ID   MACB_RHORT              Reviewed;         650 AA.
AC   Q2RPB4;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Macrolide export ATP-binding/permease protein MacB {ECO:0000255|HAMAP-Rule:MF_01720};
DE            EC=7.6.2.- {ECO:0000255|HAMAP-Rule:MF_01720};
GN   Name=macB {ECO:0000255|HAMAP-Rule:MF_01720}; OrderedLocusNames=Rru_A3236;
OS   Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 /
OS   NCIMB 8255 / S1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Rhodospirillum.
OX   NCBI_TaxID=269796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1;
RX   PubMed=21886856; DOI=10.4056/sigs.1804360;
RA   Munk A.C., Copeland A., Lucas S., Lapidus A., Del Rio T.G., Barry K.,
RA   Detter J.C., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D.,
RA   Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Kyrpides N.C.,
RA   Mavromatis K., Richardson P., Rohde M., Goeker M., Klenk H.P., Zhang Y.,
RA   Roberts G.P., Reslewic S., Schwartz D.C.;
RT   "Complete genome sequence of Rhodospirillum rubrum type strain (S1).";
RL   Stand. Genomic Sci. 4:293-302(2011).
CC   -!- FUNCTION: Non-canonical ABC transporter that contains transmembrane
CC       domains (TMD), which form a pore in the inner membrane, and an ATP-
CC       binding domain (NBD), which is responsible for energy generation.
CC       Confers resistance against macrolides. {ECO:0000255|HAMAP-
CC       Rule:MF_01720}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01720}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01720}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01720}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Macrolide
CC       exporter (TC 3.A.1.122) family. {ECO:0000255|HAMAP-Rule:MF_01720}.
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DR   EMBL; CP000230; ABC24031.1; -; Genomic_DNA.
DR   RefSeq; WP_011390984.1; NC_007643.1.
DR   RefSeq; YP_428318.1; NC_007643.1.
DR   AlphaFoldDB; Q2RPB4; -.
DR   SMR; Q2RPB4; -.
DR   STRING; 269796.Rru_A3236; -.
DR   EnsemblBacteria; ABC24031; ABC24031; Rru_A3236.
DR   KEGG; rru:Rru_A3236; -.
DR   PATRIC; fig|269796.9.peg.3351; -.
DR   eggNOG; COG0577; Bacteria.
DR   eggNOG; COG1136; Bacteria.
DR   HOGENOM; CLU_000604_78_2_5; -.
DR   OMA; VVILITH; -.
DR   OrthoDB; 1181903at2; -.
DR   PhylomeDB; Q2RPB4; -.
DR   Proteomes; UP000001929; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR017911; MacB_ATP-bd.
DR   InterPro; IPR025857; MacB_PCD.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF12704; MacB_PCD; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51267; MACB; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; ATP-binding; Cell inner membrane; Cell membrane;
KW   Membrane; Nucleotide-binding; Reference proteome; Translocase;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..650
FT                   /note="Macrolide export ATP-binding/permease protein MacB"
FT                   /id="PRO_0000269973"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        525..545
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        580..600
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   TRANSMEM        615..635
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   DOMAIN          9..248
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
FT   BINDING         45..52
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01720"
SQ   SEQUENCE   650 AA;  68262 MW;  1A6F7DEA7A3B23A4 CRC64;
     MADTPPPLIE LIDLERVFDS SEVPVRALDR VSLTIHEGEF VAIIGQSGSG KSTLMSILGC
     LDRPTGGLYR LGGIDVASLD PVALAGLRRD TFGFVFQRYN LLAGASAAEN VEMPAVYAGQ
     PRHQRLERAH ALLDRLGMGA RSGHFPNQLS GGQQQRVSIA RALMNDPRVI LADEPTGALD
     SASGRDVLAL LEALHTEGRT VILITHDRDV AARAERVIAL QDGRVVEDSG RPAPVGSDRP
     LGRPPGGAAY LGMAASFGEA LKMAGRSLRA NIFRTALTLL GVVIGVAAVV TMMAIGEGSK
     QDVLTRIQSM GTNLLLVRPG APGIRPSGTD VSLTPTDAEA VAQLAGMAAV APERMASGIT
     VRREGIDYRT TINGTWPAYA AAKDWPMAWG SFFDATDLQA SAPVAVLGQT VAKNLFPGEE
     DPVGSYFLVR NVPFLVIGVL EAKGATPFGQ DQDDIVLIPL TTAFARVSGG RYLSSLTARV
     EDATTIDESQ AAIESLLQAR HGKVDFQVRN TQSLLEMVEK TQNSLTLLLG AVALISLLVG
     GIGVMNIMLV SVTERTREIG IRLATGARAS DILLQFNTEA VAVCGVGGLA GVGLGLGAAL
     AVAEFGLPVR FTPGPPIVAF CCAFLTGLLF GYLPARKAAR LDPVVALSAE