MAB5_CAEEL
ID MAB5_CAEEL Reviewed; 200 AA.
AC P10038; Q9GZ02;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 3.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=Homeobox protein mab-5;
DE AltName: Full=Protein male abnormal 5;
GN Name=mab-5 {ECO:0000312|WormBase:C08C3.3};
GN ORFNames=C08C3.3 {ECO:0000312|WormBase:C08C3.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=2903796; DOI=10.1016/0092-8674(88)90131-6;
RA Costa M., Wir M., Coulson A., Sulston J., Kenyon C.;
RT "Posterior pattern formation in C. elegans involves position-specific
RT expression of a gene containing a homeobox.";
RL Cell 55:747-756(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Grandien K., Sommer R.J.;
RT "Determination of 5'-end of Caenorhabditis elegans mab-5 cDNA demonstrates
RT a shorter N-terminal region than previously predicted.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=8898225; DOI=10.1242/dev.122.10.3117;
RA Harris J., Honigberg L., Robinson N., Kenyon C.;
RT "Neuronal cell migration in C. elegans: regulation of Hox gene expression
RT and cell position.";
RL Development 122:3117-3131(1996).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=15371357; DOI=10.1534/genetics.104.031781;
RA Forrester W.C., Kim C., Garriga G.;
RT "The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in
RT cell migration.";
RL Genetics 168:1951-1962(2004).
RN [7]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21307099; DOI=10.1242/dev.062240;
RA Tian C., Shi H., Colledge C., Stern M., Waterston R., Liu J.;
RT "The C. elegans SoxC protein SEM-2 opposes differentiation factors to
RT promote a proliferative blast cell fate in the postembryonic mesoderm.";
RL Development 138:1033-1043(2011).
RN [8]
RP FUNCTION.
RX PubMed=23784779; DOI=10.1073/pnas.1301849110;
RA Wang X., Zhou F., Lv S., Yi P., Zhu Z., Yang Y., Feng G., Li W., Ou G.;
RT "Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the
RT cell polarity in neuronal migration.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:11175-11180(2013).
CC -!- FUNCTION: Transcription factor that binds to the promoter region of the
CC transcription factor lin-39 to repress its expression in Q neuroblasts
CC and thereby direct left Q neuroblast (QL) daughter cell migration
CC (PubMed:8898225, PubMed:23784779). During postembryonic development,
CC required for posterior-specific pattern formation (PubMed:2903796).
CC Within the posterior body region, controls epidermal, neuronal, and
CC mesodermal cell differentiation (PubMed:2903796, PubMed:21307099).
CC {ECO:0000269|PubMed:21307099, ECO:0000269|PubMed:23784779,
CC ECO:0000269|PubMed:2903796, ECO:0000269|PubMed:8898225}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed asymmetrically in the QL neuroblast.
CC {ECO:0000269|PubMed:15371357}.
CC -!- DISRUPTION PHENOTYPE: Defective QL neuroblast daughter cell migration
CC (PubMed:8898225). Lin-39 and mab-5 double mutants have reduced sex
CC myoblast specific expression of sem-2 in the developing mesoderm
CC (PubMed:21307099). {ECO:0000269|PubMed:21307099,
CC ECO:0000269|PubMed:8898225}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA28106.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M22751; AAA28106.1; ALT_INIT; mRNA.
DR EMBL; AF277990; AAG00458.1; -; mRNA.
DR EMBL; FO080429; CCD63641.1; -; Genomic_DNA.
DR PIR; S44615; S44615.
DR RefSeq; NP_498695.1; NM_066294.5.
DR AlphaFoldDB; P10038; -.
DR SMR; P10038; -.
DR BioGRID; 41299; 8.
DR IntAct; P10038; 7.
DR STRING; 6239.C08C3.3; -.
DR EPD; P10038; -.
DR PaxDb; P10038; -.
DR PeptideAtlas; P10038; -.
DR EnsemblMetazoa; C08C3.3.1; C08C3.3.1; WBGene00003102.
DR GeneID; 176091; -.
DR KEGG; cel:CELE_C08C3.3; -.
DR UCSC; C08C3.3; c. elegans.
DR CTD; 176091; -.
DR WormBase; C08C3.3; CE25765; WBGene00003102; mab-5.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000171134; -.
DR HOGENOM; CLU_061398_1_1_1; -.
DR InParanoid; P10038; -.
DR OMA; TGDDSYW; -.
DR OrthoDB; 1386702at2759; -.
DR PhylomeDB; P10038; -.
DR SignaLink; P10038; -.
DR PRO; PR:P10038; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003102; Expressed in V5L.p (C elegans) and 8 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IDA:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:WormBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0090597; P:nematode male tail mating organ morphogenesis; IMP:WormBase.
DR GO; GO:0097402; P:neuroblast migration; IGI:UniProtKB.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:WormBase.
DR GO; GO:0048337; P:positive regulation of mesodermal cell fate specification; IGI:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0042659; P:regulation of cell fate specification; IMP:WormBase.
DR GO; GO:0030334; P:regulation of cell migration; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..200
FT /note="Homeobox protein mab-5"
FT /id="PRO_0000049171"
FT DNA_BIND 115..175
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 164..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 103..108
FT /note="Antp-type hexapeptide"
SQ SEQUENCE 200 AA; 22399 MW; EAC2DCA86F54E7E3 CRC64;
MSMYPGWTGD DSYWAGAGTT ASSQSASSGT SASASSSAAA AAAANNLKTY ELYNHTYMNN
MKHMLAAGWM DNSSNPFAYN PLQATSANFG ETRTSMPAIS QPVFPWMKMG GAKGGESKRT
RQTYSRSQTL ELEKEFHYHK YLTRKRRQEI SETLHLTERQ VKIWFQNRRM KHKKEAKGEG
GSNESDEESN QDEQNEQHSS
