ID   MACB_CAMFF              Reviewed;         641 AA.
AC   A0RP01;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Macrolide export ATP-binding/permease protein MacB {ECO:0000255|HAMAP-Rule:MF_01720};
DE            EC=7.6.2.- {ECO:0000255|HAMAP-Rule:MF_01720};
GN   Name=macB {ECO:0000255|HAMAP-Rule:MF_01720};
GN   OrderedLocusNames=CFF8240_0759;
OS   Campylobacter fetus subsp. fetus (strain 82-40).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=360106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=82-40;
RA   Fouts D.E., Nelson K.E.;
RT   "Sequence of Campylobacter fetus subsp. fetus 82-40.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non-canonical ABC transporter that contains transmembrane
CC       domains (TMD), which form a pore in the inner membrane, and an ATP-
CC       binding domain (NBD), which is responsible for energy generation.
CC       Confers resistance against macrolides. {ECO:0000255|HAMAP-
CC       Rule:MF_01720}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01720}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01720}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01720}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Macrolide
CC       exporter (TC 3.A.1.122) family. {ECO:0000255|HAMAP-Rule:MF_01720}.
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DR   EMBL; CP000487; ABK82901.1; -; Genomic_DNA.
DR   RefSeq; WP_002849183.1; NC_008599.1.
DR   AlphaFoldDB; A0RP01; -.
DR   SMR; A0RP01; -.
DR   STRING; 360106.CFF8240_0759; -.
DR   PRIDE; A0RP01; -.
DR   EnsemblBacteria; ABK82901; ABK82901; CFF8240_0759.
DR   GeneID; 61064598; -.
DR   KEGG; cff:CFF8240_0759; -.
DR   PATRIC; fig|360106.6.peg.733; -.
DR   eggNOG; COG0577; Bacteria.
DR   eggNOG; COG1136; Bacteria.
DR   HOGENOM; CLU_000604_78_1_7; -.
DR   OMA; NEIGVRM; -.
DR   OrthoDB; 1181903at2; -.
DR   Proteomes; UP000000760; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR017911; MacB_ATP-bd.
DR   InterPro; IPR025857; MacB_PCD.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF12704; MacB_PCD; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51267; MACB; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; ATP-binding; Cell inner membrane; Cell membrane;
KW   Membrane; Nucleotide-binding; Translocase; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..641
FT                   /note="Macrolide export ATP-binding/permease protein MacB"
FT                   /id="PRO_0000280164"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        516..536
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        565..585
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        601..621
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   DOMAIN          2..240
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   BINDING         38..45
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
SQ   SEQUENCE   641 AA;  70007 MW;  9D724E789EC6EB5B CRC64;
     MIKLENIKKS FITGGVSSEV LKGINLEIKK GEFVAIIGQS GSGKSTLMNI LGCLDTPTSG
     KYLLDSLDIS KFKKDELSNL RLKKFGFIFQ RYNLLSSNDT KSNVALPGIY AGMSKADRIN
     RAKDILVKLG LETKFDTMPN HLSGGQQQRV SIARALMNGG EILLCDEPTG ALDSSSGVMV
     MQILDSLHKD GHTIIVVTHD KDIAAWADRI IEIKDGNIIS DTRKNSQIYE LKQNLKEIKP
     SLKAIRDQFF ESFVMSLGAI KSHKLRSFLT MLGIIIGIAS VICVVALAKG SQQKILSDIN
     NMGTNTITIF PGKGFGDMHS GRVRSLSIDD SNLLGKLDFV DFSTPRMNTS GLLTYANQSF
     SGSLRSGSEY SLAISGLKIE KGRDFTKDDI INSRSNIIID QFTKDAFFKD VDPIGKVILF
     NKQPFTIVGL VKRDETSFSG DNLTVYAPYT TTMNKLTGDR DIRSIMLKLK DGVNAQVAEQ
     SIIEVLKIRR GSKDFFTRNS DTIRQTIEST MNTMSLLISG IALISLMVGG IGVMNIMLVS
     VFERTKEIGI RMAIGAKSKD IMTQFLIEAI LLCAIGGSIG IGLAYAIGYG FNVFGGDFKM
     IFSTASIFIA LGVSSLIGIV FGYIPARNAS KLNPIDALLR E