MA7D2_MOUSE
ID MA7D2_MOUSE Reviewed; 781 AA.
AC A2AG50; A2AG54; Q8BLE6; Q8BMQ4; Q9D2A4;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=MAP7 domain-containing protein 2;
GN Name=Map7d2; Synonyms=Mtap7d2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A2AG50-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2AG50-2; Sequence=VSP_028494, VSP_028495;
CC Name=3;
CC IsoId=A2AG50-3; Sequence=VSP_028494, VSP_028495, VSP_028496,
CC VSP_028497;
CC -!- SIMILARITY: Belongs to the MAP7 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC26896.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK019929; BAB31923.1; -; mRNA.
DR EMBL; AK030316; BAC26896.1; ALT_FRAME; mRNA.
DR EMBL; AK045412; BAC32351.1; -; mRNA.
DR EMBL; AL672284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS41193.1; -. [A2AG50-1]
DR CCDS; CCDS85823.1; -. [A2AG50-3]
DR CCDS; CCDS85824.1; -. [A2AG50-2]
DR RefSeq; NP_001074593.1; NM_001081124.2. [A2AG50-1]
DR RefSeq; NP_001300680.1; NM_001313751.1.
DR RefSeq; NP_001300681.1; NM_001313752.1. [A2AG50-3]
DR RefSeq; NP_001300682.1; NM_001313753.1. [A2AG50-2]
DR AlphaFoldDB; A2AG50; -.
DR SMR; A2AG50; -.
DR BioGRID; 219302; 2.
DR STRING; 10090.ENSMUSP00000108090; -.
DR iPTMnet; A2AG50; -.
DR PhosphoSitePlus; A2AG50; -.
DR jPOST; A2AG50; -.
DR MaxQB; A2AG50; -.
DR PaxDb; A2AG50; -.
DR PeptideAtlas; A2AG50; -.
DR PRIDE; A2AG50; -.
DR ProteomicsDB; 292142; -. [A2AG50-1]
DR ProteomicsDB; 292143; -. [A2AG50-2]
DR ProteomicsDB; 292144; -. [A2AG50-3]
DR Antibodypedia; 63281; 17 antibodies from 8 providers.
DR DNASU; 78283; -.
DR Ensembl; ENSMUST00000043151; ENSMUSP00000046693; ENSMUSG00000041020. [A2AG50-2]
DR Ensembl; ENSMUST00000112470; ENSMUSP00000108089; ENSMUSG00000041020. [A2AG50-3]
DR Ensembl; ENSMUST00000112471; ENSMUSP00000108090; ENSMUSG00000041020. [A2AG50-1]
DR GeneID; 78283; -.
DR KEGG; mmu:78283; -.
DR UCSC; uc009usn.1; mouse. [A2AG50-1]
DR UCSC; uc009uso.1; mouse. [A2AG50-2]
DR UCSC; uc009usp.1; mouse. [A2AG50-3]
DR CTD; 256714; -.
DR MGI; MGI:1917474; Map7d2.
DR VEuPathDB; HostDB:ENSMUSG00000041020; -.
DR eggNOG; ENOG502QTSG; Eukaryota.
DR GeneTree; ENSGT00950000182941; -.
DR HOGENOM; CLU_017315_1_0_1; -.
DR InParanoid; A2AG50; -.
DR OMA; LNTCQEI; -.
DR OrthoDB; 265189at2759; -.
DR PhylomeDB; A2AG50; -.
DR TreeFam; TF332273; -.
DR BioGRID-ORCS; 78283; 0 hits in 73 CRISPR screens.
DR PRO; PR:A2AG50; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; A2AG50; protein.
DR Bgee; ENSMUSG00000041020; Expressed in pontine nuclear group and 161 other tissues.
DR ExpressionAtlas; A2AG50; baseline and differential.
DR Genevisible; A2AG50; MM.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR InterPro; IPR008604; MAP7_fam.
DR Pfam; PF05672; MAP7; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..781
FT /note="MAP7 domain-containing protein 2"
FT /id="PRO_0000306810"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 73..168
FT /evidence="ECO:0000255"
FT COMPBIAS 69..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..151
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028494"
FT VAR_SEQ 182..214
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028495"
FT VAR_SEQ 480
FT /note="L -> M (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028496"
FT VAR_SEQ 481..781
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028497"
SQ SEQUENCE 781 AA; 86050 MW; 06BBD409721DE9B1 CRC64;
MERSGGNGGG GGGGGGGGGG YGGSGGGGGG AGVPSEGAAK GLSLLLAKSA EAASGRASQS
TPRSAGMDGF LKSDERQRLA KERREEREKC LAAREQQILE KQKRAKLQYE KQIEERWRKL
EEQRQREDQK RAAVEEKRKQ KLREEEERLE AMMRRSLERT QQLELKKKCS WAGSPGPGGR
DGESENTPPL PLTLATSTPP LDTGTTTAAA ESTNACDKLS TSTMNLPKQT ESPMSKHLSS
STVAISYSPD RALGSPLKSS YKSSPTRTTE KKKNTPISAM GDAGKGAMAG GEPSQMEKMK
KGRVATSAAS GGHGSPLRRC EPPEDISKRL SSPVKSKITS KTYPQSPKTA KPTYLGSPVK
YYFPPIANEE TPKKKAEKEK RNKEKEGAPG QQSTVLPREE SLEKRMADKY ATEKYVADKH
ATEKHSAPGG KAEHSAGKPT AGTTDAGEAA KILAEKRRQA RLQKEQEEQE RLEKEERERL
EKEELKRKAE EERLRIEMAY KREQEKKRQE EEEKRKAEEK AKEKAEEELL SKEKQEKEKQ
EQEKKEKAMI EKQKEAAEAK AQDAAKQMRL EREQIMLQIE QERLERKKRI DEIMKRTRKS
DASLEVKKED PKVELQPPPD VENKANKAKP VVPNKIEINV LNTCQKVSGS ERAAPETFPQ
DIFSTGLKPV GGPVHLDVLD GKSNSLDDST EDVQSMDVSP VSKEELISIP EFSPVSEMIP
GMSLDQNGTG NARALQDILD FTGPPAFPKK SSENLSLDDC NKNLIEGFNS PGQETTLNTF
C
