MAB21_CAEEL
ID MAB21_CAEEL Reviewed; 364 AA.
AC Q20054; Q17337;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein male abnormal 21;
GN Name=mab-21; ORFNames=F35G12.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=Bristol N2;
RX PubMed=8582275; DOI=10.1242/dev.121.11.3615;
RA Chow K.L., Hall D.H., Emmons S.W.;
RT "The mab-21 gene of Caenorhabditis elegans encodes a novel protein required
RT for choice of alternate cell fates.";
RL Development 121:3615-3626(1995).
RN [2]
RP SEQUENCE REVISION TO 363-364.
RA Chow K.L.;
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP FUNCTION.
RX PubMed=10021351; DOI=10.1242/dev.126.6.1337;
RA Morita K., Chow K.L., Ueno N.;
RT "Regulation of body length and male tail ray pattern formation of
RT Caenorhabditis elegans by a member of TGF-beta family.";
RL Development 126:1337-1347(1999).
RN [5]
RP FUNCTION, AND INDUCTION.
RX PubMed=10545035; DOI=10.1046/j.1440-169x.1999.00459.x;
RA Chow K.L., Chan K.W.;
RT "Stress-induced phenocopy of C. elegans defines functional steps of sensory
RT organ differentiation.";
RL Dev. Growth Differ. 41:629-637(1999).
RN [6]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=11500979; DOI=10.1002/dvdy.1161;
RA Ho S.H., So G.M.K., Chow K.L.;
RT "Postembryonic expression of Caenorhabditis elegans mab-21 and its
RT requirement in sensory ray differentiation.";
RL Dev. Dyn. 221:422-430(2001).
RN [7]
RP FUNCTION.
RX PubMed=17506990; DOI=10.1016/j.bbrc.2007.04.194;
RA Choy S.W., Wong Y.-M., Ho S.H., Chow K.L.;
RT "C. elegans SIN-3 and its associated HDAC corepressor complex act as
RT mediators of male sensory ray development.";
RL Biochem. Biophys. Res. Commun. 358:802-807(2007).
CC -!- FUNCTION: Acts in a cell autonomous fashion to specify the properties
CC of the sensory ray and non-autonomously in the choice of hypodermal
CC versus neuroblast cell fate. {ECO:0000269|PubMed:10021351,
CC ECO:0000269|PubMed:10545035, ECO:0000269|PubMed:11500979,
CC ECO:0000269|PubMed:17506990, ECO:0000269|PubMed:8582275}.
CC -!- DEVELOPMENTAL STAGE: Expressed from the onset of gastrulation,
CC beginning with the dorsal hyp7 cells. Subsequently detected in other
CC cell types including hypodermal cells, neuronal cells near the
CC pharyngeal bulbs, neurons along the ventral nerve cord, the AVM, HOA,
CC HOB, PLM and VA3 neurons, some body wall muscles, and the ray cells.
CC During the L4 stage, expressed within neuron A of all ray cells, neuron
CC B of rays 3 and 6, and the structural cell of ray 6.
CC {ECO:0000269|PubMed:11500979}.
CC -!- INDUCTION: Transcription is repressed by heat shock.
CC {ECO:0000269|PubMed:10545035}.
CC -!- DISRUPTION PHENOTYPE: In the male tail, ray precursor cells show
CC altered fates. Conical sensory ray 6 is absent as it appears to fuse
CC with ray 4. Males show reduced body length and uncoordinated movement
CC in a backwards locomotion. Hermaphrodites produce a reduced brood size
CC due to a decreased number of laid eggs. {ECO:0000269|PubMed:8582275}.
CC -!- SIMILARITY: Belongs to the mab-21 family. {ECO:0000305}.
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DR EMBL; U19861; AAA97554.2; -; mRNA.
DR EMBL; Z46242; CAA86330.2; -; Genomic_DNA.
DR PIR; T21804; T21804.
DR RefSeq; NP_497940.2; NM_065539.5.
DR AlphaFoldDB; Q20054; -.
DR SMR; Q20054; -.
DR BioGRID; 40843; 2.
DR STRING; 6239.F35G12.6; -.
DR EPD; Q20054; -.
DR PaxDb; Q20054; -.
DR PeptideAtlas; Q20054; -.
DR EnsemblMetazoa; F35G12.6.1; F35G12.6.1; WBGene00003112.
DR GeneID; 175607; -.
DR KEGG; cel:CELE_F35G12.6; -.
DR UCSC; F35G12.6; c. elegans.
DR CTD; 44127; -.
DR WormBase; F35G12.6; CE32651; WBGene00003112; mab-21.
DR eggNOG; KOG3963; Eukaryota.
DR GeneTree; ENSGT01050000244827; -.
DR HOGENOM; CLU_045315_0_0_1; -.
DR InParanoid; Q20054; -.
DR OMA; AVDKCKY; -.
DR OrthoDB; 771781at2759; -.
DR PhylomeDB; Q20054; -.
DR SignaLink; Q20054; -.
DR PRO; PR:Q20054; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003112; Expressed in larva and 3 other tissues.
DR GO; GO:0045165; P:cell fate commitment; IMP:WormBase.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0090597; P:nematode male tail mating organ morphogenesis; IMP:UniProtKB.
DR InterPro; IPR024810; Mab-21_dom.
DR Pfam; PF03281; Mab-21; 1.
DR SMART; SM01265; Mab-21; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Reference proteome.
FT CHAIN 1..364
FT /note="Protein male abnormal 21"
FT /id="PRO_0000312802"
SQ SEQUENCE 364 AA; 41523 MW; 70D469470367B30F CRC64;
MLGHNQNVVY QVNNYFNEKV QHRKVRVTKT VQRIAKVVQE ILKEVEAQEP RFINTLSETT
TGRFDGIVVH SPSEYEAVLY LNQMGVFNFV DDGTIQGCAV LKLSDGRKRS MSLWVEFITA
SGYLSARKIR HRFQNIVAQV LQTPQFSDYC KLLQDNTDVR VRVDDKYTVQ ITCAFRCNGI
WPRSASHWPI AGLPWPNAAL ANQTKAEGFD LTSRETAITQ QNNPNKQASS MEADAWAMKM
HGAENMLLTG GRRKTLSILK CLRDAHMDFP GTPVTNYILK TLVLYECEKH CSEYEWEDPN
IGDRLVGILL QLVSCLQCRR CAHYFLPSLD LLRSKPVHSI EHSAQLAWHL VRKLMIDPNA
LQSL
