ID   MACB_CHLL3              Reviewed;         664 AA.
AC   Q3B5J7;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Macrolide export ATP-binding/permease protein MacB {ECO:0000255|HAMAP-Rule:MF_01720};
DE            EC=7.6.2.- {ECO:0000255|HAMAP-Rule:MF_01720};
GN   Name=macB {ECO:0000255|HAMAP-Rule:MF_01720}; OrderedLocusNames=Plut_0496;
OS   Chlorobium luteolum (strain DSM 273 / BCRC 81028 / 2530) (Pelodictyon
OS   luteolum).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Pelodictyon.
OX   NCBI_TaxID=319225;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 273 / BCRC 81028 / 2530;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Pelodictyon luteolum DSM 273.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non-canonical ABC transporter that contains transmembrane
CC       domains (TMD), which form a pore in the inner membrane, and an ATP-
CC       binding domain (NBD), which is responsible for energy generation.
CC       Confers resistance against macrolides. {ECO:0000255|HAMAP-
CC       Rule:MF_01720}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01720}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01720}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01720}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Macrolide
CC       exporter (TC 3.A.1.122) family. {ECO:0000255|HAMAP-Rule:MF_01720}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABB23384.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP000096; ABB23384.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041464005.1; NC_007512.1.
DR   AlphaFoldDB; Q3B5J7; -.
DR   SMR; Q3B5J7; -.
DR   STRING; 319225.Plut_0496; -.
DR   EnsemblBacteria; ABB23384; ABB23384; Plut_0496.
DR   KEGG; plt:Plut_0496; -.
DR   eggNOG; COG0577; Bacteria.
DR   eggNOG; COG1136; Bacteria.
DR   HOGENOM; CLU_000604_78_2_10; -.
DR   Proteomes; UP000002709; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR017911; MacB_ATP-bd.
DR   InterPro; IPR025857; MacB_PCD.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF12704; MacB_PCD; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51267; MACB; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; ATP-binding; Cell inner membrane; Cell membrane;
KW   Membrane; Nucleotide-binding; Translocase; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..664
FT                   /note="Macrolide export ATP-binding/permease protein MacB"
FT                   /id="PRO_0000269954"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        543..563
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        602..622
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        627..647
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   DOMAIN          8..245
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   BINDING         44..51
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
SQ   SEQUENCE   664 AA;  72260 MW;  5BE044393EE7AE0B CRC64;
     MAPTTPLLEL VDVHRTYPVG ESTVNALRGV SLEIREGEFV AIMGSSGSGK SSLLHILGLL
     DNPDRGEYRI LGRNVNALPE DGQAGLRNHV AGFVFQQFHL LKRMSIVDNV RLPHIYSGLK
     GDFRHEALES LKKVGLMHRL DHTPGQLSGG EQQRVAIARA LIGNPMILFA DEPTGNLDSR
     NSLEIMKILE ELHREGRTIV MVTHEDEIAA YADRVITMRD GLVVSDQRRD RVCLPAGPSV
     PLTLDPHAMM DASRNLSVWQ DGRFIGFVQQ AFQSIFANKV RSLLSVLGIL VGVASVIAMM
     ALGEGAKVSI EEELKSMGSN LISVRGGSAR VRGAAQGDGA VARFTFKDVK DISRMHSLVK
     GAAGTVNGSG QIVFGNRNWS TTLDGVGYEY GSMRAFVPSI GRWFTRDEIR KREKVAVIGV
     TVARELFGNN NPIGHTVKIN RINFKVIGIA PAKGFSTHRD QDDVVLVPVT TAMYRVLGRD
     YLNSIYVEVR SAEGIDGAKE AVSDLIVKNH RLREGDDSFN IRDMTEIQEM LSSTTRTMSM
     LLGAIAAISL LVGGIGIMNI MLVSVTERTR EIGLRKAIGA RREDIMLQFL VESVGLTLSG
     GIIGIIAGIG ISALLAVFAG WAVKTSIVSI VLATFFSAIT GIFFGLWPAR KAAELRPVEA
     LRYE