ID   MACB_BARHE              Reviewed;         660 AA.
AC   Q6G1V5;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Macrolide export ATP-binding/permease protein MacB {ECO:0000255|HAMAP-Rule:MF_01720};
DE            EC=7.6.2.- {ECO:0000255|HAMAP-Rule:MF_01720};
GN   Name=macB {ECO:0000255|HAMAP-Rule:MF_01720}; OrderedLocusNames=BH15460;
OS   Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)
OS   (Rochalimaea henselae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283166;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: Non-canonical ABC transporter that contains transmembrane
CC       domains (TMD), which form a pore in the inner membrane, and an ATP-
CC       binding domain (NBD), which is responsible for energy generation.
CC       Confers resistance against macrolides. {ECO:0000255|HAMAP-
CC       Rule:MF_01720}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01720}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01720}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01720}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Macrolide
CC       exporter (TC 3.A.1.122) family. {ECO:0000255|HAMAP-Rule:MF_01720}.
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DR   EMBL; BX897699; CAF28309.1; -; Genomic_DNA.
DR   RefSeq; WP_011181312.1; NZ_LRIJ02000001.1.
DR   AlphaFoldDB; Q6G1V5; -.
DR   SMR; Q6G1V5; -.
DR   STRING; 283166.BH15460; -.
DR   PaxDb; Q6G1V5; -.
DR   PRIDE; Q6G1V5; -.
DR   EnsemblBacteria; CAF28309; CAF28309; BH15460.
DR   GeneID; 64157685; -.
DR   KEGG; bhe:BH15460; -.
DR   eggNOG; COG0577; Bacteria.
DR   eggNOG; COG1136; Bacteria.
DR   OMA; NEIGVRM; -.
DR   Proteomes; UP000000421; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR017911; MacB_ATP-bd.
DR   InterPro; IPR025857; MacB_PCD.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF12704; MacB_PCD; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51267; MACB; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; ATP-binding; Cell inner membrane; Cell membrane;
KW   Membrane; Nucleotide-binding; Translocase; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..660
FT                   /note="Macrolide export ATP-binding/permease protein MacB"
FT                   /id="PRO_0000269921"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        532..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        593..613
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        625..645
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   DOMAIN          10..248
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   BINDING         46..53
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
SQ   SEQUENCE   660 AA;  72232 MW;  440391550AF991B4 CRC64;
     MKAKQADAVL VLENIVRKFP AGETFVTVLK DINLTIKRGE MVAIVGASGS GKSTLMNILG
     CLDRPTFGRY WISGKETASL SADELSALRR NHFGFIFQRY HLLNELTALG NVEIPAVYAG
     YAPEVRRKRA EDLLTRLGMR DRIHHRPNQL SGGQQQRVSI ARALMNNAEV ILADEPTGAL
     DKKSGQEVLR ILDELHQEGR TIIMVTHDMQ VAERADRIIE ISDGEIIADN VSKVAKTKTD
     SQALYGKQVL KDQKTLGFFR SFAERFREAF VMALLAMNAH RMRTFLTMLG VIIGIGAIIA
     MVALGNGTRE KILENFKSLG SNTLTILPGK SLSDPQAEKI TSLVEADAEA LSKLPYVSGV
     TPQMSASSTI RFGSVEADVV IAGVGEQYFQ TQGLNAVQGR LFDQKSVHDR AIDLVIEKEA
     LAVLFPHSHE SPLGKVVHVG NVPVRIVGVI DPQHNGGTSS TLQVYLPYTT VQTRFLGTTQ
     VRAITVKIAD TVDSNLAETM VRRFLIMRHG EEDFFIRNSQ LFRDRIMEST HILTLLVSSI
     AAISLIVGGI GVMNIMLVTV SERINEIGVR MAVGARQSDI LQQFLIEAIL VCVIGGGLGI
     LFGMSIGGLF LLFKAPIHLI YTIDSIILSL TFSTLIGVCF GFSPARQASR LDPVVALSRD