ID   M63_CONIM               Reviewed;          81 AA.
AC   B6V6L0;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Conotoxin Im6.1;
DE   AltName: Full=Conotoxin 3;
DE   Flags: Precursor;
OS   Conus imperialis (Imperial cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=35631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RA   Liu Z., Dai Q.;
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   EMBL; FJ237364; ACI96055.1; -; mRNA.
DR   AlphaFoldDB; B6V6L0; -.
DR   ConoServer; 3400; Im6.7 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..47
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000392726"
FT   PEPTIDE         48..81
FT                   /note="Conotoxin Im6.1"
FT                   /id="PRO_0000392727"
FT   DISULFID        49..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..67
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..76
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   81 AA;  9078 MW;  28459FE1C53D5F7C CRC64;
     MSKLGVVLFT LLLLVPLVTP ERDGGKWTML AKNKKAMKRN LMDFITRTCD PYYCNDGKVC
     CPEYPTCGDS TGKLICVRVT D