MACOI_RAT
ID MACOI_RAT Reviewed; 664 AA.
AC Q4V7D3; Q2TLZ0;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Macoilin;
DE AltName: Full=Macoilin-1;
DE AltName: Full=Transmembrane protein 57;
GN Name=Maco1 {ECO:0000312|RGD:1561685}; Synonyms=Tmem57;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Huang C.-H., Chen Y.;
RT "Identification of macoilin as a novel membrane-associated coiled-coil
RT tetraspanin protein.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Plays a role in the regulation of neuronal activity.
CC {ECO:0000250|UniProtKB:Q8N5G2}.
CC -!- SUBCELLULAR LOCATION: Rough endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P91193}; Multi-pass membrane protein
CC {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:P91193}; Multi-
CC pass membrane protein {ECO:0000255}. Note=Detected in the nucleus
CC membrane of non-neuronal cells and in axonal outgrowths of neuronal
CC cells. {ECO:0000250|UniProtKB:Q7TQE6}.
CC -!- SIMILARITY: Belongs to the macoilin family. {ECO:0000305}.
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DR EMBL; AY845021; AAX11919.1; -; mRNA.
DR EMBL; BC097999; AAH97999.1; -; mRNA.
DR RefSeq; NP_001020870.2; NM_001025699.2.
DR AlphaFoldDB; Q4V7D3; -.
DR SMR; Q4V7D3; -.
DR STRING; 10116.ENSRNOP00000029925; -.
DR GlyGen; Q4V7D3; 4 sites.
DR iPTMnet; Q4V7D3; -.
DR PhosphoSitePlus; Q4V7D3; -.
DR PaxDb; Q4V7D3; -.
DR PRIDE; Q4V7D3; -.
DR Ensembl; ENSRNOT00000079536; ENSRNOP00000069310; ENSRNOG00000056156.
DR GeneID; 313618; -.
DR KEGG; rno:313618; -.
DR CTD; 55219; -.
DR RGD; 1561685; Maco1.
DR eggNOG; KOG1821; Eukaryota.
DR GeneTree; ENSGT00390000016613; -.
DR HOGENOM; CLU_012823_1_0_1; -.
DR InParanoid; Q4V7D3; -.
DR OMA; KIHEMEY; -.
DR OrthoDB; 1227984at2759; -.
DR PhylomeDB; Q4V7D3; -.
DR Reactome; R-RNO-8980692; RHOA GTPase cycle.
DR Reactome; R-RNO-9013106; RHOC GTPase cycle.
DR PRO; PR:Q4V7D3; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000056156; Expressed in testis and 19 other tissues.
DR Genevisible; Q4V7D3; RN.
DR GO; GO:0030424; C:axon; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; ISO:RGD.
DR GO; GO:0044306; C:neuron projection terminus; ISO:RGD.
DR GO; GO:0031965; C:nuclear membrane; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0045202; C:synapse; ISO:RGD.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; ISO:RGD.
DR GO; GO:0006935; P:chemotaxis; IBA:GO_Central.
DR GO; GO:0023041; P:neuronal signal transduction; ISS:UniProtKB.
DR InterPro; IPR019130; Macoilin.
DR PANTHER; PTHR47464:SF3; PTHR47464:SF3; 1.
DR Pfam; PF09726; Macoilin; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Nucleus; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..664
FT /note="Macoilin"
FT /id="PRO_0000070271"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 252..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 305
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N5G2"
FT MOD_RES 332
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N5G2"
FT MOD_RES 631
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N5G2"
FT MOD_RES 634
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N5G2"
FT CARBOHYD 324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 340
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 452
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 655
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 301
FT /note="D -> V (in Ref. 1; AAX11919)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 664 AA; 76082 MW; EFF1DDCB58A8BD33 CRC64;
MKRRNADCSK LRRPLKRNRI TEGIYGSTFL YLKFLVVWAL VLLADFVLEF RFEYLWPFWL
FIRSVYDSFR YQGLAFSVFF VCVAFTSNII CLLFIPIQWL FFAASTYVWV QYVWHTERGV
CLPTVSLWIL FVYIEAAIRF KDLKNFHVDL CRPFAAHCIG YPVVTLGFGF KSYVSYKMRL
RKQKEVQKEN EFYMQLLQQA LPPEQQMLQK QEKEAEEAAK GLPDMDSSIL IHHNGGIPAN
KKLSTALPEI EYREKGKEKD KDAKKHNLGI NNNNILQPVD SKIQEIEYME NHINSKRLNN
DLVGSTENLL KEDSCTASSK NYKNASGVVN SSPRSHSATN GSIPSSSSKN EKKQRCTSKG
PSAHKDLMEN CIPNNQLSKP DALVRLEQDI KKLKADLQAS RQVEQELRSQ ISSLSSTERG
IRSEMGQLRQ ENELLQNKLH NAVQMKQKDK QNISQLEKRL KAEQEARGFV EKQLMEEKKR
KKLEEATAAR AVAFAAASRG ECTETLRSRI RELEAEGKKL TMDLKVKEEQ IRELELKVQE
LRKYKENEKD TEVLMSALSA MQDKTQHLEN SLSAETRIKL DLFSALGDAK RQLEIAQGQI
LQKDQEIKDL KQKIAEVMAV MPSITYSAAT SPLSPVSPHY SSKFVETSPS GLDPNASVYQ
PLKK
