ID   MAB10_CAEEL             Reviewed;         582 AA.
AC   Q22002;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=NAB transcription cofactor mab-10 {ECO:0000303|PubMed:21862562};
DE   AltName: Full=Protein male abnormal 10 {ECO:0000312|WormBase:R166.1a};
GN   Name=mab-10 {ECO:0000312|WormBase:R166.1a};
GN   ORFNames=R166.1 {ECO:0000312|WormBase:R166.1a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH LIN-29, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP   STAGE, AND MUTAGENESIS OF 153-TYR--SER-582 AND 157-GLN--SER-582.
RX   PubMed=21862562; DOI=10.1242/dev.065417;
RA   Harris D.T., Horvitz H.R.;
RT   "MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and
RT   the transition from larva to adult in C. elegans.";
RL   Development 138:4051-4062(2011).
CC   -!- FUNCTION: Transcriptional cofactor (PubMed:21862562). Heterochronic
CC       protein, involved in timing of a subset of differentiation events
CC       during the larval-to-adult transition (PubMed:21862562). Promotes
CC       hypodermal terminal differentiation, together with transcription factor
CC       lin-29, perhaps as part of a transcriptional complex (PubMed:21862562).
CC       Involved in regulating molting by repressing the expression of nuclear
CC       hormone receptors nhr-23 and nhr-25 in the adult hypoderm, probably
CC       acting in concert with lin-29 (PubMed:21862562).
CC       {ECO:0000269|PubMed:21862562}.
CC   -!- SUBUNIT: Interacts with transcription factor lin-29 (via C-terminus).
CC       {ECO:0000269|PubMed:21862562}.
CC   -!- INTERACTION:
CC       Q22002; G5EC32: sorb-1; NbExp=4; IntAct=EBI-2316177, EBI-325337;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21862562}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in pharyngeal cells throughout
CC       development, vulval precursor cells during the larval L3 stage, and the
CC       seam cells and hypodermal syncytia derived from the seam cell lineages
CC       throughout the larval L4 stage and adulthood.
CC       {ECO:0000269|PubMed:21862562}.
CC   -!- SIMILARITY: Belongs to the NAB family. {ECO:0000305}.
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DR   EMBL; BX284602; CAA90662.2; -; Genomic_DNA.
DR   RefSeq; NP_496268.2; NM_063867.2.
DR   AlphaFoldDB; Q22002; -.
DR   SMR; Q22002; -.
DR   IntAct; Q22002; 7.
DR   STRING; 6239.R166.1; -.
DR   PaxDb; Q22002; -.
DR   EnsemblMetazoa; R166.1a.1; R166.1a.1; WBGene00003107.
DR   EnsemblMetazoa; R166.1a.2; R166.1a.2; WBGene00003107.
DR   GeneID; 187916; -.
DR   KEGG; cel:CELE_R166.1; -.
DR   UCSC; R166.1; c. elegans.
DR   CTD; 187916; -.
DR   WormBase; R166.1a; CE43283; WBGene00003107; mab-10.
DR   eggNOG; KOG3835; Eukaryota.
DR   GeneTree; ENSGT00390000006330; -.
DR   HOGENOM; CLU_475872_0_0_1; -.
DR   InParanoid; Q22002; -.
DR   OMA; TCDEHEF; -.
DR   OrthoDB; 1002244at2759; -.
DR   PhylomeDB; Q22002; -.
DR   Reactome; R-CEL-9031628; NGF-stimulated transcription.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00003107; Expressed in gonad and 26 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IPI:UniProtKB.
DR   GO; GO:0003712; F:transcription coregulator activity; IMP:UniProtKB.
DR   GO; GO:0010458; P:exit from mitosis; IMP:UniProtKB.
DR   GO; GO:0022404; P:molting cycle process; IMP:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0040034; P:regulation of development, heterochronic; IMP:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0040028; P:regulation of vulval development; IMP:UniProtKB.
DR   Gene3D; 1.20.120.2010; -; 1.
DR   InterPro; IPR006989; NAB_co-repressor_dom.
DR   InterPro; IPR039040; NAB_fam.
DR   InterPro; IPR006988; Nab_N.
DR   InterPro; IPR038398; NCD2_sf.
DR   PANTHER; PTHR12623; PTHR12623; 1.
DR   Pfam; PF04904; NCD1; 1.
DR   Pfam; PF04905; NCD2; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..582
FT                   /note="NAB transcription cofactor mab-10"
FT                   /id="PRO_0000452804"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          83..161
FT                   /note="NCD1"
FT                   /evidence="ECO:0000255"
FT   REGION          257..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..519
FT                   /note="NCD2"
FT                   /evidence="ECO:0000255"
FT   REGION          516..582
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..76
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..282
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        537..551
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         153..582
FT                   /note="Missing: In n5117; fail to exit the molting cycle
FT                   and inappropriately initiate an adult molt; effect more
FT                   common in males than in hermaphrodites."
FT                   /evidence="ECO:0000269|PubMed:21862562"
FT   MUTAGEN         157..582
FT                   /note="Missing: In n5118; fail to exit the molting cycle
FT                   and inappropriately initiate an adult molt; effect more
FT                   common in males than in hermaphrodites."
FT                   /evidence="ECO:0000269|PubMed:21862562"
SQ   SEQUENCE   582 AA;  61771 MW;  C02DBE3F88CA75F7 CRC64;
     MSSSSSSSLP TSSASTTTSS ITSRPSASHH LESILSSSSS SPSILSSLTT QSTSSIPTSS
     SSSSQRQSTS NADRPVSPKP MPTPTTLSEW QLLAVLSKAN LVQYYDVFIA QGGDDINQIM
     ACEEREFLEI MNLVGMLPKP LHVRRMQRAL AEYSQDQTAF NLAALQQIGP PPPLNYTPAG
     TDPMALLLPG IAAATSPKFP SLRFLSQLSS VAEKVSTPSE AADTSSSSPS LNLNTTSSNS
     VPLAFKFSTP LLESLASDQQ SSSTSSVRSV LPSTSSNTSH PELPAGILPA TTTNVSAAVP
     PPSSRATANV FSGNSIGLNF SGAASVTRHL VVPPSSTSIQ QPSTSFGRSS SITGQEKEGS
     SSPFLGVGYS QPYGNDFVSL GDFDPNNPSL TENPTLSTAQ ISRLAECALA ASKNLPPLPP
     RLVQNKKRVS KEVIELLKCS PATPSMIHAF RKYSAIYGRF DTKRKPHKVL TLHETTVNEA
     AAQLCLLVPS LLTRRDELFP LARQIVKDAG YNYAKSRKRP CDPADLHSPI SSPGNSPPPQ
     ESEFDEQPSS SSGAFKEEER PPIPPEAWAA IIEKMKGELP ES