ID   MAAY3_SCHCO             Reviewed;         926 AA.
AC   P37934;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Mating-type protein A-alpha Y3;
OS   Schizophyllum commune (Split gill fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX   NCBI_TaxID=5334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=UVM 9-4;
RX   PubMed=1353886; DOI=10.1073/pnas.89.15.7169;
RA   Stankis M.M., Specht C.A., Yang H., Giasson L., Ullrich R.C., Novotny C.P.;
RT   "The A alpha mating locus of Schizophyllum commune encodes two dissimilar
RT   multiallelic homeodomain proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:7169-7173(1992).
CC   -!- FUNCTION: Specifies A-alpha-3 mating-type. May regulate the expression
CC       of genes specific to the homokaryotic cell type.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed constitutively in homokaryons.
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DR   EMBL; M97180; AAB01370.1; -; Genomic_DNA.
DR   PIR; B37271; B37271.
DR   AlphaFoldDB; P37934; -.
DR   SMR; P37934; -.
DR   PRIDE; P37934; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0019953; P:sexual reproduction; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR007689; AalphaY_mating_typ-dep-bd-dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF04611; AalphaY_MDB; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..926
FT                   /note="Mating-type protein A-alpha Y3"
FT                   /id="PRO_0000049188"
FT   DNA_BIND        147..206
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          238..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          308..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          424..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          625..734
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        265..281
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..338
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        427..448
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        631..663
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        666..687
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        697..730
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   926 AA;  101834 MW;  1866317422D3E2E8 CRC64;
     MVDRLKLLQA ISTSAKDLAS FALSRGASPI PQPVGLTDVT FDPLPLPDLN ALHRRLKDAG
     LPPKTTKSAI KAYDEACSRW RSTVDESFKA TASAVSPRNL HLLLSLRHHV YAQQVQKWLW
     QVLQVPELWK AEMAKQRAHI TATMDTYKKP RPKFHSEYTP LLELYFHFNA YPTFADRRML
     AEKTGMQTRQ ITVWFQNHRR RAKGPLPRMA PTDKIPMEEF ERQRENMARK LLPVLLPSHL
     RPAPSGSENA SPARSIPRAT MSAAKSKKPD GDKEALRKVG KKALRDAAKT AKANSSTVLG
     ALVAAGVQQA PEAKNSKKAK KAARKNAQDV EMRDATKSHE KRRKTKAMPR PAGQVPMDVD
     GRAHKKSTKT TSSAFDSKAE LAFARMAYPA PSPYAWVHTA PKSSHVMPSA PFKDAHISDI
     RKLGKGKPSQ NLTSTPATFS TVPPRRTSSR LNAMRPPYAF PATYDSASVP MTFAAAQTLR
     FSFVTDSQAF GFRQRYPLSV GEKVHSGAID ALTRRFESLR VLCAEFSTPK KQTSSFERQT
     LCRLRAEGLK AGEIEVRHLV AADSYAARRA ITYVTPRAPL DSVVVDLPRA LQLRLVKPLV
     PAEPIVRPDD FAPFVALAEK RAKRRARKEK KKQAEKEARK EEKRARKEAK QAKKDRKEQR
     AGLPRRSPST LDSSRASSVT SDASATSRKS RTSRKPRDSS ASSVASARTP SLSSTSSRRS
     SGTSMPATPR MNESLPVVAS DNFVLGTDKD VTMTPELMAQ LFGEDDASGL DEPMQSEGFS
     PDMLIFSSCN DGALGDMTAD VNMPELGDLS DTQLSFDDMN WTSSMDLSTQ PAASFDSSSE
     TSSMDFNWLL PQCANTAPDW SALIGMTPST TSQIHVLGGT YSCELGGTNT TNAPLNFADL
     SFELDAGEDC FINFDHNPLG GTMLAV