Mische S.M., Fairwell T., Fischetti V.A.;
RT   "The complete amino acid sequence of a biologically active 197-residue
RT   fragment of M protein isolated from type 5 group A streptococci.";
RL   J. Biol. Chem. 259:3686-3693(1984).
CC   -!- FUNCTION: This protein is one of the different antigenic serotypes of
CC       protein M. Protein M is closely associated with virulence of the
CC       bacterium and can render the organism resistant to phagocytosis.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}.
CC   -!- SIMILARITY: Belongs to the M protein family. {ECO:0000305}.
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DR   EMBL; M20374; AAA26976.1; -; Genomic_DNA.
DR   PIR; A03501; MMSOMP.
DR   PIR; A28616; A28616.
DR   PDB; 2KK9; NMR; -; A=300-354.
DR   PDBsum; 2KK9; -.
DR   AlphaFoldDB; P02977; -.
DR   SMR; P02977; -.
DR   EvolutionaryTrace; P02977; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR019950; M_anchor.
DR   InterPro; IPR003345; M_repeat.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF02370; M; 2.
DR   PRINTS; PR00015; GPOSANCHOR.
DR   TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell wall; Coiled coil; Direct protein sequencing;
KW   Peptidoglycan-anchor; Phagocytosis; Repeat; Secreted; Signal; Virulence.
FT   SIGNAL          1..42
FT                   /evidence="ECO:0000269|PubMed:6368549"
FT   CHAIN           43..461
FT                   /note="M protein, serotype 5"
FT                   /id="PRO_0000005615"
FT   PROPEP          462..492
FT                   /note="Removed by sortase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT                   /id="PRO_0000005616"
FT   REPEAT          69..75
FT                   /note="1"
FT   REPEAT          76..82
FT                   /note="2"
FT   REPEAT          83..89
FT                   /note="3"
FT   REPEAT          90..96
FT                   /note="4"
FT   REPEAT          97..103
FT                   /note="5"
FT   REGION          69..103
FT                   /note="5 X 7 AA tandem repeats of L-K-T-K-N-E-G"
FT   REGION          71..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          235..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           458..462
FT                   /note="LPXTG sorting signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   COMPBIAS        71..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..354
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..464
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         461
FT                   /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   CONFLICT        43
FT                   /note="A -> T (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        50
FT                   /note="N -> S (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        102
FT                   /note="K -> SNLERKTAELTSEK (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        208
FT                   /note="I -> L (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   STRAND          304..307
FT                   /evidence="ECO:0007829|PDB:2KK9"
FT   HELIX           311..332
FT                   /evidence="ECO:0007829|PDB:2KK9"
FT   STRAND          334..340
FT                   /evidence="ECO:0007829|PDB:2KK9"
FT   STRAND          343..345
FT                   /evidence="ECO:0007829|PDB:2KK9"
FT   TURN            346..349
FT                   /evidence="ECO:0007829|PDB:2KK9"
SQ   SEQUENCE   492 AA;  55085 MW;  873779B6CBD55E27 CRC64;
     MARENTNKHY WLRKLKKGTA SVAVALSVLG AGLVVNTNEV SAAVTRGTIN DPQRAKEALD
     KYELENHDLK TKNEGLKTEN EGLKTENEGL KTENEGLKTE KKEHEAENDK LKQQRDTLST
     QKETLEREVQ NTQYNNETLK IKNGDLTKEL NKTRQELANK QQESKENEKA LNELLEKTVK
     DKIAKEQENK ETIGTLKKIL DETVKDKIAK EQENKETIGT LKKILDETVK DKLAKEQKSK
     QNIGALKQEL AKKDEANKIS DASRKGLRRD LDASREAKKQ LEAEHQKLEE QNKISEASRK
     GLRRDLDASR EAKKQLEAEQ QKLEEQNKIS EASRKGLRRD LDASREAKKQ VEKALEEANS
     KLAALEKLNK ELEESKKLTE KEKAELQAKL EAEAKALKEQ LAKQAEELAK LRAGKASDSQ
     TPDTKPGNKA VPGKGQAPQA GTKPNQNKAP MKETKRQLPS TGETANPFFT AAALTVMATA
     GVAAVVKRKE EN
 
 
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