ID   MAB21_DROME             Reviewed;         365 AA.
AC   Q9U3W6; Q9W447;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Protein mab-21;
GN   Name=mab-21; ORFNames=CG4746;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Serano T.L., Pendleton J.D., Rubin G.M.;
RT   "A reverse genetic screen for genes involved in Drosophila development.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- SIMILARITY: Belongs to the mab-21 family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF24503.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF214524; AAF24503.1; ALT_INIT; mRNA.
DR   EMBL; AE014298; AAF46112.2; -; Genomic_DNA.
DR   EMBL; AY128466; AAM75059.1; -; mRNA.
DR   RefSeq; NP_651971.2; NM_143714.4.
DR   AlphaFoldDB; Q9U3W6; -.
DR   SMR; Q9U3W6; -.
DR   BioGRID; 68848; 2.
DR   IntAct; Q9U3W6; 2.
DR   STRING; 7227.FBpp0070855; -.
DR   PaxDb; Q9U3W6; -.
DR   DNASU; 44127; -.
DR   EnsemblMetazoa; FBtr0070890; FBpp0070855; FBgn0029003.
DR   GeneID; 44127; -.
DR   KEGG; dme:Dmel_CG4746; -.
DR   UCSC; CG4746-RA; d. melanogaster.
DR   CTD; 44127; -.
DR   FlyBase; FBgn0029003; mab-21.
DR   VEuPathDB; VectorBase:FBgn0029003; -.
DR   eggNOG; KOG3963; Eukaryota.
DR   GeneTree; ENSGT01050000244827; -.
DR   HOGENOM; CLU_045315_0_0_1; -.
DR   InParanoid; Q9U3W6; -.
DR   PhylomeDB; Q9U3W6; -.
DR   BioGRID-ORCS; 44127; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 44127; -.
DR   PRO; PR:Q9U3W6; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0029003; Expressed in imaginal disc and 22 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:FlyBase.
DR   GO; GO:0005634; C:nucleus; ISS:FlyBase.
DR   GO; GO:0001654; P:eye development; ISS:FlyBase.
DR   InterPro; IPR024810; Mab-21_dom.
DR   Pfam; PF03281; Mab-21; 1.
DR   SMART; SM01265; Mab-21; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..365
FT                   /note="Protein mab-21"
FT                   /id="PRO_0000312795"
FT   CONFLICT        70
FT                   /note="Q -> E (in Ref. 1; AAF24503)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        215
FT                   /note="N -> D (in Ref. 1; AAF24503)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   365 AA;  41863 MW;  1154CDA58257BB29 CRC64;
     MLVPSDMIAA QSKMVYQMNK YCADRVQVRK AQIHKQIQEV CRIVQDVLKE VEVQEPRFIS
     SLNDYNGRFQ GLEVISPTEF EIIIYLNQMG VLNFVDDGTL PGCAVLKLSD GRKRSMSLWV
     EFITASGYLS ARKIRSRFQT LVAQACDKCA YRDIVKMIAD TTEVKLRIRE RIIVQITPAF
     KCAGLWPRSA SHWPLPGIPW PHPNIVAEVK TEGFNMLSKE CIALQGKNSA MEGDAWVLSF
     TDAENRLLQG ASRRRCLSIL KTLRDRHLDL PGNPVTSYHL KTLLLYECEK HPREMEWEEN
     CIADRINGIF LQLISCLQCR RCPHYFLPNM DLFKGKSPGA LENAAKQVWR LTRIMLTNVR
     CLEEL