ID   MACR_PENTR              Reviewed;         853 AA.
AC   A0A2P1DP89;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2018, sequence version 1.
DT   03-AUG-2022, entry version 17.
DE   RecName: Full=Transcription factor macR {ECO:0000303|PubMed:28926261};
DE   AltName: Full=Macrophorins biosynthesis cluster protein R {ECO:0000303|PubMed:28926261};
GN   Name=macR {ECO:0000303|PubMed:28926261};
OS   Penicillium terrestre.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=374132;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND PATHWAY.
RC   STRAIN=LM2;
RX   PubMed=28926261; DOI=10.1021/acs.orglett.7b02653;
RA   Tang M.C., Cui X., He X., Ding Z., Zhu T., Tang Y., Li D.;
RT   "Late-stage terpene cyclization by an integral membrane cyclase in the
RT   biosynthesis of isoprenoid epoxycyclohexenone natural products.";
RL   Org. Lett. 19:5376-5379(2017).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of macrophorins, isoprenoid
CC       epoxycyclohexenones containing cyclized drimane moieties.
CC       {ECO:0000269|PubMed:28926261}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- MISCELLANEOUS: The macrophorins cluster contains a single gene
CC       insertion (encoding for the terpene cyclase macJ) compared with the
CC       yanuthone cluster that produces the linear compound yanuthone.
CC       {ECO:0000269|PubMed:28926261}.
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DR   EMBL; MF989995; AVK70096.1; -; Genomic_DNA.
DR   EMBL; MH388470; QBC75452.1; -; Genomic_DNA.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..853
FT                   /note="Transcription factor macR"
FT                   /id="PRO_0000454093"
FT   DNA_BIND        18..45
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          54..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          734..775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          833..853
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..116
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..165
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        734..761
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   853 AA;  94426 MW;  CD64932694D4F64D CRC64;
     MPLSEPRQIK KPRLSLSCIV CRRRKVRCGR EQPECANCVR MKENCVYRTM VRDESTGRVR
     PVSPQDKDSR VSTSDARPDL PWPHWGRDTN APYPDKPSRP PSRPQVSANA SPSPQRQEPY
     PTVPSWEEAI QLPSYRDANA PQINGSSTTT RDPSPAPSTS LFPTPSDHPC RDYLSIRRGG
     RVRYVGQTFW GFVAGKESLS DDFFDENRHA HPDLPLPHIS SMGMFNLLRS LPTKPVSDTL
     LETFFLAVWP LVPLLHPPSL QADYDEFWEW CRNSENALPS DKLRDDPTLI CLLFAVLYCG
     ASAAPAATWA NTNLQGLQKE TTVSHLKSAY TTSLSLCQHQ EHPTLNTLVS NLLTGPFLDR
     PFEPMRSLVN VSTTVRIAQT MGLHREGAWS ALSSVDREIR RRVWWHIVWL DVQSSISTGL
     TPCCGNEALD AVGMVGTDHV EPSNIPAGLS PPNELVTNRQ SVAMLYAIGR FQTARLQARI
     VAHLQSAHDP SQDGFGELIT DSKELLQKID SLIARVPTQG IPEMGYIPSR LANASPSTQP
     LLYKDDPSQP TVFSAWTRIM LTLLKSEMAI LLQKPFLPPP DSANPQSLKS WTSMAQLCVN
     YLRIYLQLYQ APAFSPYAWF CCSHYGPLQC VFITLMYLHY FQHSGETTLA RYCVDEVIHH
     CVAQYQAPDP SSTRTSPDDT DSNGGKLRMP LAIQVLVDLH ERLDSSLGPE DRAPPLDLIE
     CQARFSMSHL ATKASDLRAT SDQPSSDVSS TTRTHHNCET PPITTGAPPV AAGNKPVPPN
     SVFVAGSDSG LDMDFLATIS DLEAWSSSLI LESDNLLARP DDMTPDHAVI TRLGSQSTAS
     GRRGLPDGLD FPG