MABI_DROME
ID MABI_DROME Reviewed; 206 AA.
AC Q9VK13;
DT 06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Protein Mabiki {ECO:0000312|EMBL:AAF53269.1};
GN Name=Mabi {ECO:0000312|FlyBase:FBgn0032493};
GN ORFNames=CG15479 {ECO:0000312|FlyBase:FBgn0032493};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:ABC86434.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Celniker S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=24671768; DOI=10.1534/genetics.114.163337;
RA Tanaka K.M., Takahashi A., Fuse N., Takano-Shimizu-Kouno T.;
RT "A novel cell death gene acts to repair patterning defects in Drosophila
RT melanogaster.";
RL Genetics 197:739-742(2014).
CC -!- FUNCTION: Plays a role in inducing apoptosis and is involved in the
CC repair of head patterning defects in the embryo caused by extra
CC maternal copies of the homeotic gene bicoid.
CC {ECO:0000269|PubMed:24671768}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout the embryo at stage 11 with a
CC higher level in the anterior region. At stage 12, a few cells show
CC expression. {ECO:0000269|PubMed:24671768}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethality with increased frequency of
CC embryonic head defects and reduced embryonic cell death.
CC {ECO:0000269|PubMed:24671768}.
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DR EMBL; AE014134; AAF53269.1; -; Genomic_DNA.
DR EMBL; BT024372; ABC86434.1; -; mRNA.
DR RefSeq; NP_609624.1; NM_135780.3.
DR AlphaFoldDB; Q9VK13; -.
DR SMR; Q9VK13; -.
DR IntAct; Q9VK13; 5.
DR PaxDb; Q9VK13; -.
DR DNASU; 34727; -.
DR EnsemblMetazoa; FBtr0080481; FBpp0080060; FBgn0032493.
DR GeneID; 34727; -.
DR KEGG; dme:Dmel_CG15479; -.
DR UCSC; CG15479-RA; d. melanogaster.
DR CTD; 34727; -.
DR FlyBase; FBgn0032493; Mabi.
DR VEuPathDB; VectorBase:FBgn0032493; -.
DR eggNOG; ENOG502T801; Eukaryota.
DR HOGENOM; CLU_1333192_0_0_1; -.
DR InParanoid; Q9VK13; -.
DR OMA; NKNTIAC; -.
DR OrthoDB; 1294597at2759; -.
DR PhylomeDB; Q9VK13; -.
DR Reactome; R-DME-9616222; Transcriptional regulation of granulopoiesis.
DR SignaLink; Q9VK13; -.
DR BioGRID-ORCS; 34727; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 34727; -.
DR PRO; PR:Q9VK13; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0032493; Expressed in yolk nucleus (Drosophila) and 4 other tissues.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR046347; bZIP_sf.
DR SUPFAM; SSF57959; SSF57959; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Reference proteome.
FT CHAIN 1..206
FT /note="Protein Mabiki"
FT /id="PRO_0000436600"
FT REGION 54..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 206 AA; 24047 MW; C19CDE688A0D75B1 CRC64;
MEHHQIYRHK KFDMGRKIEK CDLQLKEELI SRSGTPCTSR SPFDAANQSV SLGFSDQDAD
FPPLPKRRRL GSSSSSVSYQ SASPIITEAI QDIFKYHVNM VRKFPKKERS PKDQERRNKN
TIACRMSRRK KKFDDLQIEQ QYKECSDEHL KIAEQSLRAR VYLNHLKQLV KQEDHPLVSS
RRVPEENTKS NFSIDYLIGG IKQEHA
