ID   MACC1_PONAB             Reviewed;         854 AA.
AC   Q5RBY8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Metastasis-associated in colon cancer protein 1;
DE   AltName: Full=SH3 domain-containing protein 7a5;
GN   Name=MACC1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcription activator for MET and as a key
CC       regulator of HGF-MET signaling. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with FASLG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR   EMBL; CR858494; CAH90722.1; -; mRNA.
DR   AlphaFoldDB; Q5RBY8; -.
DR   STRING; 9601.ENSPPYP00000019895; -.
DR   eggNOG; ENOG502QZDM; Eukaryota.
DR   InParanoid; Q5RBY8; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR000906; ZU5_dom.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS51145; ZU5; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome;
KW   SH3 domain; Transcription; Transcription regulation.
FT   CHAIN           1..854
FT                   /note="Metastasis-associated in colon cancer protein 1"
FT                   /id="PRO_0000329033"
FT   DOMAIN          212..349
FT                   /note="ZU5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00485"
FT   DOMAIN          549..619
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   MOD_RES         19
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6ZN28"
SQ   SEQUENCE   854 AA;  97087 MW;  F4CE15B2C04BAFB7 CRC64;
     MLITERKYFW SGRIAQSRSE ANLVDMEAGK LSKSCNITEC QDPDLLHNWP DAFTLHGNNA
     SKVTNPFWNQ LSASNPFLDD ITQLRNNRKR NNISILKEDP LLFFREIENG NSFDSSGDEL
     DVHQLLRQSS SRKSGRSKSV SELLDILDDT AHAHQSIHNS DQILLHDLEW LKNDREAYKM
     AWLSQRQLAR SCLDLNTISQ SPGWAQTQLA EVTKACKVNH QGGSVQLPES DITVHVPQGH
     VAVGEFQEVS LRAFLDPPHM LNHDLSCTVS PLLEIMLGNL NTMEALLLEM KIGAEVGKDP
     FSQVMTEMVC LHSLGKEGPF KILSNCYIYK DTIQVKLIDL SQVMYLVVAA QAKALQSPAA
     TIWDYIHKTT SIGIYGPKYI HPSFTVVLTV CGHNYMPGQL TISDIKKCGK NISPVVFQLW
     GKQSFLLDKP QDLSISIFSC DPDFEVKTEG ERKEIKQKQL EAGEVVHQQF LFSLVEHREM
     HLFDFCVQVE LPNGEPVAQF CITTPDPTPN LKRLSNLPGY LQKKEEIKSA PLSPKILVKY
     PTFQDKTLNF TNYGVTLKAV LRQSKIDYFL EYFKGDTIAL LGEGKVKVIG QSKVKEWYVG
     VLRGKIGLVH CKNVKVISKE QVMFMSDSVF TTRNLLEQIV LPLKKLTYIY SVVLTLVSEK
     VYDWKVLADV LGYSHLSVED FDQIHADKES EKVSYVIKKL KEDCHTKRNT RKFLYELIVA
     LLKMDCQALV ARLIREAAVL TSAVKLGKGW RELAEKLVRL TKQQMEAYEI PHRGNTGDVA
     VEMMWKPAYD FLYTWSAHYG NNYRDVLQDL QSALDRMKNP VTKHWRELTG VLILVNSLEV
     LRVTAFSTSE EVWK