ID   MACIR_XENTR             Reviewed;         205 AA.
AC   A4IGV6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Macrophage immunometabolism regulator;
GN   Name=macir;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in immune regulation through regulation of
CC       the macrophage function (By similarity). May also play a role in
CC       trafficking of proteins via its interaction with unc119 family cargo
CC       adapters (By similarity). May play a role in ciliary membrane
CC       localization (By similarity). {ECO:0000250|UniProtKB:B3DHS1,
CC       ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SUBUNIT: Interacts with unc119 family proteins; interaction
CC       preferentially takes place when unc119 proteins are unliganded with
CC       myristoylated proteins. {ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96GV9}. Cell
CC       projection, cilium {ECO:0000250|UniProtKB:Q96GV9}.
CC   -!- SIMILARITY: Belongs to the UNC119-binding protein family.
CC       {ECO:0000305}.
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DR   EMBL; BC135262; AAI35263.1; -; mRNA.
DR   RefSeq; NP_001090814.1; NM_001097345.1.
DR   RefSeq; XP_012813388.1; XM_012957934.2.
DR   AlphaFoldDB; A4IGV6; -.
DR   STRING; 8364.ENSXETP00000051427; -.
DR   PaxDb; A4IGV6; -.
DR   DNASU; 100037912; -.
DR   Ensembl; ENSXETT00000051427; ENSXETP00000051427; ENSXETG00000023861.
DR   GeneID; 100037912; -.
DR   KEGG; xtr:100037912; -.
DR   CTD; 90355; -.
DR   Xenbase; XB-GENE-942413; macir.
DR   eggNOG; ENOG502QRGS; Eukaryota.
DR   HOGENOM; CLU_082309_0_0_1; -.
DR   InParanoid; A4IGV6; -.
DR   OMA; CNKAVPY; -.
DR   OrthoDB; 1190422at2759; -.
DR   PhylomeDB; A4IGV6; -.
DR   TreeFam; TF331553; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023861; Expressed in brain and 13 other tissues.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IBA:GO_Central.
DR   GO; GO:0010764; P:negative regulation of fibroblast migration; IBA:GO_Central.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR029219; UNC119-bd.
DR   PANTHER; PTHR31224; PTHR31224; 1.
DR   Pfam; PF15435; UNC119_bdg; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Inflammatory response; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..205
FT                   /note="Macrophage immunometabolism regulator"
FT                   /id="PRO_0000316780"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   205 AA;  22962 MW;  0DF757F451F75A2E CRC64;
     MEVDINGVNR TNNSVPSTTE GSSPSKPDPE KPRCSSTPCS PIRRTVSGYQ ILHMDANFLV
     GFTTGEELLK LAHKCATTEE NPGESLPAFR SKQLESGLSR SSRIYKARGR QYQPYEIPAV
     NGRRRRRMPS SGDKCNKAVP YEPYKAVHGP LPLCLLKGKR AHSKSLDYLN LDKMNIKESA
     DTEVLQYQLQ HLTLRGDRVF ARNNT