ID   MAAI_VIBCH              Reviewed;         215 AA.
AC   Q9KSB2;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Probable maleylacetoacetate isomerase;
DE            Short=MAAI;
DE            EC=5.2.1.2;
GN   Name=maiA; OrderedLocusNames=VC_1347;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-maleylacetoacetate = 4-fumarylacetoacetate;
CC         Xref=Rhea:RHEA:14817, ChEBI:CHEBI:17105, ChEBI:CHEBI:18034;
CC         EC=5.2.1.2;
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetate and fumarate from L-phenylalanine: step 5/6.
CC   -!- SIMILARITY: Belongs to the GST superfamily. Zeta family. {ECO:0000305}.
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DR   EMBL; AE003852; AAF94505.1; -; Genomic_DNA.
DR   PIR; F82211; F82211.
DR   RefSeq; NP_230991.1; NC_002505.1.
DR   AlphaFoldDB; Q9KSB2; -.
DR   SMR; Q9KSB2; -.
DR   STRING; 243277.VC_1347; -.
DR   DNASU; 2614801; -.
DR   EnsemblBacteria; AAF94505; AAF94505; VC_1347.
DR   KEGG; vch:VC_1347; -.
DR   PATRIC; fig|243277.26.peg.1284; -.
DR   eggNOG; COG0625; Bacteria.
DR   HOGENOM; CLU_011226_20_1_6; -.
DR   OMA; VYNAHRF; -.
DR   BioCyc; VCHO:VC1347-MON; -.
DR   UniPathway; UPA00139; UER00340.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
DR   GO; GO:0016034; F:maleylacetoacetate isomerase activity; IBA:GO_Central.
DR   GO; GO:0006749; P:glutathione metabolic process; IBA:GO_Central.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IBA:GO_Central.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd03191; GST_C_Zeta; 1.
DR   CDD; cd03042; GST_N_Zeta; 1.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR005955; GST_Zeta.
DR   InterPro; IPR034330; GST_Zeta_C.
DR   InterPro; IPR034333; GST_Zeta_N.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF14497; GST_C_3; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR01262; maiA; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   3: Inferred from homology;
KW   Isomerase; Phenylalanine catabolism; Reference proteome;
KW   Tyrosine catabolism.
FT   CHAIN           1..215
FT                   /note="Probable maleylacetoacetate isomerase"
FT                   /id="PRO_0000186037"
FT   DOMAIN          2..85
FT                   /note="GST N-terminal"
FT   DOMAIN          90..215
FT                   /note="GST C-terminal"
SQ   SEQUENCE   215 AA;  24628 MW;  8983C86C4D7F5058 CRC64;
     MMSLILYGYW RSSAAYRVRI ALNIKQLVYE SRAVHLSREG GEQHHAEFHR LNPSELIPVL
     IDGELCLNQS LAIIEYLDET YPAPRLIPER GAERYQVKAL ALDIAADIHP INNLRILQYL
     TAKLGVADEE KNRWYRHWID KGFQGLEEKL RHTAGEYCVG NRLSLVDVCL VPQVYNAERF
     DLDMSRYPTL QQIAARLRAL PAFAQAAPEN QPDAC