ID   MAD1_CANAL              Reviewed;         696 AA.
AC   Q59PD6; A0A1D8PFF2;
DT   29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   29-OCT-2014, sequence version 2.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Spindle assembly checkpoint component MAD1 {ECO:0000305};
GN   Name=MAD1 {ECO:0000312|CGD:CAL0000199073};
GN   OrderedLocusNames=CAALFM_C112660WA;
GN   ORFNames=CaO19.13714 {ECO:0000312|CGD:CAL0000199073},
GN   CaO19.6357 {ECO:0000312|CGD:CAL0000199073};
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Central component of the spindle assembly checkpoint which is
CC       a feedback control that prevents cells with incompletely assembled
CC       spindles from leaving mitosis. {ECO:0000250|UniProtKB:P40957}.
CC   -!- SUBUNIT: Component of the mitotic checkpoint complex (MCC).
CC       {ECO:0000250|UniProtKB:P40957}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MAD1 family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW26881.1; -; Genomic_DNA.
DR   RefSeq; XP_711575.2; XM_706483.2.
DR   AlphaFoldDB; Q59PD6; -.
DR   SMR; Q59PD6; -.
DR   STRING; 237561.Q59PD6; -.
DR   PRIDE; Q59PD6; -.
DR   GeneID; 3646835; -.
DR   KEGG; cal:CAALFM_C112660WA; -.
DR   CGD; CAL0000199073; orf19.13714.
DR   VEuPathDB; FungiDB:C1_12660W_A; -.
DR   eggNOG; KOG4593; Eukaryota.
DR   HOGENOM; CLU_418026_0_0_1; -.
DR   InParanoid; Q59PD6; -.
DR   OMA; HHNYSTE; -.
DR   OrthoDB; 602490at2759; -.
DR   PRO; PR:Q59PD6; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR   GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IBA:GO_Central.
DR   InterPro; IPR008672; Mad1.
DR   PANTHER; PTHR23168; PTHR23168; 1.
DR   Pfam; PF05557; MAD; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..696
FT                   /note="Spindle assembly checkpoint component MAD1"
FT                   /id="PRO_0000430605"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          394..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..414
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   696 AA;  82221 MW;  107745FD108699FB CRC64;
     MSTGSSPFVD HKSNNSTISI NNNSSILNES SISKAYVSKL EFQLDTIKTE NRILQQEKDQ
     ITSDYRKIID EKNQELENLK LNFKYVYDEK NQLESKLTNQ EQVSTNNINQ LSDEIQTYKR
     ENLKLTKDYN SLLDKFNKLN RKNQQIMHDL NKEIEVNDKL HQELKIKEKT NQELQKASDT
     AINELEQYSK ILDKKNGSDN LLYKNLTTKS NNLQNINHQL QNKIDQLLQN KTSNELLKQQ
     NQSLLHKLQN LENIESKYLQ LEIEKLQLET KYNDLFKALD TAIASSNEYK DNENTDDTIH
     TSKVKSFIEY CNNLQAKNLT LQEKYDSKII QVKELTKELE DHAREIETDF LPTITDLESK
     LKVYADQNTK LERTKSLREK EITFLRNSLK QMEQIHANQQ HKQQEQEKEE NTENKSISQY
     MTNLEKLVDE YKTKIDELEK KNLEYNKSSI ITNEKTPSNK RQRLESNYTF KTQAIELEKE
     NIEISSKLKQ AESTIEQLKF KISELDKVET RKEQYRILQL KNNLISQDQF IKQTTLIALR
     KENEELINKY IKNLPIEEQI PKGVFQRQED DKQRLQAQID HLTKRSTRLR EVFTKKSKDI
     ITVIAKYFGF IIEFLPNPIN PTDLFSRIKL RSRYIPSEED CYLIIDVENR GLKAHGNFQF
     KQICEELAQY WVNENNQFPC LLSAVNLKLY EIYASK