MACIR_PONAB
ID MACIR_PONAB Reviewed; 206 AA.
AC Q5RDK8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Macrophage immunometabolism regulator;
GN Name=MACIR;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates the macrophage function, by enhancing the
CC resolution of inflammation and wound repair functions mediated by M2
CC macrophages. The regulation of macrophage function is, due at least in
CC part, to its ability to inhibit glycolysis. May also play a role in
CC trafficking of proteins via its interaction with UNC119 and UNC119B
CC cargo adapters: may help the release of UNC119 and UNC119B cargo or the
CC recycling of UNC119 and UNC119B. May play a role in ciliary membrane
CC localization via its interaction with UNC119B and protein transport
CC into photoreceptor cells. {ECO:0000250|UniProtKB:Q96GV9}.
CC -!- SUBUNIT: Interacts with UNC119 and UNC119B; interaction preferentially
CC takes place when UNC119 and UNC119B are unliganded with myristoylated
CC proteins. {ECO:0000250|UniProtKB:Q96GV9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96GV9}. Cell
CC projection, cilium {ECO:0000250|UniProtKB:Q96GV9}. Note=Localizes to
CC the transition zone and proximal cilium in addition to being found
CC throughout the cytoplasm. {ECO:0000250|UniProtKB:Q96GV9}.
CC -!- SIMILARITY: Belongs to the UNC119-binding protein family.
CC {ECO:0000305}.
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DR EMBL; CR857897; CAH90149.1; -; mRNA.
DR RefSeq; NP_001125041.1; NM_001131569.1.
DR AlphaFoldDB; Q5RDK8; -.
DR STRING; 9601.ENSPPYP00000017520; -.
DR GeneID; 100171922; -.
DR KEGG; pon:100171922; -.
DR CTD; 90355; -.
DR eggNOG; ENOG502QRGS; Eukaryota.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR029219; UNC119-bd.
DR PANTHER; PTHR31224; PTHR31224; 1.
DR Pfam; PF15435; UNC119_bdg; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell projection; Cilium; Cilium biogenesis/degradation;
KW Cytoplasm; Inflammatory response; Phosphoprotein; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..206
FT /note="Macrophage immunometabolism regulator"
FT /id="PRO_0000316778"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q96GV9"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96GV9"
FT MOD_RES 140
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96GV9"
FT MOD_RES 167
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96GV9"
SQ SEQUENCE 206 AA; 23025 MW; 5E9DD27AC5CA7A85 CRC64;
MEVDINGESR STLTTLPFPG AEANSPGKAE AEKPRCSSTP CSPMRRTVSG YQILHMDSNY
LVGFTTGEEL LKLAQKCTGG EESKAEAMPS LRSKQLDAGL ARSSRLYKTR SRYYQPYEIP
AVNGRRRRRM PSSGDKCTKS LPYEPYKALH GPLPLCLLKG KRAHSKSLDY LNLDKMIKEP
ADTEVLQYQL QHLTLRGGRV FARNNT