ID   MAAY4_SCHCO             Reviewed;         928 AA.
AC   P37935;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Mating-type protein A-alpha Y4;
OS   Schizophyllum commune (Split gill fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX   NCBI_TaxID=5334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 44201 / CBS 340.81 / UVM 4-40 / 4-40;
RX   PubMed=1353886; DOI=10.1073/pnas.89.15.7169;
RA   Stankis M.M., Specht C.A., Yang H., Giasson L., Ullrich R.C., Novotny C.P.;
RT   "The A alpha mating locus of Schizophyllum commune encodes two dissimilar
RT   multiallelic homeodomain proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:7169-7173(1992).
CC   -!- FUNCTION: Specifies A-alpha-4 mating-type. May regulate the expression
CC       of genes specific to the homokaryotic cell type.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed constitutively in homokaryons.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M97181; AAB01373.1; -; Genomic_DNA.
DR   PIR; C37271; C37271.
DR   AlphaFoldDB; P37935; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0019953; P:sexual reproduction; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR007689; AalphaY_mating_typ-dep-bd-dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF04611; AalphaY_MDB; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..928
FT                   /note="Mating-type protein A-alpha Y4"
FT                   /id="PRO_0000049189"
FT   DNA_BIND        152..211
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          255..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          406..451
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          626..736
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..271
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..286
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..424
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        433..450
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        632..658
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        659..682
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        695..728
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   928 AA;  101486 MW;  3171C3ABB42064F6 CRC64;
     MAELLACLQS ISAHAKDMMA LARSRGATGS RPTPTTLPHF DELLPPNLDF VRTRLQEARL
     PPKAIKGTLS AYESACARWK HDLEEAFDRT AHSISPHNFQ RLAQLRTRLY VEQVQKWLYE
     VLQVPERWKA EMEKQRAHIN ATMGPDKTTG PGKRSRPKFH SEYTPVLELY FHFNAYPTYA
     DRRILAEKTG MLTRQITVWF QNHRRRAKGP LPRMSPTAKI PMEEFERQLE NLARKIVPVL
     LPPTLRRFAP GNENKSLAAA SRQSAGKSSK NAKRLSELEK AQQVPRKPSE NAEAGPSSLG
     AMLARVMHND SVSKKKSKKA KKEKASQQNV VCDVEMRDAT ATKEKRRKMK KLPRAAGQPF
     DVPMDVERAD KASRKAMKKA KKSPRAFDSR AELAFAQAAY PSPSQYAYVH SRKPSAQKPS
     SDSPRKDFGQ LGKGRPSSNS TSSTVPPHRV SSRLNAMRPP YAFPAPYNAA AVPLTFSVAS
     STQFAFATDN RSFGFAERTP RKATVPAACT LIDYLISKFA GLRLLCVEQS VSSRSISLST
     SESGKLAGLR TEGLTTGEAS GVQTHVDSYA ARRAITYVPP SAPLDCVVHN LARALQLKQV
     RPMVLAQPVV QPDAFAPFIA RAERRARRKE RKQRKALEEK QAKKDRKERQ KASRSQRDSP
     SMDADVQSRA SSVASTSSLP ARKSSKKSRK SKGESAASSR ATSVASSVRT PSLSSTSSRR
     SSGMSMPGTP RPEQDLPIMA TADFNFAGDE DVTMTPDLAA QLFGEDEDGA AALGQMQYEE
     FSPDMLTFTS TAGGALSDMT ADVNMPDLGN AYTSQQSVDD MNWTGFGLDA QNSASPGLFG
     DESNTGLDWL LSHNLLGDTQ MSDLSYTAPT STPSQINILG STYACELGGS DSLGTPFNMN
     DWTFGLGACD DGFAGFGNNL LGGTAVAV