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MAB7_CAEEL
ID   MAB7_CAEEL              Reviewed;         287 AA.
AC   Q95Q39; Q3L453;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Protein male abnormal 7;
GN   Name=mab-7 {ECO:0000312|WormBase:ZC13.4}; ORFNames=ZC13.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAW59416.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, DEVELOPMENTAL STAGE, DOMAIN, AND MUTAGENESIS OF CYS-67 AND
RP   CYS-108.
RX   PubMed=17959165; DOI=10.1016/j.ydbio.2007.09.037;
RA   Tsang S.W., Nguyen C.Q., Hall D.H., Chow K.L.;
RT   "mab-7 encodes a novel transmembrane protein that orchestrates sensory ray
RT   morphogenesis in C. elegans.";
RL   Dev. Biol. 312:353-366(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Plays an important role in determining body shape and sensory
CC       ray morphology, possibly by acting as a signaling molecule outside the
CC       expressing cell. {ECO:0000269|PubMed:17959165}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17959165};
CC       Single-pass type II membrane protein {ECO:0000269|PubMed:17959165}.
CC   -!- TISSUE SPECIFICITY: Expressed in hypodermis first at the two-fold stage
CC       and throughout the larval stages but not at the adult stage. Detected
CC       in the body seams after the L4 stage with expression maintained in
CC       adults. Detected in the male tail structural cells at the late L4 stage
CC       and also maintained in adults. Detected at different developmental
CC       stages in vulva, PQR neurons and several neuronal processes in the head
CC       region. {ECO:0000269|PubMed:17959165}.
CC   -!- DOMAIN: The EGF-like domain and the SXC (ShKT) domain are essential for
CC       the biological activity of the protein. May function as protein
CC       interaction domains. {ECO:0000269|PubMed:17959165}.
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DR   EMBL; AY742796; AAW59416.1; -; mRNA.
DR   EMBL; FO081302; CCD70627.1; -; Genomic_DNA.
DR   RefSeq; NP_508174.2; NM_075773.4.
DR   AlphaFoldDB; Q95Q39; -.
DR   SMR; Q95Q39; -.
DR   STRING; 6239.ZC13.4; -.
DR   EPD; Q95Q39; -.
DR   PaxDb; Q95Q39; -.
DR   PeptideAtlas; Q95Q39; -.
DR   EnsemblMetazoa; ZC13.4.1; ZC13.4.1; WBGene00003104.
DR   GeneID; 180440; -.
DR   KEGG; cel:CELE_ZC13.4; -.
DR   UCSC; ZC13.4; c. elegans.
DR   CTD; 180440; -.
DR   WormBase; ZC13.4; CE41485; WBGene00003104; mab-7.
DR   eggNOG; KOG3371; Eukaryota.
DR   GeneTree; ENSGT00970000196680; -.
DR   HOGENOM; CLU_1035278_0_0_1; -.
DR   InParanoid; Q95Q39; -.
DR   OMA; RWALEDK; -.
DR   OrthoDB; 986766at2759; -.
DR   PhylomeDB; Q95Q39; -.
DR   PRO; PR:Q95Q39; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00003104; Expressed in embryo and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd07828; lipocalin_heme-bd-THAP4-like; 1.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR045165; Nitrobindin.
DR   InterPro; IPR003582; ShKT_dom.
DR   InterPro; IPR014878; THAP4-like_heme-bd.
DR   PANTHER; PTHR15854; PTHR15854; 1.
DR   SMART; SM00181; EGF; 1.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS51670; SHKT; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Developmental protein; Disulfide bond; EGF-like domain;
KW   Glycoprotein; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..287
FT                   /note="Protein male abnormal 7"
FT                   /id="PRO_0000409248"
FT   TRANSMEM        1..22
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000269|PubMed:17959165"
FT   TOPO_DOM        23..287
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          34..68
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          71..108
FT                   /note="ShKT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   CARBOHYD        174
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        229
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        38..49
FT                   /evidence="ECO:0000255"
FT   DISULFID        43..56
FT                   /evidence="ECO:0000255"
FT   DISULFID        58..67
FT                   /evidence="ECO:0000255"
FT   MUTAGEN         67
FT                   /note="C->Y: In allele e1599; hermaphrodites and adult
FT                   males appear slightly dumpy, with males having swollen
FT                   bursal rays and much lower mating efficiency than that of
FT                   wild-type males. When subjected to RNAi knock-down of mab-7
FT                   gene, no obvious enhancement of severity in phenotype was
FT                   observed."
FT                   /evidence="ECO:0000269|PubMed:17959165"
FT   MUTAGEN         108
FT                   /note="C->Y: In allele wx74; hermaphrodites and adult males
FT                   appear slightly dumpy, with males having swollen bursal
FT                   rays and much lower mating efficiency than that of wild-
FT                   type males. When subjected to RNAi knock-down of mab-7
FT                   gene, no obvious enhancement of severity in phenotype was
FT                   observed."
FT                   /evidence="ECO:0000269|PubMed:17959165"
SQ   SEQUENCE   287 AA;  32344 MW;  CEF52C1C6A3C8F16 CRC64;
     MTITRILTCL LICLFIRIPA AGTKTTQLIF KRFTEETCQN DPCLNGGTCT PGKLSCTCAT
     GWMGRYCHRK CRNIYKSCDR WAVEDKCHTI LTQTNFFDVN CAISCKMCSP DPNYVAPEIP
     LAPALEPMQF FLGKWHSRAS KGLRFPTDLY DTEYEEIIDI APANVPMFGP PSLNFTSTSW
     FGDDTRVVHG FITLKPNSFP PEVAILSTSN EGLNMIELGT LKHHVLTLNV SYMQVHPTMD
     SKVLPLGATR RLRRVGSLLE MTVAKLFSEN KVSQFKKMFK KIADYAF
 
 
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