ID   MACIR_DANRE             Reviewed;         206 AA.
AC   B3DHS1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Macrophage immunometabolism regulator;
GN   Name=macir; ORFNames=zgc:194273, zgc:194281;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=22085962; DOI=10.1101/gad.173443.111;
RA   Wright K.J., Baye L.M., Olivier-Mason A., Mukhopadhyay S., Sang L.,
RA   Kwong M., Wang W., Pretorius P.R., Sheffield V.C., Sengupta P.,
RA   Slusarski D.C., Jackson P.K.;
RT   "An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary
RT   cilium.";
RL   Genes Dev. 25:2347-2360(2011).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=30659109; DOI=10.4049/jimmunol.1801155;
RA   Dorris E.R., Tazzyman S.J., Moylett J., Ramamoorthi N., Hackney J.,
RA   Townsend M., Muthana M., Lewis M.J., Pitzalis C., Wilson A.G.;
RT   "The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated
RT   Resolution of Inflammation.";
RL   J. Immunol. 202:1069-1078(2019).
CC   -!- FUNCTION: May play a role in immune regulation through regulation of
CC       the macrophage function (By similarity). Involved in the recruitment of
CC       macrophages in response to injury (PubMed:30659109). May also play a
CC       role in trafficking of proteins via its interaction with unc119 family
CC       cargo adapters (By similarity). May play a role in ciliary membrane
CC       localization (PubMed:22085962). {ECO:0000250|UniProtKB:Q96GV9,
CC       ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:30659109}.
CC   -!- FUNCTION: Regulates the macrophage function, by enhancing the
CC       resolution of inflammation and wound repair functions mediated by M2
CC       macrophages. The regulation of macrophage function is, due at least in
CC       part, to the role of C5orf30 in regulating ability to inhibit
CC       glycolysis. Probably plays alaso a role in trafficking of proteins via
CC       its interaction with UNC119 and UNC119B cargo adapters: may help the
CC       release of UNC119 and UNC119B cargo or the recycling of UNC119 and
CC       UNC119B. May play a role in ciliary membrane localization via its
CC       interaction with UNC119B and protein transport into photoreceptor
CC       cells. {ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SUBUNIT: Interacts with unc119 family proteins; interaction
CC       preferentially takes place when unc119 proteins are unliganded with
CC       myristoylated proteins. {ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96GV9}. Cell
CC       projection, cilium {ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown increases the recruitment of
CC       macrophages in response to injury. {ECO:0000269|PubMed:30659109}.
CC   -!- SIMILARITY: Belongs to the UNC119-binding protein family.
CC       {ECO:0000305}.
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DR   EMBL; BC162867; AAI62867.1; -; mRNA.
DR   EMBL; BC162875; AAI62875.1; -; mRNA.
DR   RefSeq; NP_001122229.1; NM_001128757.1.
DR   AlphaFoldDB; B3DHS1; -.
DR   STRING; 7955.ENSDARP00000098404; -.
DR   PaxDb; B3DHS1; -.
DR   Ensembl; ENSDART00000110735; ENSDARP00000098404; ENSDARG00000093498.
DR   GeneID; 570279; -.
DR   KEGG; dre:570279; -.
DR   CTD; 90355; -.
DR   ZFIN; ZDB-GENE-081022-94; macir.
DR   eggNOG; ENOG502QRGS; Eukaryota.
DR   GeneTree; ENSGT00390000005782; -.
DR   HOGENOM; CLU_082309_0_0_1; -.
DR   InParanoid; B3DHS1; -.
DR   OMA; LHMNSNY; -.
DR   OrthoDB; 1190422at2759; -.
DR   PhylomeDB; B3DHS1; -.
DR   TreeFam; TF331553; -.
DR   PRO; PR:B3DHS1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000093498; Expressed in retina and 15 other tissues.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0070121; P:Kupffer's vesicle development; IMP:ZFIN.
DR   GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IBA:GO_Central.
DR   GO; GO:0010764; P:negative regulation of fibroblast migration; IBA:GO_Central.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR   GO; GO:0010760; P:negative regulation of macrophage chemotaxis; IMP:ZFIN.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:1905521; P:regulation of macrophage migration; IMP:UniProtKB.
DR   GO; GO:0061041; P:regulation of wound healing; IMP:ZFIN.
DR   InterPro; IPR029219; UNC119-bd.
DR   PANTHER; PTHR31224; PTHR31224; 1.
DR   Pfam; PF15435; UNC119_bdg; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Inflammatory response; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..206
FT                   /note="Macrophage immunometabolism regulator"
FT                   /id="PRO_0000359747"
SQ   SEQUENCE   206 AA;  22904 MW;  E74E1381E9A79C71 CRC64;
     MEMDASGASR APISVLPAAE VKSTLKPEAD KPRCSSTPCS PIKSTVSGYQ ILHMNSNYLV
     GFTTGEELLK LAQKWSSPDS SNTEALPSPI KKPVDLGLHR ASRIYKAKSR YYQPYDIPAV
     NGRRRRRMPS SGDSCLKSIV SGEPSKALHG PLPLCLLKGK RVYSKSLDYL NLDKMSLREP
     VDTEVLQYQL QHLNLRGERV FTRNKT