ID   MABP1_XENLA             Reviewed;        1580 AA.
AC   Q6DFF9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Mitogen-activated protein kinase-binding protein 1;
GN   Name=mapkbp1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in JNK signaling pathway. {ECO:0000250}.
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DR   EMBL; BC076779; AAH76779.1; -; mRNA.
DR   RefSeq; NP_001086542.1; NM_001093073.1.
DR   AlphaFoldDB; Q6DFF9; -.
DR   PRIDE; Q6DFF9; -.
DR   DNASU; 446377; -.
DR   GeneID; 446377; -.
DR   KEGG; xla:446377; -.
DR   CTD; 446377; -.
DR   Xenbase; XB-GENE-865533; mapkbp1.L.
DR   OrthoDB; 1017450at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 446377; Expressed in egg cell and 19 other tissues.
DR   Gene3D; 2.130.10.10; -; 4.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 12.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1580
FT                   /note="Mitogen-activated protein kinase-binding protein 1"
FT                   /id="PRO_0000334160"
FT   REPEAT          90..131
FT                   /note="WD 1"
FT   REPEAT          134..175
FT                   /note="WD 2"
FT   REPEAT          177..215
FT                   /note="WD 3"
FT   REPEAT          273..311
FT                   /note="WD 4"
FT   REPEAT          338..377
FT                   /note="WD 5"
FT   REPEAT          383..432
FT                   /note="WD 6"
FT   REPEAT          476..515
FT                   /note="WD 7"
FT   REPEAT          518..560
FT                   /note="WD 8"
FT   REPEAT          564..605
FT                   /note="WD 9"
FT   REPEAT          614..653
FT                   /note="WD 10"
FT   REPEAT          659..698
FT                   /note="WD 11"
FT   REPEAT          701..740
FT                   /note="WD 12"
FT   REGION          749..811
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          820..839
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          968..1026
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1211..1233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1369..1397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1519..1555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        756..781
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        820..837
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        968..982
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1522..1538
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1539..1554
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1580 AA;  174157 MW;  5468A3A6FE5B9D5F CRC64;
     MATIESGTTI TSRLKNLLRS PSIKLRRHKA GTKKEDLSSK VTLEKVLGIT VSAGRGLSCD
     PKTGLVAYPA GCVVVLLNPR KNKQQHILNS SRKTITALAF SPDGKFLVTG ESGHMPAVRV
     WDVAERTQVA ELQEHKYGVA CVAFSPTSKY IVSVGYQHDM IVNVWSWKKN VVVAANKVSS
     KVTAVSFSED SSYFVTAGNR HVKFWYLDEA KSSKVNSTIP LLGRSGLLGE LRNNFFTDVA
     CGKSKKSSST FCITSSGLLC EFNDQRLLDK WVELRTTVAN CILVNHDYIF CGCADGTVRI
     FNPNNLHFLS TMPKPHCLGV DIATVTEASR LFSSAADAKY PDTIAMTFDP TNQWLSCVYN
     DHSLYVWDVK DLKKVGKVYS SLYHSSCVWS IEIYPEIKDS NQACLPPNSF ITCSSDSTIR
     LWNMETSNIH GTALHRNILS NDLMKIILID DNTQALLDTE YNSAGLGDKA DHQALDTKVG
     IRSVCVSPNG QHLASGDRTG TLRVHELQSM TELLKVEAHD SEILCLEYSK PDTGLNLLAS
     ASRDRLIHVL DASKDYSLQQ TLDDHSSSIT AVKFAANDGK VQMISCGADK SIYFRTADKV
     GDAAVHFTRT HHIVRKTTLY DMDVDPSLKY AAIGCQDRNI RIFNISSGKQ KKLYKGSQSE
     DGTLIKVQTD PSGLYIATSC SDKNLSIFDF YSGECVATMF GHSEVVTGMK FTNDCKHLIS
     VSGDSCVFIW RLSSEMTINM RQRLAEVRQR GKQVEMSATH KTQNARRETI AVMSTAPVMS
     SDSDKEGVED GSDEDTAGSD KASSASSSFG RSNSYWEMAR GTNTSSERSN CLSKMPRQRV
     RWSQPAGNIE MTVKSMLDLR QLDSFAPCDD IIGFQPSEGL GTEFVVADNS SIQAPFGPIG
     SRSRPRVIRL MSCEETMFKQ DVETPEGKEC TIFPEMEEDE SLERCGGFEV KGLPLRSYHD
     NVCQEKHSPD SACSVDYSSR LSSPEHPNED SESTEPLSVD ANSSDLEEQV EAEDLEPNSP
     VMDGEIPQTP DQEKFLKQHF GNLSAGNIPG GPLLTSERND FSSISSRFLA MAAPSKNQPV
     ESLMFDSEFS PALFQPSMEH PALINRTESQ PKSAITTDHD FTSPQKLNYF QRKRKHLQEY
     EHIGKGGPFS SVMQIRKTQS VHDLVNEGNK TTANGGIVKM RSQVQTAAER EEKAIRRRTL
     PSTLIKVENL ASGTPHSKDG KLAKGRSYMN PTTSSMAKIS RSMSVGENLN IEENQDASLS
     FDGKGNCEPE IGAIPSFVET EKNRQTAKET VIIKPHLQPV ANCSSTKTFQ TKNRAHLTLD
     IAKPLPDRPL LSFNKGKGAL EMESPRSPAS SCKVKSSFSE FTCRNDNQAS GALEKTSPSE
     DYGCSKSKEN DVKANSKPNV YQERVELFSD MLKPIHRGRA STIGHTPDHH SGLCPEVEPI
     RPRSPSLNAA PTHNSASSVS FEQCELIASE LQDSLQKALS LYRSVTTADP SANMERCKIA
     GLLTETFGMV KRELDFLKEG NSSPGTAMTP QDETGSDFTA PNLHEEHGTR RLGDDKTLAL
     LQQYSELLLQ AVEKRMDKKL