ID   MACB_CAMJJ              Reviewed;         641 AA.
AC   A1VYW8;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Macrolide export ATP-binding/permease protein MacB {ECO:0000255|HAMAP-Rule:MF_01720};
DE            EC=7.6.2.- {ECO:0000255|HAMAP-Rule:MF_01720};
GN   Name=macB {ECO:0000255|HAMAP-Rule:MF_01720};
GN   OrderedLocusNames=CJJ81176_0636;
OS   Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=354242;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=81-176;
RA   Fouts D.E., Nelson K.E., Sebastian Y.;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non-canonical ABC transporter that contains transmembrane
CC       domains (TMD), which form a pore in the inner membrane, and an ATP-
CC       binding domain (NBD), which is responsible for energy generation.
CC       Confers resistance against macrolides. {ECO:0000255|HAMAP-
CC       Rule:MF_01720}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01720}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01720}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01720}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Macrolide
CC       exporter (TC 3.A.1.122) family. {ECO:0000255|HAMAP-Rule:MF_01720}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000538; EAQ73027.1; -; Genomic_DNA.
DR   RefSeq; WP_002856958.1; NC_008787.1.
DR   AlphaFoldDB; A1VYW8; -.
DR   SMR; A1VYW8; -.
DR   STRING; 354242.CJJ81176_0636; -.
DR   EnsemblBacteria; EAQ73027; EAQ73027; CJJ81176_0636.
DR   KEGG; cjj:CJJ81176_0636; -.
DR   eggNOG; COG0577; Bacteria.
DR   eggNOG; COG1136; Bacteria.
DR   HOGENOM; CLU_000604_78_2_7; -.
DR   OMA; VVILITH; -.
DR   Proteomes; UP000000646; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR017911; MacB_ATP-bd.
DR   InterPro; IPR025857; MacB_PCD.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF12704; MacB_PCD; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51267; MACB; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; ATP-binding; Cell inner membrane; Cell membrane;
KW   Membrane; Nucleotide-binding; Translocase; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..641
FT                   /note="Macrolide export ATP-binding/permease protein MacB"
FT                   /id="PRO_0000280165"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        519..539
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        571..591
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        604..624
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   DOMAIN          2..236
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   BINDING         34..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
SQ   SEQUENCE   641 AA;  70219 MW;  C77C7D6BD7E87863 CRC64;
     MIFLKNICKN IGENAILKNV SLSIEKGEFV AIIGQSGSGK TSLLNIIGTL DTPSSGTYVF
     DEYEVTKLNN DEKARLRREK IGFIFQRYNL LSLLSAKENV SLPAVYAGKK LQERSQNAKK
     LLNDLELAHK LDSKPNELSG GQQQRVSIAR ALMNGGELIL ADEPTGALDS KSGIMVLEIL
     QKLNAQGHTI VLVTHDPKIA AQAKRVIEIK DGEILSDTKK EKAQEKLTLK TMSKEKKTLT
     LLKNQAFECF KIAYSSILAH KLRSILTMLG IIIGIASVVC VVALGLGSQA KVLESIARLG
     TNTIEIRPGR GFGDLRSGKT RLNFSDLETL RSLEYLEAVD AHSNTSGVAT YTNISLSARA
     EGVGVNNFAI EGLRIDAGRI LNNDDVKNST NVAVLDFNAK KNLFPDEKSE NILGRVVLFN
     SQPFKIIGVL QKDTDKPIED NVVRLYIPYT TLMNKLTGDR NLREIIVKVK DDVSSTLAEN
     AIIRILEIKR GQKDFFTFNS DTFKQAITAN KRTTTILTAC VAVIALIVGG IGVMNIMLVS
     VSERTREIGI RMAIGARRED IMMQFLIEAV MICTIGAILG VILSIFVIFA FNTLSTDFPM
     ILNAYSVLLG LLSSMFIGVV FGFFPARNAA NLNPISALSK E