ID   MACIR_XENLA             Reviewed;         205 AA.
AC   Q6DFB0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Macrophage immunometabolism regulator;
GN   Name=macir;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in immune regulation through regulation of
CC       the macrophage function (By similarity). May also play a role in
CC       trafficking of proteins via its interaction with unc119 family cargo
CC       adapters (By similarity). May play a role in ciliary membrane
CC       localization (By similarity). {ECO:0000250|UniProtKB:B3DHS1,
CC       ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SUBUNIT: Interacts with unc119 family proteins; interaction
CC       preferentially takes place when unc119 proteins are unliganded with
CC       myristoylated proteins. {ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96GV9}. Cell
CC       projection, cilium {ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SIMILARITY: Belongs to the UNC119-binding protein family.
CC       {ECO:0000305}.
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DR   EMBL; BC076830; AAH76830.1; -; mRNA.
DR   RefSeq; NP_001086578.1; NM_001093109.1.
DR   AlphaFoldDB; Q6DFB0; -.
DR   DNASU; 446413; -.
DR   GeneID; 446413; -.
DR   KEGG; xla:446413; -.
DR   CTD; 446413; -.
DR   Xenbase; XB-GENE-942418; macir.L.
DR   OMA; CNKAVPY; -.
DR   OrthoDB; 1190422at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 446413; Expressed in blastula and 15 other tissues.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR029219; UNC119-bd.
DR   PANTHER; PTHR31224; PTHR31224; 1.
DR   Pfam; PF15435; UNC119_bdg; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Inflammatory response; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..205
FT                   /note="Macrophage immunometabolism regulator"
FT                   /id="PRO_0000316779"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   205 AA;  22780 MW;  95D21710E38C5D74 CRC64;
     MEVDINGVNR TNNSVPSTAE GSSPSKPDPE KPRCSSTPCS PIRRTVSGYQ ILHMDANFLV
     GFTTGGELLK LAQKCATTEE TPGESLPAFR SKQLESGLSR SSRIYKARGR QFQPYDIPAV
     NGRRRRRMPS SGDKCNKAVP YEPYKAAHGP LPLCLLKGKR AHSKSLDYLN LDKMNIKESA
     DTEVLQYQLQ HLTLRGDRVF ARNNT