ID   MACIR_BOVIN             Reviewed;         207 AA.
AC   Q3ZBS1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Macrophage immunometabolism regulator;
GN   Name=MACIR;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates the macrophage function, by enhancing the
CC       resolution of inflammation and wound repair functions mediated by M2
CC       macrophages. The regulation of macrophage function is, due at least in
CC       part, to its ability to inhibit glycolysis. May play also a role in
CC       trafficking of proteins via its interaction with UNC119 and UNC119B
CC       cargo adapters: may help the release of UNC119 and UNC119B cargo or the
CC       recycling of UNC119 and UNC119B. May play a role in ciliary membrane
CC       localization via its interaction with UNC119B and protein transport
CC       into photoreceptor cells. {ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SUBUNIT: Interacts with UNC119 and UNC119B; interaction preferentially
CC       takes place when UNC119 and UNC119B are unliganded with myristoylated
CC       proteins. {ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96GV9}. Cell
CC       projection, cilium {ECO:0000250|UniProtKB:Q96GV9}. Note=Localizes to
CC       the transition zone and proximal cilium in addition to being found
CC       throughout the cytoplasm. {ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SIMILARITY: Belongs to the UNC119-binding protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC103141; AAI03142.1; -; mRNA.
DR   RefSeq; NP_001069596.1; NM_001076128.1.
DR   AlphaFoldDB; Q3ZBS1; -.
DR   STRING; 9913.ENSBTAP00000055335; -.
DR   PaxDb; Q3ZBS1; -.
DR   PRIDE; Q3ZBS1; -.
DR   Ensembl; ENSBTAT00000083647; ENSBTAP00000063573; ENSBTAG00000055286.
DR   GeneID; 538782; -.
DR   KEGG; bta:538782; -.
DR   CTD; 90355; -.
DR   VEuPathDB; HostDB:ENSBTAG00000055286; -.
DR   VGNC; VGNC:52734; MACIR.
DR   eggNOG; ENOG502QRGS; Eukaryota.
DR   GeneTree; ENSGT00390000005782; -.
DR   HOGENOM; CLU_082309_0_0_1; -.
DR   InParanoid; Q3ZBS1; -.
DR   OMA; LHMNSNY; -.
DR   OrthoDB; 1190422at2759; -.
DR   TreeFam; TF331553; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000055286; Expressed in occipital lobe and 104 other tissues.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR029219; UNC119-bd.
DR   PANTHER; PTHR31224; PTHR31224; 1.
DR   Pfam; PF15435; UNC119_bdg; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Cytoplasm; Inflammatory response; Phosphoprotein; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..207
FT                   /note="Macrophage immunometabolism regulator"
FT                   /id="PRO_0000316775"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GV9"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GV9"
FT   MOD_RES         140
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GV9"
FT   MOD_RES         167
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GV9"
SQ   SEQUENCE   207 AA;  23130 MW;  507864160D8D1F1F CRC64;
     MEVDVNGESR SALTTLPLPV AEASSPGKAE AEKPRCSSTP CSPMRRTVSG YQILHMDSNY
     LVGFTTGEEL LKLAQKCTGA EESKGEAVPS LRSKQLDVGL ARSSRLYKTR SRYYQPYEIP
     AVNGRRRRRM PSSGDKCTKS LPYEPYKALH GPLPLCLLKG KRAHSKSLDY LNLDKMNIKE
     PADTEVLQYQ LQHLTLRGDR VFARNNT