MAD18_ORYSJ
ID MAD18_ORYSJ Reviewed; 249 AA.
AC Q0D4T4; B9FYB4; Q6Z4G0; Q9M7C5; Q9SEV1; Q9SMB3;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=MADS-box transcription factor 18;
DE AltName: Full=FDRMADS7;
DE AltName: Full=MADS-box protein 2;
DE AltName: Full=MADS-box protein 28;
DE AltName: Full=OsMADS18;
DE AltName: Full=OsMADS2;
DE AltName: Full=OsMADS28;
GN Name=MADS18; Synonyms=MADS2, MADS28;
GN OrderedLocusNames=Os07g0605200, LOC_Os07g41370;
GN ORFNames=OsJ_25046 {ECO:0000312|EMBL:EEE67551.1}, OSJNBb0040H10.26;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE, AND INTERACTION WITH MADS6.
RC TISSUE=Flower;
RX PubMed=10444103; DOI=10.1104/pp.120.4.1193;
RA Moon Y.-H., Kang H.-G., Jung J.-Y., Jeon J.-S., Sung S.-K., An G.;
RT "Determination of the motif responsible for interaction between the rice
RT APETALA1/AGAMOUS-LIKE9 family proteins using a yeast two-hybrid system.";
RL Plant Physiol. 120:1193-1204(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Arborio; TISSUE=Flower;
RA Colombo L.;
RT "MADS28 gene.";
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [7]
RP INTERACTION WITH NF-YB1, FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=11971906; DOI=10.1074/jbc.m202546200;
RA Masiero S., Imbriano C., Ravasio F., Favaro R., Pelucchi N., Gorla M.S.,
RA Mantovani R., Colombo L., Kater M.M.;
RT "Ternary complex formation between MADS-box transcription factors and the
RT histone fold protein NF-YB.";
RL J. Biol. Chem. 277:26429-26435(2002).
RN [8]
RP FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, AND INTERACTION WITH
RP MADS6; MADS7; MADS8 AND MADS47.
RX PubMed=15299121; DOI=10.1104/pp.104.045039;
RA Fornara F., Parenicova L., Falasca G., Pelucchi N., Masiero S.,
RA Ciannamea S., Lopez-Dee Z.P., Altamura M.M., Colombo L., Kater M.M.;
RT "Functional characterization of OsMADS18, a member of the AP1/SQUA
RT subfamily of MADS box genes.";
RL Plant Physiol. 135:2207-2219(2004).
CC -!- FUNCTION: Probable transcription factor that may promote floral
CC transition phase and differentiation program of the vegetative shoot.
CC {ECO:0000269|PubMed:11971906, ECO:0000269|PubMed:15299121}.
CC -!- SUBUNIT: Heterodimer or heterotrimer. Interacts with the K-box of
CC MADS6. Also able to interact directly with MADS7, MADS8 and MADS47. The
CC dimer composed of MADS18 and MADS6 forms a ternary complex with histone
CC fold protein NF-YB1. {ECO:0000269|PubMed:10444103,
CC ECO:0000269|PubMed:11971906, ECO:0000269|PubMed:15299121}.
CC -!- INTERACTION:
CC Q0D4T4; Q6EU39: MADS6; NbExp=3; IntAct=EBI-627967, EBI-627980;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Widely expressed. Transcripts accumulate to higher
CC levels in organs that retain meristematic characteristics: in the
CC apical meristem and in the meristematic leaf primordia formed on its
CC flank; in the developing panicle at the early stage of rachis-branch
CC primordia differentiation; in the procambium of the rachis branches and
CC in all floral organ primordia. {ECO:0000269|PubMed:11971906,
CC ECO:0000269|PubMed:15299121}.
CC -!- DEVELOPMENTAL STAGE: Not expressed at early stages of plant
CC development. First detected in leaves 4 weeks after germination, and
CC expression levels are increased when the plant reaches the reproductive
CC stage. {ECO:0000269|PubMed:15299121}.
CC -!- MISCELLANEOUS: Plants overexpressing MADS18 remain very small in size
CC and flower at 105 days after germination compared to wild-type plants
CC which flower at 140 days after germination.
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DR EMBL; AF091458; AAF04972.1; -; mRNA.
DR EMBL; AJ011675; CAB56800.1; -; mRNA.
DR EMBL; AP005175; BAC83880.1; -; Genomic_DNA.
DR EMBL; AP008213; BAF22139.1; -; Genomic_DNA.
DR EMBL; AP014963; BAT02559.1; -; Genomic_DNA.
DR EMBL; CM000144; EEE67551.1; -; Genomic_DNA.
DR RefSeq; XP_015647484.1; XM_015791998.1.
DR AlphaFoldDB; Q0D4T4; -.
DR SMR; Q0D4T4; -.
DR IntAct; Q0D4T4; 2.
DR STRING; 4530.OS07T0605200-01; -.
DR PaxDb; Q0D4T4; -.
DR PRIDE; Q0D4T4; -.
DR EnsemblPlants; Os07t0605200-01; Os07t0605200-01; Os07g0605200.
DR GeneID; 4343851; -.
DR Gramene; Os07t0605200-01; Os07t0605200-01; Os07g0605200.
DR KEGG; osa:4343851; -.
DR eggNOG; KOG0014; Eukaryota.
DR HOGENOM; CLU_053053_0_2_1; -.
DR InParanoid; Q0D4T4; -.
DR OMA; WGDEYGI; -.
DR OrthoDB; 1178730at2759; -.
DR Proteomes; UP000000763; Chromosome 7.
DR Proteomes; UP000007752; Chromosome 7.
DR Proteomes; UP000059680; Chromosome 7.
DR Genevisible; Q0D4T4; OS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00265; MADS_MEF2_like; 1.
DR Gene3D; 3.40.1810.10; -; 1.
DR InterPro; IPR033896; MADS_MEF2-like.
DR InterPro; IPR002487; TF_Kbox.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR Pfam; PF01486; K-box; 1.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SSF55455; 1.
DR PROSITE; PS51297; K_BOX; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; Differentiation; DNA-binding; Flowering;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..249
FT /note="MADS-box transcription factor 18"
FT /id="PRO_0000199502"
FT DOMAIN 1..61
FT /note="MADS-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT DOMAIN 88..179
FT /note="K-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00629"
FT REGION 184..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 122
FT /note="I -> T (in Ref. 1; AAF04972)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 28285 MW; 9B78618813BF0C08 CRC64;
MGRGPVQLRR IENKINRQVT FSKRRNGLLK KAHEISVLCD ADVALIVFST KGKLYEFSSH
SSMEGILERY QRYSFDERAV LEPNTEDQEN WGDEYGILKS KLDALQKSQR QLLGEQLDTL
TIKELQQLEH QLEYSLKHIR SKKNQLLFES ISELQKKEKS LKNQNNVLQK LMETEKEKNN
AIINTNREEQ NGATPSTSSP TPVTAPDPIP TTNNSQSQPR GSGESEAQPS PAQAGNSKLP
PWMLRTSHT
