ID   MAAI_PSEAE              Reviewed;         212 AA.
AC   P57109;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Maleylacetoacetate isomerase;
DE            Short=MAAI;
DE            EC=5.2.1.2;
GN   Name=maiA; OrderedLocusNames=PA2007;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-maleylacetoacetate = 4-fumarylacetoacetate;
CC         Xref=Rhea:RHEA:14817, ChEBI:CHEBI:17105, ChEBI:CHEBI:18034;
CC         EC=5.2.1.2;
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetate and fumarate from L-phenylalanine: step 5/6.
CC   -!- SIMILARITY: Belongs to the GST superfamily. Zeta family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE004091; AAG05395.1; -; Genomic_DNA.
DR   PIR; D83394; D83394.
DR   RefSeq; NP_250697.1; NC_002516.2.
DR   RefSeq; WP_003113505.1; NZ_QZGE01000026.1.
DR   AlphaFoldDB; P57109; -.
DR   SMR; P57109; -.
DR   STRING; 287.DR97_5841; -.
DR   PaxDb; P57109; -.
DR   PRIDE; P57109; -.
DR   EnsemblBacteria; AAG05395; AAG05395; PA2007.
DR   GeneID; 879853; -.
DR   KEGG; pae:PA2007; -.
DR   PATRIC; fig|208964.12.peg.2091; -.
DR   PseudoCAP; PA2007; -.
DR   HOGENOM; CLU_011226_20_1_6; -.
DR   InParanoid; P57109; -.
DR   OMA; CCQRIII; -.
DR   PhylomeDB; P57109; -.
DR   BioCyc; PAER208964:G1FZ6-2045-MON; -.
DR   UniPathway; UPA00139; UER00340.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
DR   GO; GO:0016034; F:maleylacetoacetate isomerase activity; IBA:GO_Central.
DR   GO; GO:0006749; P:glutathione metabolic process; IBA:GO_Central.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IBA:GO_Central.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd03191; GST_C_Zeta; 1.
DR   CDD; cd03042; GST_N_Zeta; 1.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR005955; GST_Zeta.
DR   InterPro; IPR034330; GST_Zeta_C.
DR   InterPro; IPR034333; GST_Zeta_N.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF13417; GST_N_3; 1.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR01262; maiA; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   3: Inferred from homology;
KW   Isomerase; Phenylalanine catabolism; Reference proteome;
KW   Tyrosine catabolism.
FT   CHAIN           1..212
FT                   /note="Maleylacetoacetate isomerase"
FT                   /id="PRO_0000186035"
FT   DOMAIN          1..83
FT                   /note="GST N-terminal"
FT   DOMAIN          88..211
FT                   /note="GST C-terminal"
SQ   SEQUENCE   212 AA;  23685 MW;  534F21D1680C7F4A CRC64;
     MKLYTYYRST SSYRVRIALA LKGLDYQSLP VNLIRDGGEH RQPAYLALNP QGRVPALQVD
     EGELLIQSPA IIEYLEERYP QPALLSSDPL RRARERGVAA LVGCDIHPLH NASVLNLLRQ
     WGHDEEQVRQ WIGHWVGQGL AAVEQLIGDQ GWCFGDRPGL ADVYLVPQLY AAERFGVALD
     AWPRIRRVAD LAAAHPAFRQ AHPANQPDTP AA