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MACIR_PONAB
ID   MACIR_PONAB             Reviewed;         206 AA.
AC   Q5RDK8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Macrophage immunometabolism regulator;
GN   Name=MACIR;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates the macrophage function, by enhancing the
CC       resolution of inflammation and wound repair functions mediated by M2
CC       macrophages. The regulation of macrophage function is, due at least in
CC       part, to its ability to inhibit glycolysis. May also play a role in
CC       trafficking of proteins via its interaction with UNC119 and UNC119B
CC       cargo adapters: may help the release of UNC119 and UNC119B cargo or the
CC       recycling of UNC119 and UNC119B. May play a role in ciliary membrane
CC       localization via its interaction with UNC119B and protein transport
CC       into photoreceptor cells. {ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SUBUNIT: Interacts with UNC119 and UNC119B; interaction preferentially
CC       takes place when UNC119 and UNC119B are unliganded with myristoylated
CC       proteins. {ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96GV9}. Cell
CC       projection, cilium {ECO:0000250|UniProtKB:Q96GV9}. Note=Localizes to
CC       the transition zone and proximal cilium in addition to being found
CC       throughout the cytoplasm. {ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SIMILARITY: Belongs to the UNC119-binding protein family.
CC       {ECO:0000305}.
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DR   EMBL; CR857897; CAH90149.1; -; mRNA.
DR   RefSeq; NP_001125041.1; NM_001131569.1.
DR   AlphaFoldDB; Q5RDK8; -.
DR   STRING; 9601.ENSPPYP00000017520; -.
DR   GeneID; 100171922; -.
DR   KEGG; pon:100171922; -.
DR   CTD; 90355; -.
DR   eggNOG; ENOG502QRGS; Eukaryota.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR029219; UNC119-bd.
DR   PANTHER; PTHR31224; PTHR31224; 1.
DR   Pfam; PF15435; UNC119_bdg; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Cytoplasm; Inflammatory response; Phosphoprotein; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..206
FT                   /note="Macrophage immunometabolism regulator"
FT                   /id="PRO_0000316778"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GV9"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GV9"
FT   MOD_RES         140
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GV9"
FT   MOD_RES         167
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GV9"
SQ   SEQUENCE   206 AA;  23025 MW;  5E9DD27AC5CA7A85 CRC64;
     MEVDINGESR STLTTLPFPG AEANSPGKAE AEKPRCSSTP CSPMRRTVSG YQILHMDSNY
     LVGFTTGEEL LKLAQKCTGG EESKAEAMPS LRSKQLDAGL ARSSRLYKTR SRYYQPYEIP
     AVNGRRRRRM PSSGDKCTKS LPYEPYKALH GPLPLCLLKG KRAHSKSLDY LNLDKMIKEP
     ADTEVLQYQL QHLTLRGGRV FARNNT
 
 
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